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Breviscapine disperisng tablets composition and its preparation

A technology of breviscapine and dispersible tablets, which can be applied in drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas. Rapid dissolution, high bioavailability, and good dispersion state

Inactive Publication Date: 2004-09-22
ZILU PHARMA SUZHOU CITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented product improves its ability to release drugs quickly from solid medications while also being easy to use because they are easily soluble when mixed into liquids like saliva without losing their effectiveness due to poor dispersibility caused by existing formulations such as pills (which may have difficulty taking them).

Problems solved by technology

This patented technical problem addressed in this patents relates to improving the efficiency at treating various medical conditions such as arteriosclerosis due to blood clots accumulation within narrowed vessels called veins. Current methods involve taking medicine slowly through them repeatedly until there's enough time left untreatable without causing complications like blockages.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Breviscapine 20.78g

[0023] Lactose 70.00g

[0024] Microcrystalline Cellulose 40.00g

[0025] Crospovidone 7.50g

[0026] Aspartame 2.50g

[0027] Povidone 6.00g

[0028] Sodium bicarbonate 4.00g

[0029] Appropriate amount of polyethylene glycol

[0030] Magnesium Stearate Appropriate amount

[0031] A total of 1000 pieces were pressed

[0032] The preparation process of embodiment is as follows:

[0033] Raw and auxiliary materials are passed through 80-mesh sieve before weighing. Precisely weighed breviscapine, lactose, microcrystalline cellulose, crospovidone (4.5g), aspartame, povidone, and sodium bicarbonate in the prescribed amount, and added the main drug and each The auxiliary materials are first mixed by hand. Go through 80 mesh sieve twice.

[0034] The mixed material is placed in a suitable container, and an appropriate amount of 15% (g / 100ml) polyethylene glycol 6000 75% ethanol solution is added to make a soft material. 20 mesh extrusion sie...

Embodiment 2

[0037] Breviscapine 25.00g

[0038] Lactose 55.00g

[0039] Microcrystalline Cellulose 50.00g

[0040] Crospovidone 8.30g

[0041] Sodium saccharin 1.80g

[0042] Povidone 7.00g

[0043] Sodium bicarbonate 3.8g

[0044] Appropriate amount of polyethylene glycol

[0045] Magnesium Stearate Appropriate amount

[0046] A total of 1000 pieces were pressed

[0047] The preparation process of embodiment is as follows:

[0048] Raw and auxiliary materials are passed through 80-mesh sieve before weighing. Precisely weighed breviscapine, lactose, microcrystalline cellulose, crospovidone (3.7g), aspartame, povidone, and sodium bicarbonate in the prescribed amount, and added the main drug and each The auxiliary materials are first mixed by hand. Go through 80 mesh sieve twice.

[0049] Put the mixed material into an appropriate container, add an appropriate amount of 10% (g / 100ml) polyethylene glycol 6000 75% ethanol solution, and make a soft material. 20 mesh extrusion sie...

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Abstract

A composite dispersing breviscapine tablet for treating apoplexy, coronary heart disease and angina pectoris is prepared from breviscapine (7-15 wt.%), excipient, disintegrant, diluent, lubricant, antisticking agent, pH regulator and sweetening agent. Its advantages are high disintegrating and dissolving speed in the water at 19-21 deg.C, fast absorption, and high biologic utilization rate.

Description

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Claims

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Application Information

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Owner ZILU PHARMA SUZHOU CITY
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