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Lucid ganoderma spore powder polysaccharide, production method and use

A technology of Ganoderma lucidum spore powder and production method, which are applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, organic active ingredients, etc., can solve problems such as unreported, and achieve enhanced immune activity, simple extraction and separation method, and high yield. high effect

Inactive Publication Date: 2004-07-21
SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies on the polysaccharide components in the crude drug of the spore powder and the broken spore powder have been reported, but the research on the polysaccharide in the microwave softened spore powder has not been reported

Method used

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  • Lucid ganoderma spore powder polysaccharide, production method and use
  • Lucid ganoderma spore powder polysaccharide, production method and use
  • Lucid ganoderma spore powder polysaccharide, production method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Soak 100 g of dried Ganoderma lucidum spore powder softened by microwave at room temperature for 24 hours with 1 liter of deionized water, and filter. The filtrate was concentrated under reduced pressure at 50°C to 200-300 ml. Then precipitate with 95% ethanol, the final concentration of ethanol is 85%, and precipitate for 24 hours. Centrifuge, dissolve the precipitate with 200-300 ml of water, centrifuge, and dialyze with deionized water for 48-72 hours. Concentrate under reduced pressure at 50°C and freeze-dry to obtain 1.5 g of total sugar LzPS of Ganoderma lucidum spores with a purity of 69%.

Embodiment 2

[0037]100 g of dried Ganoderma lucidum spore powder softened by microwaves was boiled with 1 liter of deionized water at 80-90° C. for 1 hour, and filtered. The filtrate was concentrated under reduced pressure at 50°C to 200-300 ml. Then precipitate with 95% ethanol, the final concentration of ethanol is 85%, and precipitate for 24 hours. Centrifuge, dissolve the precipitate with 200-300 ml of water, centrifuge, and dialyze with deionized water for 48-72 hours. Concentrate under reduced pressure at 50°C and freeze-dry to obtain 2.1 g of total sugar LzPS of Ganoderma lucidum spores with a purity of 67%.

Embodiment 3

[0039] Add 150 ml of water to dissolve Ganoderma lucidum spore total sugar LzPS, add 2 times of 95% ethanol under stirring, overnight, centrifuge and dissolve the precipitate in 50 ml of water, dialyze with deionized water for 24 hours, centrifuge, concentrate under reduced pressure, freeze-dry Obtain the first fraction LzPS-a 0.26g with a purity of 68%, add 3 times of 95% ethanol to the supernatant and process the same as above to obtain the second fraction LzPS-b 0.20g with a purity of 76%, add 5 times of 95% ethanol to the supernatant The third fraction LzPS-c 0.21g with a purity of 70% was obtained by the same treatment as above, and the supernatant was added with 7 times of 95% ethanol to obtain the fourth fraction LzPS-d 0.18g with a purity of 88%.

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Abstract

A ganoderma spore polyose LzPS-1 with anticancer and immunity improving functions is prepared from the ganoderma spora through softening by microwave, extracting in water, depositing in organic solvent, dissolving deposit in water, dialysis or membrane separation of supernatant, concentrating and drying to obtain common saccharide, depositing stage by stage, and chromatography. Its advantages are high output rate, high curative effect and no toxic by-effect.

Description

technical field [0001] The invention relates to a homologous mixture of polysaccharides extracted from traditional Chinese medicinal materials by biotechnology, in particular to Ganoderma lucidum spore powder polysaccharide LzPS-1 extracted from ganoderma lucidum spore powder softened by microwaves, its production method and application. technical background [0002] Ganoderma lucidum is the general name of red lucidum and purple lucidum, fungi of the genus Ganoderma lucidum of the basidiomycete polyporaceae family. In recent years, with the development of artificial cultivation technology of Ganoderma lucidum, the problem of large-scale collection of its germ cells-spores has been solved, which provides a stable source of raw materials for the research and development of its chemical composition and medicinal value. According to reports, Ganoderma lucidum spores have hypoglycemic effect [Zhang Linghua, et al. Chinese Herbal Medicine, 1993, 24(5): 246] and can regulate the i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/716A61P35/00A61P37/04C08B37/02
Inventor 吕龙田庚元王浩邓军娥张劲松
Owner SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
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