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Implantable pouch seeded with insulin-producing cells to treat diabetes

A diabetes, cell technology, applied in gene therapy, medical raw materials derived from mammals, metabolic diseases, etc.

Inactive Publication Date: 2005-01-26
LIFESCAN INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A limitation of this method is that the transplanted Sertoli and islet cells are not physically confined to the transplantation site

Method used

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  • Implantable pouch seeded with insulin-producing cells to treat diabetes
  • Implantable pouch seeded with insulin-producing cells to treat diabetes
  • Implantable pouch seeded with insulin-producing cells to treat diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1: Preparation of an implantable capsule

[0050] Polymer solutions are prepared to be lyophilized in capsules. The polymer used to generate the foam component was a copolymer of 35% PCL and 65% PGA (35 / 65 PCL / PGA) produced by Birmingham Polymers Inc. (Birmingham, AL), measured in HFIP at 30°C The polymer had an I.V. of 1.79 dL / g. 1,4-dioxane / (35 / 65 PCL / PGA) was weighed in a weight ratio of 95 / 5. The polymer and the solvent were placed in a flask, placed in a water bath at 70° C. and stirred for 5 hours in sequence. The solution was filtered with an extraction cannula (ultra-large pore size, model ASTM170-220 (EC)) and stored in a flask.

[0051] A mesh made of a reinforced mesh material knitting (code VKM-M) formed from a 90 / 10 copolymer of polyglycolic acid / polylactic acid (PGA / PLA) was ironed using a die-casting die at 80° C. for 2 minutes. After preparing the mesh, 0.4 mm spacers were placed on each end of the 15.3 x 15.3 cm aluminum mold and the two mes...

Embodiment 2

[0053] Example 2: Preparation of an implantable capsule

[0054] A biodegradable capsule was prepared as described in Example 1, except that Textile Vicryl (code VWM-M) used a reinforcement mesh formed from a 90 / 10 copolymer of polyglycolic acid / polylactic acid (PGA / PLA) shape material.

Embodiment 3

[0055] Example 3: Preparation of an implantable capsule

[0056] A biodegradable bladder was prepared as described in Example 1, except that a woven reinforced mesh material was used, which was formed from 100% PDS.

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PUM

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Abstract

An implantable pouch and methods for implanting cells or cellular matter in mammals, comprising reinforced porous foam and a lumen. The lumen contains an insert that may or may not be removed prior to transplantation. The lumen may be loaded with at least one cell type expressing at least one transcription factor characteristic of a mammalian pancreatic beta cell.

Description

technical field [0001] The present invention relates to implantable capsules seeded with insulin secreting cells for the treatment of diabetes. In particular, the present invention provides an implantable porous capsule containing an opening for loading insulin secreting cells for treating diabetes, which opening can then be closed, if desired, sealed. Background technique [0002] Pancreatic tissue consists of three parts: exocrine, endocrine, and ducts. The endocrine pancreas includes islet cells responsible for the secretion of four specialized hormones. Such islets are composed of four distinct cell types: alpha, beta, delta, and polypeptide cells, which produce glucagon, insulin, somatostatin, and pancreatic polypeptide, respectively. According to the prior art involving the identification of endocrine cells, several key transcription factors important in β-cell development have been identified, including Pdx1, Ngn3, Hlxb9, Nkx6, Isl1, Pax6, Neurod, Hnfla, Hnf6 and oth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K9/19A61K35/12A61L27/18A61L27/38A61L27/56A61P3/10
CPCA61L27/18A61L27/38A61L27/56A61L27/3804A61P3/10A61P5/48C08L67/04
Inventor A·列扎尼亚M·齐默曼R·M·加布里尔
Owner LIFESCAN INC
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