Nicotinic acid controlled releasing tablet and preparation method thereof

A technology of controlled-release tablets and niacin, which is applied in the field of medicine and can solve problems such as toxicity and facial flushing

Inactive Publication Date: 2005-11-23
山东特瑞林医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the half-life of niacin is only 45 minutes, it is necessary to take a large dose of niacin in clinical practice, 3-6g·d -1 , divided into 3 or 4 doses, but facial flushing and hepatotoxicity often occur

Method used

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  • Nicotinic acid controlled releasing tablet and preparation method thereof
  • Nicotinic acid controlled releasing tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: Nicotinic acid controlled-release tablet

[0030] 1. Tablet core composition:

[0031] Raw material name mg / tablet

[0032] Niacin 250

[0033] Lactose 200

[0034] Starch 150

[0035] Hypromellose 10

[0036] Magnesium stearate 0.8

[0037] Talc powder 1

[0038] 2. Membrane controlled release coating composition:

[0039] Ethyl cellulose 42

[0040] Methylcellulose 2

[0041] Glycerin 1.5

[0042] Operation method:

[0043] 1. Grind niacin and fillers according to the above formula, sieve and mix evenly, make soft materials with binders, granulate, granulate after drying, add lubricant and glidant and mix evenly, and press into tablet cores .

[0044] 2. Prepare the controlled-release coating solution according to the above-mentioned film controlled-release coating composition prescription, put the prepared tablet cores in the coating pan, and coat with the coating solution.

[0045] 3. Dry and inspect the package.

[0046] time (h...

Embodiment 2

[0047] Embodiment 2: Nicotinic acid controlled-release tablet

[0048] 1. Tablet core composition:

[0049] Raw material name mg / tablet

[0050] Niacin 250

[0051] Microcrystalline Cellulose 120

[0052] Starch 80

[0053] Polyvinylpyrrolidone 12

[0054] Polyethylene glycol 1.5

[0055] Talc 1.5

[0056] 2. Membrane controlled release coating composition:

[0057] Cellulose acetate 40

[0058] Hypromellose 2.5

[0059] Diethyl phthalate 3

[0060] Preparation method is the same as example 1.

[0061] time (hours)

example 3

[0062] Example 3, Niacin Controlled-release Tablets

[0063] 1. Tablet core composition:

[0064] Raw material name mg / tablet

[0065] Niacin 250

[0066] Polyvinyl alcohol 280

[0067] Calcium sulfate 350

[0068] Starch slurry 15

[0069] Polyethylene glycol 1.5

[0070] Micronized silica gel 2

[0071]2. Membrane controlled release coating composition:

[0072] PVC 38

[0073] Polyvinylpyrrolidone 3

[0074] Dioctyl phthalate 2.5

[0075] Preparation method is the same as example 1

[0076] time (hours)

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Abstract

The invention relates to a nicotinic acid controlled releasing tablet which comprises core constituents and film control release coating constituents, the preparing process consists of mixing prescription amount of nicotinic acid with core constituents, tabletting into cores, then preparing coating liquid from the film control release coating constituents, finally loading the prepared cores into a coating pan, and coating with coating liquids.

Description

(1) Technical field [0001] The invention relates to a niacin controlled-release tablet and a preparation method thereof, belonging to the technical field of medicine. (2) Background technology [0002] Niacin (nicohnic acid) is a drug for the treatment of hyperlipidemia, which can reduce the content of low-density lipoprotein and triglyceride, and increase the content of high-density lipoprotein. Because the half-life of niacin is only 45 minutes, it is necessary to take a large dose of niacin in clinical practice, 3-6g·d -1 , divided into 3 or 4 times, but facial flushing and liver toxicity often occur. (3) Contents of the invention [0003] Aiming at the deficiencies of the prior art, the invention provides a nicotinic acid controlled-release tablet and a preparation method thereof. [0004] The present invention is a nicotinic acid controlled-release tablet, which is characterized in that it comprises the following components, all in weight percent: [0005] 1) Table...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/455
Inventor 肖广常张颖
Owner 山东特瑞林医药科技发展有限公司
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