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Ubenimex drop pill and preparing method thereof

A technology of ubenimex and dropping pills, which is applied in the field of ubenimex dropping pills and its preparation, and can solve problems such as affecting the therapeutic effect of ubenimex, low dissolution rate and dissolution rate, and long disintegration time of capsules , to achieve the effect of convenient carrying and taking, improved dissolution rate and dissolution rate, and small pill volume

Inactive Publication Date: 2004-09-15
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Ubenimex is odorless, bitter in taste, and slightly soluble in water. Its capsule disintegrates for a long time, has low dissolution rate and dissolution rate, poor absorption, low bioavailability, and a large proportion of excipients. Children, the elderly, and bedridden patients It is inconvenient to take and poor compliance for patients with dysphagia, which affects the therapeutic effect of Ubenimex

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0052] prescription:

[0053] Ubenimex 5g

[0054] Macrogol 6000 15g

[0055] Makes 1000 capsules

[0056] Preparation method: Take Ubenimex fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone oil as a coolant, make pellets by drop method, and dry. have to.

example 2

[0058] prescription:

[0059] Ubenimex 5g

[0060] Macrogol 4000 15g

[0061] Makes 1000 capsules

[0062] Preparation method: Take Ubenimex fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir well, use simethicone oil as a coolant, make pellets by drop method, and dry. have to.

example 3

[0064] prescription:

[0065] Ubenimex 5g

[0066] Macrogol 6000 5g

[0067] Macrogol 4000 10g

[0068] Makes 1000 capsules

[0069] Preparation method: Take Ubenimex fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten mixed matrix of polyethylene glycol 4000 and polyethylene glycol 6000, stir well, use simethicone as coolant, drop The preparation method is to make pills, dry them, and obtain them.

[0070] 4. Example 4

[0071] prescription:

[0072] Ubenimex 5g

[0073] Glyceryl monostearate 15g

[0074] Makes 1000 capsules

[0075] Preparation method: Take Ubenimex fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten glyceryl monostearate base, mix well, use ice water as a coolant, make pellets by drop method, and dry to obtain .

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PUM

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Abstract

The present invention utilizes ultramicropulverization and dripping pill preparation production process to make ubenimex dripping pills, and can attain the goal of raising disintegration and dissolution speed, quickly obtaining therapeutic effect, raising stability of medicine, reducing dose of auxiliary material, reducing production cost and convenient administration. Said pill not only can be sucked, and can be swallowed, and its compliance property is good.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to Ubenimex dripping pills and a preparation method thereof. Background technique [0002] Ubenimex is a compound isolated from the culture fluid of Streplomyces of ivorecticuli, which can competitively inhibit aminopeptidase B (aminopeptidase B) and leucineaminopeptidase (Leucineaminope Ptidase). Enhance the function of T cells, enhance the killing activity of NK cells, and increase the synthesis of colony-stimulating factors to stimulate the regeneration and differentiation of bone marrow cells, interfere with the metabolism of tumor cells, inhibit tumor cell proliferation, and induce tumor cell apoptosis. Activate the immune function of human cells, stimulate the production and secretion of cytokines, and promote the production and proliferation of anti-tumor effector cells. [0003] Ubenimex is well and rapidly absorbed after oral administration, ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/197A61P35/00
Inventor 钱进许军彭红李平朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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