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Formula of rehmannia root effervescence preparation and process for preparing same

An effervescent preparation, the technology of Rehmannia glutinosa, which is applied in pharmaceutical formulations, anti-inflammatory agents, non-central analgesics, etc., can solve the problems of inconvenient carrying, eating and storage of Rehmannia glutinosa pills, and low bioabsorption rate.

Inactive Publication Date: 2004-03-24
陈善豪 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The invention solves the defects of the existing rehmannia pills that are inconvenient to carry, eat and store, and has a low bioabsorption rate, and provides a formula and a preparation method of an effervescent rehmannia preparation that is convenient to carry, eat and store, and has a high bioabsorption rate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] (1) Extract 320 grams of Rehmannia glutinosa, 160 grams of Cornus officinalis, and 160 grams of Chinese yam in a full-function water-soluble extraction tank to extract the water-soluble components three times, each time for 2 hours, combine the three extracts, filter, and concentrate under low temperature and reduced pressure to a relative density of 1.2- 1.3, granulated by spraying method,

[0011] (2) The acidic and alkaline components of the effervescent disintegrating agent are respectively granulated with 10% starch slurry.

[0012] (3) Mix 400 grams of effervescent disintegrant granules and 500 grams of medicinal granules evenly, press into tablets, and pack in moisture-proof packaging.

[0013] If 1.5-3.5 parts of Rehmannia glutinosa, 1-2.5 parts of Cornus officinalis, 1-2.5 parts of Chinese yam, 0-1.5 parts of Poria cocos, 0-1.5 parts of Moutan cortex, and 0-1.5 parts of Alisma are used as raw materials, the embodiment can also be directly used 1. The full-feat...

Embodiment 2

[0015] (1) After pulverizing 120 grams of Moutan cortex, distill and extract paeonol with water steam, and then make paeonol into granules with cyclodextrin.

[0016] (2) 160 grams of Cornus officinalis was extracted twice with 75% ethanol under reflux, each time for 2 hours, the ethanol extracts were combined, filtered, ethanol was recovered from the filtrate, and the concentrated solution was used for later use.

[0017] (3) Decoct 320 grams of Rehmannia glutinosa, 120 grams of Poria cocos, 160 grams of Chinese yam, 120 grams of Alisma, and the extracted medicinal residues of Cornus officinalis with water for two times, each time for 2 hours, combine the decoction liquid, refine and filter, The filtrate is concentrated under reduced pressure to a relative density of 1.1-1.2; it is combined with the concentrated solution of (2), granulated by spraying, coated, and set aside.

[0018] (4) Mix (1) granules with (3) granules.

[0019] (5) The acidic and alkaline components of t...

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Abstract

The present invention is composed of (by weight) 1.5-3.5 portions of cooked rehmannia root, 1-2.5 portions of cornus fruit, 1-2.5 portions of Chinese yam, 0-1.5 portions of moutan root bark, 0-1.5 portions of poria and 0-1.5 portions of alisma tuber, and adopts the distillation method, alcohol extraction method and water extraction method to separately extract their effective components, then makes them undergo the processes of refining, filtering, concentrating, granulating, the coating or non-coating; granulating effervescent disintegrant, coating or non-coating, mixing the above-mentioned all the materials uniformly, tableting and packaging so as to obtain the invented rehmannia effervescent preparation for curing and preventing oral diseases.

Description

(1) Technical field: [0001] The invention relates to a formula of rehmannia effervescent preparation and a preparation method thereof. (two) background technology: [0002] Liuwei Dihuang Wan (formerly known as Dihuang Wan) is composed of six traditional Chinese medicines: Rehmannia glutinosa, Cornus officinalis, Chinese yam, Alisma, Poria and paeonol. It was first recorded in "Pediatric Medicine Syndrome Zhi Jue" in the Song Dynasty, and it was still collected and recorded until the 2000 edition of "Pharmacopoeia of the People's Republic of China". It has been used for nearly a thousand years and is a very famous Chinese patent medicine prescription. The formula is based on the principle of traditional Chinese medicine "jun, minister, adjuvant, and envoy". It mainly focuses on nourishing the kidney, supplementing the kidney, liver and spleen, three tonics and three diarrhea. Due to changes in work and life, the symptoms of deficiency of kidney, liver and spleen, and intern...

Claims

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Application Information

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IPC IPC(8): A61K9/46A61P1/14A61P3/06A61P3/10A61P9/06A61P9/12A61P35/00A61P37/04
Inventor 陈善豪陈海皎
Owner 陈善豪
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