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Granular folacin production method and product

A production method and a granular technology are applied to the molding processing method and product field of folic acid after the synthesis process, so as to achieve the effects of not harsh operating conditions, promoting clean production and simplifying the production process

Inactive Publication Date: 2005-07-06
CHANGZHOU NIUTANG CHEM PLANT CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the popularization of dosage forms such as capsules, downstream enterprises would prefer folic acid suppliers to provide granular folic acid products with a particle size within a certain range, which poses a new technical problem for folic acid suppliers, requiring The folic acid after synthesis and purification is further molded and processed, and it can't just be dried.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Sodium acetate is used as a catalyst to directly react "triaminohydroxypyrimidine sulfate", "sodium p-aminoglutamate", "trichloroacetone" and "pyrosulfurous acid" at 36 ° C ~ 40 ° C to obtain primary crude folic acid Then wash with hydrochloric acid and filter to obtain secondary crude folic acid; then wash with hydrochloric acid, neutralize to neutral with lye, and filter to obtain a wet product of fine folic acid with higher purity.

[0019] Add the prepared refined folic acid wet product into deionized water, stir and mix to make a paste-like solid-liquid mixture with a solid content of 28% to 45%; then put the paste-like solid-liquid mixture into the screw pump inlet, start the screw pump, Control the absolute pressure of the screw pump discharge within the range of 1-2MPa; use the pressure-type spray granulation dryer, when the inlet air temperature is 210°C-320°C, the outlet air temperature is 90°C-150°C, and the absolute pressure does not exceed 2MPa Under certai...

Embodiment 2

[0021] Use the powdered folic acid finished product on the market as raw material, add deionized water, stir and mix to make a paste-like solid-liquid mixture with a solid content of 28% to 45%; then put the paste-like solid-liquid mixture into the inlet of the screw pump and start Screw pump, control the absolute pressure of the screw pump discharge within the range of 1 to 2 MPa; use the pressure spray granulation dryer, when the air inlet temperature is 210°C to 320°C, the outlet air temperature is 90°C to 150°C, the absolute pressure Under the condition of no more than 2MPa, the pasty solid-liquid mixture is squeezed out of the screw pump, sprayed granulated, dried and formed simultaneously; sieved, and the product with a particle size range of 20 mesh to 120 mesh is collected to obtain granular folic acid. The product is orange-yellow, with uniform particle size and good fluidity.

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PUM

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Abstract

The invention relates to the forming process of folic acid after the synthesizing procedure, which consists of charging deionized water, preparing paste with 28-45% of solid content, loading into screw pump, using a pressure type spray and granulation drier to squeeze the paste out of the screw pump at the air intake temperature of 210-320 deg. C and air-out temperature of 90-150 deg. C, simultaneously carrying out atomizing and granulating, drying and compacting, and finally obtaining 20-120 mesh of granular folic acid product through sieving.

Description

technical field [0001] The invention relates to a production method of folic acid, in particular to a molding processing method and products of folic acid after the synthesis process. Background technique [0002] Folic acid (C 19 h 19 N 7 o 6 ), also known as vitamin M, is an anti-anemia drug and is also used as a food additive. There are many chemical synthesis methods of folic acid. The earlier method of use is to react "p-aminobenzoyl-L-glutamic acid diethyl ester" with "2-hydroxymalonaldehyde" to separate "p- (2,3-dihydroxy-2-ene-propylene amino)-benzoic acid diethyl ester", and make this intermediate react with "triaminopyrimidinone" to prepare folic acid (JACS, 70(1948) , 25); Later, "2-substituted malondialdehyde" was used to react with "p-aminobenzoyl-L-glutamic acid" to obtain the corresponding diimine, and then in the presence of sulfite, at pH Folic acid (CN1040209C) is obtained by reacting with "triaminopyrimidinone" under the conditions of 3 to 8; the met...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/519C07D475/04
Inventor 王方大徐建平王立成
Owner CHANGZHOU NIUTANG CHEM PLANT CO LTD
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