Cetirizing hydrochloride cataplasm preparation
A technology of cetirizine hydrochloride and hydrochloric acid, which is applied in the field of medicine to achieve the effects of reducing blood drug concentration, convenient use, and reducing the number of administrations
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Embodiment 1
[0011] Embodiment 1 prepares cetirizine hydrochloride cataplasm
[0012] Formula and ratio:
[0013] Gelatin 2g Carborite7S 0.4g
[0014] Sodium Carboxymethyl Cellulose 4g Ca(OH) 2 0.24g
[0015] Polyvinylpyrrolidone 6g Propylene glycol 20ml
[0016] D-Sorbitol 38g Kaolin 4g
[0017] 60ml distilled water 8g menthol
[0018] Glycerin 8ml Citric acid (10%) 0.5ml
[0019] Polyethylene glycol-200 1g Cetirizine hydrochloride 0.6g
[0020] The preparation method is:
[0021] 1. Prepare (I) phase solution: fully swell the gelatin with water according to the above ratio, dissolve it in a water bath at 60°C, mix the sodium carboxymethylcellulose, polyvinylpyrrolidone, and D-sorbitol evenly, and then add it to the gelatin solution. Stir to obtain (I) phase solution.
[0022] 2. Prepare (II) phase solution: dissolve menthol in propylene glycol, mix with Carborite7S, Ca(OH) 2 , kaolin, citric acid, and cetirizine hydrochloride are un...
Embodiment 2
[0024] Embodiment 2 Preparation of cetirizine hydrochloride cataplasm
[0025] Formula and ratio:
[0026] Gelatin 2g Carborite7S 0.2g
[0027] Sodium Carboxymethyl Cellulose 4g Al(OH) 3 0.18g
[0028] Polyvinylpyrrolidone 4g Propylene Glycol 20ml
[0029] D-Sorbitol 32g Zinc Oxide 4g
[0030] Distilled water 60ml Camphor 6g
[0031] Glycerin 10ml Citric acid (20%) 0.4ml
[0032] Isopropanol 1g Cetirizine Hydrochloride 0.6g
[0033] The preparation method is:
[0034] 1, prepare (I) phase solution (same as embodiment 1).
[0035] 2. Prepare (II) phase solution: dissolve camphor in propylene glycol, add Carborite7S, Al(OH) 3 , zinc oxide, citric acid, and cetirizine hydrochloride were uniformly mixed to obtain (II) phase solution.
[0036] 3. Mix (I) and (II) phase solutions, add 10ml glycerin, 1g isopropanol, stir well, spread on 150×240cm 2 On non-woven fabric, bake at 50°C for 30 minutes, cover with anti-adhesive film,...
Embodiment 3
[0037] Embodiment 3 prepares cetirizine hydrochloride cataplasm
[0038] Formula and ratio:
[0039] Gelatin 2g Carborite7S 0.6g
[0040] Sodium carboxymethylcellulose 3g AlCl 3 0.2g
[0041] Polyvinylpyrrolidone 6g Propylene glycol 20ml
[0042] D-Sorbitol 36g Kaolin 6g
[0043] Distilled water 80ml Azone 8g
[0044] Glycerin 10ml Citric acid (50%) 0.2ml
[0045] Oleic acid 0.5g Cetirizine hydrochloride 0.6g
[0046] The preparation method is:
[0047] 1, prepare (I) phase solution (same as embodiment 1).
[0048] 2. Prepare II) phase solution: mix azone, propylene glycol with Carborite7S, AlCl 3 , kaolin, citric acid, and cetirizine hydrochloride are uniformly mixed to obtain (II) phase solution.
[0049] 3. Mix (I) and (II) phase solutions, add 10ml glycerin, 0.5g oleic acid, stir well, spread on 150×240cm 2 On non-woven fabric, bake at 50°C for 30 minutes, cover with anti-adhesive film, cut into 5×8cm 2 The catapl...
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