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Skin targeting medicinal composition and its preparation and use

A composition and targeting technology, which can be used in drug combinations, medical preparations containing active ingredients, skin diseases, etc., can solve problems such as limited application, toxic and side effects, achieve good skin targeting, reduce toxic and side effects, Visible skin-targeting effect

Inactive Publication Date: 2005-02-23
HUAZHONG UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Podophyllotoxin, imiquimod and other topical skin active drugs have obvious irritation to the skin, such as local itching, erythema, burning sensation, irritation, tenderness, ulceration, erosion and pain. When the drug is absorbed through the skin and enters the blood, it will Severe systemic toxic and side effects limit its clinical application

Method used

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  • Skin targeting medicinal composition and its preparation and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Pharmaceutical composition of podophyllotoxin microemulsion with skin targeting

[0037]3 g of isopropyl palmitate, 40 g of polyoxyethylene (40) hydrogenated castor oil, and 20 g of propylene glycol were mixed to form a mixed solution, and 0.5 g of podophyllotoxin and 2 g of camphor were dissolved in the mixed solution to obtain an oil phase. Slowly add distilled water into the oil phase under the condition of stirring, so that the total amount reaches 100 g, and obtain a transparent microemulsion after stirring evenly, which is the pharmaceutical composition with skin targeting. The effective particle size was measured at 25°C with a laser particle size analyzer (Nano ZS90, Malvern, UK), and the effective particle size was 70.81 nm.

Embodiment 2

[0039] Pharmaceutical composition of podophyllotoxin microemulsion gel with skin targeting

[0040] After mixing 3 g of isopropyl myristate, 30 g of Tween 80, and 30 g of propylene glycol to form a mixed solution, 0.5 g of podophyllotoxin and 2 g of menthol were dissolved in the mixed solution to obtain an oil phase. Take 0.375g of Carbomer 940 and mix it with water, add 0.5g of triethanolamine after swelling, mix it with the oil phase, stir until it is completely uniform, and obtain a drug combination of podophyllotoxin microemulsion gel with skin targeting things. Use a laser particle size analyzer to measure the particle size distribution of the particles in the dilution of 1ml of water and 0.05mg of microemulsion gel at 25°C, and the largest particle is less than 150nm.

Embodiment 3

[0042] Pharmaceutical composition of podophyllotoxin microemulsion with skin targeting

[0043] Mix 5g medium-chain triglycerides (Miglyol 812), 30g Tween, 5g Poloxamer 188, 30g propylene glycol, and 15g ethanol to form a mixed solution, add 0.5g podophyllotoxin and 3g camphor, and stir to dissolve to obtain oil Mutually. Slowly add distilled water into the oil phase under the condition of stirring, so that the total amount reaches 100 g, and after stirring evenly, a transparent and uniform microemulsion is obtained, which is the pharmaceutical composition with skin targeting. The particle size of the microemulsion measured by laser particle size analyzer is 83.08nm.

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Abstract

A composite medicine with skin target for treating pointed condyloma, viral or fungal infection of skin, and eczema is prepared from oil, surfactant, surfactant assistant, osmotic promoter, active medicine and water through proportional mixing, and adding gel matrix.

Description

field of invention [0001] The invention relates to a microemulsion with skin targeting, a microemulsion gel pharmaceutical composition, a preparation method and application thereof. Background of the invention [0002] Microemulsion is a system composed of oil, surfactant, co-surfactant and hydrophilic phase. It has the characteristics of transparent appearance, thermodynamic stability, isotropy, and the average particle size of dispersed phase droplets is less than 150nm. As a new type of drug delivery system, microemulsion has the advantages of good stability, strong solubility, low viscosity, simple preparation, and easy industrialization. [0003] Podophyllotoxin, imiquimod and other topical skin active drugs have obvious irritation to the skin, such as local itching, erythema, burning sensation, irritation, tenderness, ulceration, erosion and pain. When the drug is absorbed through the skin and enters the blood, it will Severe systemic toxic and side effects are produc...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/365A61K31/4745A61K47/44A61M37/00A61P17/00A61P17/12A61P31/10
Inventor 陈华兵杨祥良徐辉碧杨亚江刘卫周小顺
Owner HUAZHONG UNIV OF SCI & TECH
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