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Dripping pills of betahistine hydrochloride and its preparation method

A technology of betahistine and statin drop pills, which is applied in the field of betahistine hydrochloride drop pills and its preparation, can solve the problem of affecting the therapeutic effect of betahistine hydrochloride, low dissolution rate and dissolution rate, and disintegration of sugar-coated tablets Long time and other problems, to achieve the effect of convenient carrying and taking, improved dissolution rate and dissolution rate, and small pill volume

Inactive Publication Date: 2005-01-26
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Betahistine hydrochloride has a slightly bitter taste, is easy to deliquescence, and is easily soluble in water, but its sugar-coated tablets have a long disintegration time, low dissolution rate and dissolution rate, poor absorption, low bioavailability, and a large proportion of excipients. Children, the elderly People, bedridden patients and patients with dysphagia are inconvenient to take and have poor compliance, which affects the therapeutic effect of betahistine hydrochloride

Method used

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  • Dripping pills of betahistine hydrochloride and its preparation method

Examples

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Comparison scheme
Effect test

example 1

[0052] prescription:

[0053] Betahistine Hydrochloride 4g

[0054] Macrogol 6000 16g

[0055] Makes 1000 capsules

[0056] Preparation method: Take the fine powder of betahistine hydrochloride that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone as a coolant, make pellets by drop method, and dry. Instantly.

example 2

[0058] prescription:

[0059] Betahistine Hydrochloride 4g

[0060] Macrogol 4000 16g

[0061] Makes 1000 capsules

[0062] Preparation method: Take betahistine hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir well, use simethicone as a coolant, make pellets by drop method, dry, Instantly.

example 3

[0064] prescription:

[0065] Betahistine Hydrochloride 4g

[0066] Macrogol 6000 10g

[0067]Macrogol 4000 6g

[0068] Makes 1000 capsules

[0069] Preparation method: Take the fine powder of betahistine hydrochloride that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten mixed matrix of polyethylene glycol 4000 and polyethylene glycol 6000, stir well, use simethicone as the coolant, Drop system into legal pills, dry, and get it.

[0070] 4. Example 4

[0071] prescription:

[0072] Betahistine Hydrochloride 4g

[0073] Glyceryl monostearate 16g

[0074] Makes 1000 capsules

[0075] Preparation method: Take betahistine hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten glyceryl monostearate matrix, mix well, use ice water as a coolant, make pellets by dropping, dry, and have to.

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Abstract

The invention discloses a betahistine hydrochloride drop pill prepared through ultramicro disintegration and drop pills manufacturing technique, which has the advantages of improving collapse and dissolving speed, dissolving out speed and degree, quick effect, increased medicament stability, reduced adjuvant consumption, lowered production costs, and easiness in carrying and use. It has good compliance, thus is especially suitable for children, the elderly, bedridden patients and dysphagia patients.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to betahistine hydrochloride dropping pills and a preparation method thereof. Background technique [0002] Betahistine hydrochloride is a diamine oxidase inhibitor, which has a more obvious expansion effect on the cerebrovascular and cardiovascular system, especially on the vertebral artery system, significantly increases the blood flow of the heart, brain and peripheral circulation, improves blood circulation, and reduces Systemic blood pressure, in addition, it can increase the blood flow of the cochlea and the front floor, thereby eliminating inner ear vertigo, tinnitus and ear closure, and can also increase capillary permeability, promote the absorption of extracellular fluid, and eliminate lymphatic edema; it can resist the effects of catecholamines Vasoconstriction and lower arterial pressure, and inhibition of plasma coagulation and ADP-induced...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4402A61P9/10A61P9/12
Inventor 钱进许军彭红李平朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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