Nebcin inhalation powder mist agent and its preparation method

Abstract

A powder inhalant of gernebcin for treating the pseudomonads infection to lung of the cystic fibrosis patient is prepared from the superfine gernebcin powder and superfine medical carrier through proportionally mixing and loading in container. Its advantage is high safety and curative effect.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and its preparation method, in particular, tobramycin inhalation powder and its preparation method. Background technique [0002] Tobramycin is an aminoglycoside antibiotic with an antibacterial spectrum similar to that of gentamicin. Gram-negative bacteria such as Pseudomonas, some Neisseria, some achromatic Serratia and Shigella have antibacterial effect; Tobramycin has stronger antibacterial effect on Pseudomonas aeruginosa than gentamicin3 -5 times, Pseudomonas aeruginosa, which is moderately sensitive to gentamicin, is highly sensitive to tobramycin. Among Gram-positive bacteria, Staphylococcus aureus (including β-lactamase-producing strains) is sensitive to tobramycin; medicine. Anaerobes (Bacteroides), Mycobacterium tuberculosis, Rickettsiae, viruses and fungi are also resistant to tobramycin. [0003] The mechanism of action of tobramycin is to bind to the 30S subunit of the bacterial ri...

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Problems solved by technology

[0033] TOBI  Although it shows a good clinical therapeutic effect, its inhalation spray drug delivery device has a complex structure and is not easy to assemble. It is necessary to hold the inhalation sprayer for about 15 minutes for each administration, and the storage condition is 2-8°C. High requirements, inconvenient to carry and use, difficult to coordinate the administration, poor compliance, especially unsuitable for children, bedridden patients, the elderly and patients with dyspnea symptoms and behavioral disorders, which limits the therapeutic effect of the drug

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