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Method and equipment of integrated reaction and separation for preparing chitosan oligosaccharide

A separation method and technology of chitosan oligosaccharides, which are applied in the field of integrated reaction separation methods and devices for the preparation of chitosan oligosaccharides, can solve problems such as difficulty in obtaining active oligosaccharides, difficulty in obtaining specific enzymes, consumption of chemical oxidants, etc., and achieve economical Good performance, easy integration, high extraction purity and high efficiency

Inactive Publication Date: 2005-10-26
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Wherein, method (1) reaction is bad control, what mainly obtain is monosaccharide, disaccharide, is difficult to obtain required active oligosaccharide; Method (2) needs to consume chemical oxidant, can pollute environment directly or indirectly; Method (3) ) has high technical requirements, specific enzymes are difficult to obtain, and the reaction cycle is long

Method used

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  • Method and equipment of integrated reaction and separation for preparing chitosan oligosaccharide
  • Method and equipment of integrated reaction and separation for preparing chitosan oligosaccharide
  • Method and equipment of integrated reaction and separation for preparing chitosan oligosaccharide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] In the electrochemical degradation reaction part shown in Fig. 1, Fig. 2 and Fig. 3, the output voltage of the DC power supply 2 is 0-12V, and the current is 0-20A.

[0025] Adopt electrochemical reactor 1 to carry out chitosan degradation reaction, its structural type is as follows Figure 4As shown, the box-type housing 15 in the figure is made of non-metallic materials, and the electrode plate 16 is composed of 4 artificial graphite plates, with a width of 380mm, a height of 180mm, and an average thickness of 18mm. They are arranged in parallel to form a bipolar three-section series connection. Advanced diaphragmless electrochemical reactor, the average distance between electrodes is 20mm, and the single electrode area is 6.8dm 2 , Effective reaction solution volume 5L.

[0026] The concentration of chitosan input is 10g / L, the concentration of NaCl is 20g / L, the pH value of the solution is 1~3, the reaction temperature is 40~50℃, and the current density is 2~3A / dm ...

Embodiment 2

[0030] The degradation reaction apparatus used is the same as Example 1.

[0031] The concentration of chitosan input is 20g / L, the concentration of NaCl is 20g / L, the pH value of the solution is 1-3, the reaction temperature is 50-60°C, and the current density is 2-3A / dm 2 .

[0032] Reaction control method is the same as example 1, still taking 90% of viscosity drop as control target.

[0033] Finally, the reaction time was 130min, and the reaction completion liquid was measured, and the generation rate of chitosan oligosaccharide was 84.5%, and the reaction completion liquid was light yellow-green.

Embodiment 3

[0035] The degradation reaction apparatus used is the same as Example 1.

[0036] The concentration of chitosan input is 20g / L, the concentration of NaCl is 20g / L, the pH value of the solution is 1~3, the reaction temperature is 60~70℃, and the current density is 2~3A / dm 2 .

[0037] The reaction control method is the same as Example 1. Still take the viscosity drop of 90% as the control target.

[0038] Finally, the reaction time was 120min, and the reaction completion liquid was measured, and the generation rate of chitosan oligosaccharide was 81.7%, and the reaction completion liquid was light brown. It shows that the side reaction on the surface of the anode increases, and the generation rate of chitosan oligosaccharides decreases.

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Abstract

The present invention discloses an integrated reaction separation method for preparing chitosan oligosaccharide and its equipment. After the chitosan is degraded by electrochemical reaction, said invention adopts analog moving bed to implement integrated separation and extraction of chitosan oligosaccharide. Besides, said invention also provides the electrochemical degradation reaction condition and concrete steps of integrated separation and extraction of said analog moving bed.

Description

technical field [0001] The invention relates to carbohydrates, in particular to an integrated reaction separation method and device for preparation of chitosan oligosaccharides, which adopts an electrochemical reaction degradation chitosan method, a simulated moving bed separation extraction method and an integrated device technology for integrated reaction separation. Background technique [0002] Oligochitosan refers to an oligosaccharide composed of 2 to 10 glucosamine connected by β-1,4-glucosidic bonds, which is obtained by degrading high molecular weight chitosan. Oligochitosan has water solubility and various excellent physiological functions, and has a wide range of application fields and development value, so it has attracted much attention, as described in Chinese patents CN1126756C, CN1177856C and CN1544479A. In the prior art, there are mainly three types of preparation methods: [0003] (1) acid hydrolysis; [0004] (2) chemical oxidation degradation method; ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00
Inventor 杨健王奕
Owner ZHEJIANG UNIV
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