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Novel therapeutic use of polypodium extracts

A technology of water keel and extract, which is applied to medical preparations containing active ingredients, medical raw materials derived from ferns/filamentous plants, drug combinations, etc., which can solve problems such as fever, discomfort, and reduction of patients' sexual desire

Inactive Publication Date: 2005-10-05
ESP FARMS CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The administration of the above drugs can cause side effects: interferon can cause fever, malaise and mialgia; corticosteroids administered in the lesion can produce gangrene; oral administration of tamoxifen can reduce the patient's sexual desire and eyaculate

Method used

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  • Novel therapeutic use of polypodium extracts
  • Novel therapeutic use of polypodium extracts
  • Novel therapeutic use of polypodium extracts

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Example 1. Effect of Water Keelia Extract on Extracellular Matrix

[0063] Water keel extract

[0064] It was firstly extracted for 48 hours, then filtered with a membrane, and then the solvent was removed under low pressure, then dissolved in the physiological serum again, and finally freeze-dried to obtain the extract of the genus Thuisi. Extracts can be dissolved in PBS and used after regeneration.

[0065] cell culture

[0066] Obtain fibroblasts from surgical material. The skin fragments were placed in RPMI1640 medium at 4°C and 2% (double dose) penicillin and streptomycin solution, and pre-incubated for 2 hours. After removal of adipose tissue, small pieces of skin were fixed in microwells moistened with fetal calf serum (FCS). at 5% CO 2 Skin cells were cultured in RPMI1964 medium containing 10% FCS and 1% penicillin / streptomycin solution under gaseous environment. This medium is updated twice a week. Fibroblasts were first cultured in Tripsin and EDTA...

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PUM

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Abstract

New therapeutic use of Polypodium extract. A new use of Polypodacea genus extracts is described for the treatment of fibrotic pathologies, such as, scleroderma, pulmonary fibrosis, atherosclerosis, bone marrow fibrosis, liver fibrosis, pancreatic fibrosis, kidney fibrosis, cardiac fibrosis, Dupuytrem's disease and, specially, Peyronie's disease.

Description

field of invention [0001] The invention discloses a novel therapeutic agent of the extract of the genus Trichum, in particular for the treatment of fibrosis. Background of the invention [0002] Tissue fibrosis is a chronic disorder characterized by overexpression of extracellular matrix (mainly collagen and fibronectin) and proliferation of fibroblasts. [0003] Recently, it was discovered that transforming growth factor beta (TGF-β) is involved in all fibrotic disorders and that TGF-β independently induces the expression of the disordered ECM proteins. For example, scleroderma, hepatic fibrosis, myelofibrosis, cardiac fibrosis, pulmonary fibrosis, atherosclerosis, pancreatic fibrosis, renal fibrosis, Dupuytren's disease, or Peyronie's disease may be cited for fibrotic disease. [0004] The history, etiology, and epidemiology of Peyronie's disease are unknown. Genetic factors, traumatic factors, high arterial pressure, and / or congenital factors can all serve as pathogeni...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/00A61K36/11A61P7/00A61P9/00A61P9/10A61P9/12A61P11/00A61P13/12A61P15/00A61P15/10A61P17/00A61P17/02A61P21/00A61P35/00A61P43/00
CPCA61K36/11A61P7/00A61P9/00A61P9/10A61P9/12A61P11/00A61P13/12A61P15/00A61P15/10A61P17/00A61P17/02A61P21/00A61P35/00A61P43/00A61K36/12
Inventor 埃利塞奥·金塔尼丽亚·阿尔马格罗
Owner ESP FARMS CENT
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