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Injected gel type bone repairing biological active material and its preparing method

A bioactive and bone repair technology, applied in the field of medical biology, can solve the problems of complicated operation and high use cost, and achieve the effects of good biocompatibility, simple use and pain relief.

Inactive Publication Date: 2005-03-02
徐放
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing bone repair materials need to be surgically implanted into the traumatic site, which is not only complicated to operate, but also expensive to use, and the patient suffers a lot, and is not suitable for closed fractures and other orthopedic cases that do not require surgery.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1) Dissolve 1.5g of sodium alginate in 100ml of water to form an aqueous solution with a concentration of 1.5%, add 10mg of bone morphogenetic protein to 100ml of the solution, add 2g of mannitol, mix well, and lyophilize. This is group A;

[0032] 2) Take 367mg of calcium carbonate and 436mg of gluconolactone, add 4197mg of mannitol, and mix well;

[0033] 3) Add 800 ul of polyvinylpyrrolidone ethanol solution with a concentration of 8% to the mixture obtained in 2), mix evenly after wetting, prepare an ointment, squeeze through a 20-mesh sieve into granules, dry at 80°C, and pass through a 60-mesh sieve whole grain. This is component B;

[0034] 4) with 60 Co irradiates components A and B for sterilization, and the irradiation dose is 6KGy;

[0035] 5) Divide components A and B into products.

Embodiment 2

[0037] 1) Dissolve 1.5g of sodium alginate in 100ml of water to prepare an aqueous solution with a concentration of 1.5%, add 50mg of bone morphogenetic protein to 100ml of this solution, add 2g of mannitol, mix well, and lyophilize. This is component A ;

[0038] 2) Add 440mg of calcium sulfate, 436mg of gluconolactone, 4124mg of mannitol, and mix well.

[0039] 3) Add 800 ul of 8% polyvinylpyrrolidone ethanol solution to the mixture obtained in 2), mix evenly after wetting, prepare an ointment, squeeze through a 20-mesh sieve into granules, dry at 80°C, pass through a 60-mesh sieve for granulation . This is the B component.

[0040] 4) with 60 Co irradiates components A and B for sterilization, and the irradiation dose is 6KGy.

[0041] 5) Divide components A and B into products.

Embodiment 3

[0043] 1) Dissolve 1.5g of sodium alginate in 100ml of water to form an aqueous solution with a concentration of 1.5%, add 100mg of bone morphogenetic protein to 100ml of this solution, add 1.5g of mannitol, mix well, and lyophilize. This is group A Minute;

[0044] 2) Add 220.2mg of calcium carbonate, 261.6mg of gluconolactone, 2518.2mg of mannitol, and mix well;

[0045] 3) Add 480 ul of 8% polyvinylpyrrolidone ethanol solution to the mixture obtained in 2), mix evenly after wetting, prepare an ointment, squeeze through a 20-mesh sieve into granules, dry at 80°C, pass through a 60-mesh sieve for granulation . This is component B;

[0046] 4) with 60 Co irradiates components A and B for sterilization, and the irradiation dose is 6KGy;

[0047] 5) Divide components A and B into products.

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PUM

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Abstract

Of the bioactive gel injection material for bone repairing, each dose consists of component A in 1 ml and component B in 45-55 mg. The component A contains sodium alginate 10-40 mg, bone morphogenetic protein 0.1-1 mg and mannitol 10-20 mg in each ml of bacteria-free physiological saline. Of the component B, each mg contains water insoluble calcium compound 0.05-0.15 mg, gluconolactone 0.05-0.3 mg and polyvinyl pyrrolidone 0.004-0.016 mg except mannitol. The injection material for bone repairing has excellent biocompatibility and simple and safe use, and may be injected to required bone treating position. Animal experiment shows that it has similar bone forming activity to operation implanted solid bone repairing material containing bone morphogenetic protein.

Description

technical field [0001] The invention relates to an injected gel-type bone repair bioactive material and a preparation method thereof, belonging to the field of medical biotechnology. Background technique [0002] (1) Injectable gel drug delivery system [0003] It is a better drug delivery system to compound the drug with a degradable material, and then deliver it to a specific part of the body through injection, make it solidify to form a gel, release the drug and play a therapeutic role. This drug delivery system is easy to use, can prolong the action time of the drug in the body, reduce the dosage of the drug to avoid possible side effects, and implant the drug into the body without surgery, reducing the pain of the patient. [0004] (2) Bioactive materials for bone repair [0005] Bone morphogenetic proteins are a class of cell growth factors that can induce undifferentiated mesenchymal stem cells to differentiate into osteoblasts and proliferate to form cartilage and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K38/18A61L27/42A61L27/44A61L27/50A61L27/52A61L27/54A61P19/08
CPCA61L27/52A61L27/446A61L2300/252A61L27/54A61L27/50A61K38/1875A61L2400/06A61L2430/02A61P19/00A61P19/08
Inventor 徐放潘绵立
Owner 徐放
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