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Bicarbonate-based solutions for dialysis therapies

A bicarbonate and lactate technology, used in peritoneal dialysis, dialysis systems, pharmaceutical formulations, etc., can solve problems such as unfavorable precipitation, hinder normal use, discomfort and ARF reaction time sensitivity, and reduce time and work consumption. Effect

Inactive Publication Date: 2004-05-12
NIKKISO COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, due to the initial preparation of a bicarbonate concentrate, its addition to another solution, and manual injection of other components to form a bicarbonate-based solution prior to administration to a patient, the actual processing described above may be too much. Cumbersome and time-consuming, unsuitable for dealing with time sensitivity to ARF responses in intensive care settings
Such manipulations may also inevitably lead to the decomposition of bicarbonate into volatile carbon dioxide gas and carbonate ions, which can then react with calcium and magnesium ions in solution to form unfavorable precipitates, thus preventing normal use
Also, unless strict sterilization techniques are followed during preparation, bicarbonate-based solutions have a high potential for bacterial contamination

Method used

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  • Bicarbonate-based solutions for dialysis therapies
  • Bicarbonate-based solutions for dialysis therapies

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

Large chamber (buffer)

7.4-7.6

mixture

7.2-7.3

[0061] Example 1 identifies three different bicarbonate-based solution formulations formulated in accordance with embodiments of the present invention. Tables 1A and 1B show the final or reconstituted bicarbonate-based solution formulations expressed in mmol / L (Table 1A) or g / L (Table 1B).

[0062] Table 1C shows the amount of electrolyte concentrate (expressed in g / L in the upper half of Table 1C and mmol / L in the lower half of Table 1C) for each formulation prior to mixing with the bicarbonate concentrate express). Table 1D shows the content of bicarbonate concentrate (expressed in g / L in the upper half of Table 1D and mmol / L in the lower half of Table 1D) for each formulation before mixing with the electrolyte concentrate express). Table 1E shows the pH of the mixed solution (e.g., Formulations 1-3), the pH of the small chamber before mixing (e.g., electrolyte concentrate) and the pH of t...

Embodiment 2

mixture

7.1-7.3

[0067] Example 2 illustrates examples of formulations 1-3 (see, Tables 1A and 1B) prepared by mixing bicarbonate concentrate and electrolyte concentrate under extreme pH conditions according to an embodiment of the present invention.

[0068] Table 2A shows the content of bicarbonate concentrate (expressed in g / L in the upper half of Table 2A and mmol / L in the lower half of Table 2A) for each formulation before mixing with the electrolyte concentrate express). Table 2B shows the amount of electrolyte concentrate (expressed in g / L in the upper half of Table 2B and mmol / L in the lower half of Table 2B) for each formulation prior to mixing with the bicarbonate concentrate express). Table 2C shows the pH of the mixed solution (e.g., Formulations 1-3) measured under extreme pH conditions, the pH of the small chamber before mixing (e.g., bicarbonate concentrate) and the pH of the large chamber before mixing (e.g., electrolyte concentrate).

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Abstract

Bicarbonate containing solutions for use during medical treatment are provided. The bicarbonate containing solution of the present invention includes at least two separate components including a bicarbonate concentrate and an electrolyte concentrate which can be readily and sterilely mixed to form a ready-to-use formulation for patient administration, particularly as applied to the treatment of acute renal failure associated with critically ill patients in an intensive care setting.

Description

Background of the invention [0001] The present invention relates generally to therapeutic drugs. More particularly, the present invention relates to bicarbonate-based solutions for use in dialysis therapy, such as continuous renal replacement therapy. [0002] A number of different therapeutic agents are known to treat critically ill patients with acute renal failure (ARF), which is often accompanied by multiple organ failure complications in intensive care settings. Conventional dialysis treatments such as hemodialysis and peritoneal dialysis are often used to treat ARF. [0003] However, due to the limited application of conventional dialysis therapy in the treatment of severe ARF patients, continuous renal replacement therapy (CRRT) is used to support routine dialysis therapy, especially in intensive care settings. In this regard, it has been recognized that CRRT may have several advantages over conventional dialysis treatment. [0004] The most important advantage is th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K33/14A61M1/14A61P13/12
CPCA61K33/14A61P13/12A61P7/08A61K9/08A61M1/28
Inventor 保拉·伊丽莎白蒂尼让-保罗·梅内盖尔热罗姆·科拉斯克里斯蒂安·勒诺乔斯·迪维诺德克·费伊莎贝尔·维尔梅
Owner NIKKISO COMPANY
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