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Medicine for treating arthrolithiasis and preparing method thereof

A drug and gout technology, applied in the field of medicine, can solve the problems of large toxic and side effects, decreased sperm, not taking more than one dose, and taking it for a long time, and achieve the effect of low toxic and side effects of the drug and reasonable prescription.

Inactive Publication Date: 2004-09-22
TIANJIN TASLY MORDEN TCM RESOURCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these western medicines can quickly relieve pain, stop the acute attack of gout, relieve the deposition of urate in the body, and prevent the formation of gouty arthritis and gouty kidney stones, these medicines have different degrees of damage to the gastrointestinal tract. In severe cases, it can cause abnormal liver and kidney function. Taking the medicine for a long time can cause bone marrow suppression, liver cell necrosis, sperm reduction, neurotoxicity and gastrointestinal reactions. This kind of medicine has serious side effects and is not easy to take for a long time
[0007] On September 29th, 1999, the Patent Invention Bulletin of the Chinese Patent Office disclosed a patent application document called "Compound Sanbi Gout Medicinal Wine", application number 98111903, publication number CN1229658; on March 12th, 1997, a kind of The name is "Tangfengling Medicinal Wine and Preparation Technology", application number 96102851.3, and patent application document with publication number CN1144676A. These two medicinal wines are all made of traditional Chinese medicine and have certain curative effects. It is very inappropriate for people with high blood pressure and high blood pressure, and leopard bones are also used in the "Compound Sanbi Gout Medicine Wine", which is in violation of the regulations on the protection of rare animals
On February 13, 2002, a patent application document called "a kind of traditional Chinese medicine preparation" was disclosed, the application number was 01128347, and the announcement number was CN1335175; No. is 99112794, the patent application document of announcement number CN1269231; On January 19, 1994, a patent application document entitled "Suxiao Tongfeng Pill and its preparation method" was disclosed, the application number is 93111076, and the announcement number CN1080868, in These traditional Chinese medicine preparations all use highly toxic Nuxe Chin. Although this type of medicine has a strong analgesic effect, it should not be taken too much or for a long time when taken orally. Excessive poisoning can cause limb tremors, convulsions, difficulty in breathing, and even coma.
In addition, some traditional Chinese medicine preparations for the treatment of gout often use some toxic insect medicines or more toxic herbal medicines such as Asarum and Aconitum, although they have a certain therapeutic effect, they are not suitable for those patients who are weak.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0250] Embodiment 1: the capsule preparation of medicine of the present invention

[0251] Take selected Chinese medicine raw materials with the following weights, screen, wash, dry, and pulverize for later use:

[0252] Qingfengteng 497g Stir-fried Cangzhu 414g Phellodendron 165g,

[0253] Motherwort 248g Polygonum cuspidatum 248g Cotton  248g,

[0254] (1), the ethanol extraction of 12 times and 8 times of 70%-95% ethanol was used to extract twice, and the extraction time was 1.5 hours. The liquid was combined twice, and the ethanol was reclaimed and concentrated to a relative density of 1.30, at 45 Dry at -55°C to obtain dry extract 1;

[0255] (2), decoct the residue of Qingfengteng with 10 times the amount and 8 times the amount of water of six traditional Chinese medicines such as fried atractylodes atractylodes, Cortex Phellodendri, Motherwort, Polygonum cuspidatum, and Mian , for 2 hours each time. Concentrate under pressure to a relative density of 1.30, and dry ...

Embodiment 2

[0257] Embodiment 2: Preparation of pharmaceutical granules of the present invention

[0258] Take selected Chinese medicine raw materials with the following weights, screen, wash, dry, and pulverize for later use:

[0259] Qingfengteng 662g, Stir-fried Atractylodes 331g, Phellodendron 220g,

[0260] Motherwort 331g Polygonum cuspidatum 331g Cotton grass 331g,

[0261] (1), the ethanol extraction of 12 times and 8 times of 70%-95% ethanol was used to extract twice, and the extraction time was 1.5 hours. The liquid was combined twice, and the ethanol was reclaimed and concentrated to a relative density of 1.30, at 45 Dry at -55°C to obtain dry extract 1;

[0262] (2), decoct the residue of Qingfengteng with 10 times the amount and 8 times the amount of water of six traditional Chinese medicines such as fried atractylodes atractylodes, Cortex Phellodendri, Motherwort, Polygonum cuspidatum, and Mian , for 2 hours each time. Concentrate under pressure to a relative density of 1....

Embodiment 3

[0264] Embodiment 3: Preparation of pharmaceutical granules of the present invention

[0265] Take selected Chinese medicine raw materials with the following weights, screen, wash, dry, and pulverize for later use:

[0266] Qingfengteng 993g, Stir-fried Atractylodes 398g, Phellodendron 330g,

[0267] Motherwort 497g Polygonum cuspidatum 497g Cotton  497g,

[0268] (1), the ethanol extraction of 12 times and 8 times of 70%-95% ethanol was used to extract twice, and the extraction time was 1.5 hours. The liquid was combined twice, and the ethanol was reclaimed and concentrated to a relative density of 1.30, at 45 Dry at -55°C to obtain dry extract 1;

[0269] (2), decoct the residue of Qingfengteng with 10 times the amount and 8 times the amount of water of six traditional Chinese medicines such as fried atractylodes atractylodes, Cortex Phellodendri, Motherwort, Polygonum cuspidatum, and Mian , for 2 hours each time. Concentrate under pressure to a relative density of 1.30...

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PUM

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Abstract

An interior-applied Chinese medicine for treating gout and preventing joint deformity, gout complication, uric-acid calculus and tophus is prepared from 6 Chinese-medicinal materials including astractylodes rhizome, phellodendron bark, motherwort, giant knotweed rhizome, etc through proportioning and extracting in alcohol or water. Its advantages are quickly taking its effect, high curative effect and no by-effect.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a medicine for treating gout and a preparation method thereof. Background technique [0002] Gout is a common disease in European and American countries. In the past, it was believed that gout was relatively rare in oriental ethnic groups, but facts have proved that the incidence rate has been on the rise in recent years. Gout is a congenital genetic metabolic defect disease, which is mostly induced by a large intake of high-purine-rich foods the day after tomorrow. The disorder of purine metabolism in the human body can easily lead to the disorder of purine base metabolism, excessive production of uric acid, impairment of renal excretion function, and increased blood uric acid. Urate is more likely to crystallize and deposit in the soft tissues around the joints, causing joint swelling, causing non-specific inflammatory reactions, and severe pain. Deposited sodium urate is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P19/06
Inventor 路志正路洁
Owner TIANJIN TASLY MORDEN TCM RESOURCES
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