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Externally used liquid preparation containing fibrauretine and its application on genital tract, oral cavity and upper respiratory tract

A liquid preparation, the technology of patulin, applied in the fields of foam aerosol, ointment, spray, patina lotion, and mouthwash, can solve the problems of many side effects, easy to be polluted, poor patient compliance, etc., Achieving good therapeutic effect, good patient compliance, and less toxic and side effects

Inactive Publication Date: 2005-06-22
赵远 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Existing palmatine preparations include injections, tablets, suppositories, etc. Although they are effective in treating gynecological and oral infections, the injections have harsh production process conditions, inconvenient use, low local drug concentration in the lesion, long treatment period, poor patient compliance, and many side effects. Disadvantages: Oral tablets have disadvantages such as large dose, gastrointestinal irritation, easy to cause intestinal flora imbalance, slow onset of action, low bioavailability, long treatment period, and low local drug concentration in lesions; although suppositories directly act on the disease-causing site, However, it is inconvenient to use, easy to be polluted, and a large amount of matrix affects the degree of drug action and release. When the ambient temperature is too high, it can absorb moisture and stick, and it is often easy to lose water when it is dry and becomes brittle, broken, deformed, discolored, sticky, melting, affect the use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The embodiment of embodiment 1 palmatine liquid washing (wiping) agent

[0023] ①Prescription (dosage per 100ml)

[0024] Palmatine 0.1g (0.1%)

[0025] Sterile water 99.9g (99.9%)

[0026] ②Preparation method: Dissolve the prescribed amount of palmatine in water and mix well.

Embodiment 2

[0027] The embodiment of embodiment 2 palmatine liquid washing (wiping) agent

[0028] ①Prescription (dosage per 100ml)

[0029] Palmatine 2g (2.0%)

[0030] Sterile water 98g (98.0%)

[0031] ②Preparation method: Dissolve the prescribed amount of palmatine in water and mix well.

Embodiment 3

[0032] The embodiment of embodiment 3 palmatine liquid washing (wiping) agent

[0033] ①Prescription (dosage per 100ml)

[0034] Palmatine 49.99g (49.99%)

[0035] Sterile water 50.01g (50.01%)

[0036] ②Preparation method: Dissolve the prescribed amount of palmatine in water and mix well.

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PUM

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Abstract

Disclosed is externally used fibrauretine liquid for gynaecology and oral cavity, wherein the preparation essentially comprises fibrauretine as active constituent, and balancing adjuvant and water for preparing the externally used liquid preparation, the fibrauretine is alkaloid extracted from natural plant of fibraurea stem, calculated by dried product, it comprises Palmatine Hydrochloride C21H21O.HCl 20-98%. The dosage type includes externally used liquid lotion or liniment, foam aerosol, ointment, gargle or spray.

Description

technical field [0001] The invention relates to an external liquid preparation of palmetine for gynecology and stomatology, in particular to a palmetine washing (rubbing) agent, foam aerosol, ointment, mouthwash, and spray. Background technique [0002] Candida albicans belongs to the genus Candida, also known as Candida albicans. Microscopic examination after culture shows oval blastocytic cells and pseudohyphae. It is an opportunistic pathogenic bacteria that usually exists in the oral cavity and upper respiratory tract of normal people. And on the genital vaginal mucosa, when the immune function of the body is reduced or the mutual restriction between the normal resident microorganisms is out of balance, it is easy to cause candidiasis. [0003] In the past 20 years, Candida albicans infection has increased more than 20 times, and it has become one of the main causes of death of hospital infection. Especially in the past 10 years, the proportion of Candida albicans in pa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K9/08A61K9/10A61K9/12A61K31/4375A61P1/02A61P11/00A61P15/00A61P31/04
Inventor 赵远董跃伟
Owner 赵远
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