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Compound ambroxol and cephalosporins preparation and application thereof

A technology of cephalosporin and ambroxol, applied in pill delivery, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problem of inconvenient taking and synergistic effect

Inactive Publication Date: 2005-09-07
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] But in terms of treatment, either antibacterial or phlegm-reducing, even if it is used in combination, multiple drugs need to be taken at the same time, which is inconvenient to take and cannot better exert the synergistic effect of the two

Method used

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  • Compound ambroxol and cephalosporins preparation and application thereof
  • Compound ambroxol and cephalosporins preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1: Preparation of Ambroxol Hydrochloride+Cefadroxil Common Tablets

[0045] Prescription: 1000 tablets

[0046] Ambroxol Hydrochloride 15g

[0047] Cefadroxil 125g

[0048] Lactose 40g

[0049] Microcrystalline Cellulose 94g

[0050] Hypromellose 10g

[0051] Crospovidone 12g

[0052] Micronized silica gel 2.5g

[0053] Magnesium Stearate 1.5g

[0054] Preparation method: pass the medicine and auxiliary materials through 80 mesh sieve respectively, weigh the prescription amount of ambroxol hydrochloride, cefadroxil, lactose, microcrystalline cellulose, hypromellose, crospovidone, micropowder silica gel, stearin Magnesium acid is mixed evenly, and the powder is directly compressed into tablets.

Embodiment 2

[0055] Embodiment 2: prepare ambroxol hydrochloride+cephalexin film-coated tablet

[0056] Prescription: 1000 tablets 1000 tablets

[0057] Cephalexin 125g Ambroxol Hydrochloride 15g

[0058] Starch 40g Starch 50g

[0059] 10% starch slurry 6g dextrin 30g

[0060] 5% povidone 75% ethanol solution 4g

[0061] Microcrystalline Cellulose 34g

[0062] Crospovidone 14g

[0063] Magnesium Stearate 2g

[0064] Preparation method: granulate cephalexin and ambroxol hydrochloride with appropriate amount of auxiliary materials respectively. Weigh the prescription amount of cephalexin and starch, mix them evenly, make soft material with 10% starch slurry, pass through 18 mesh sieve to granulate, dry at 60°C, and granulate with 16 mesh sieve. Take by weighing recipe quantity ambroxol hydrochloride, star...

Embodiment 3

[0065] Embodiment 3: preparation cephradine+ambroxol hydrochloride capsule

[0066] Prescription: 1000 capsules

[0067] Ambroxol hydrochloride (through 80 mesh sieve) 30g

[0068] Cephradine (through 80 mesh sieve) 250g

[0069] Microcrystalline Cellulose 96g

[0070] Micronized silica gel 4g

[0071] capsule shell

[0072] Preparation method: pass the medicine and auxiliary materials through 80-mesh sieve respectively, weigh the prescribed amount of ambroxol hydrochloride, cephradine, microcrystalline cellulose, and micropowder silica gel, mix evenly, and directly fill the powder into the capsule shell to obtain.

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PUM

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Abstract

The invention relates to a compound ambroxol and cephalosporins preparation and application, wherein unit dosage of the compound medicinal preparation comprises 7.5mg-90mg of Ambroxol, 12.5-500mg of cephalosporins medicament and right amount of medicinal adjuvant.

Description

Technical field: [0001] The present invention relates to a kind of compound medicine preparation, especially relates to the medicine preparation that contains 7.5mg~90mg of ambroxol, 12.5~500mg of cephalosporins and proper amount of pharmaceutically acceptable auxiliary materials in the preparation of unit dosage. Background technique: [0002] Cephalosporin antibiotics are broad-spectrum antibiotics, which have the advantages of strong antibacterial activity, broad antibacterial spectrum, high blood concentration, wide distribution in the body, and strong tissue penetration. They can effectively decompose the β-lactamase produced by pathogenic bacteria, Therefore, it shows strong antibacterial activity against many Gram-positive bacteria, Gram-negative bacteria and anaerobic bacteria. Good curative effect, especially enhanced antibacterial effect on penicillin-resistant strains, especially suitable for treating drug-resistant bacterial infections with multiple diseases and ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K9/48A61K31/545A61K45/06A61P11/00A61P27/16
Inventor 鄂滟蔡金巧
Owner FUKANGREN BIO PHARMA
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