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Process for preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties

A technology of hydrophilic polymers and adhesives, applied in the direction of amide/imide polymer adhesives, adhesive types, polyether adhesives, etc., can solve problems such as loss of adhesion

Inactive Publication Date: 2003-10-29
A V TOPCHIEV INST OF PETROCHEM +5
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hydrophilic treatment of hydrophobic adhesives is effective, but causes partial loss of adhesiveness

Method used

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  • Process for preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties
  • Process for preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties
  • Process for preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties

Examples

Experimental program
Comparison scheme
Effect test

example 1-16

[0121] Preparation of PSA substrates by mixing PVP with PEG-400: effects on the composition, hydration and thickness of the adhesive layer

[0122] A bond coat with a thickness of 250-300 microns was prepared by dissolving a hydrophilic polymer and PEG (Mw=400) in a common solvent (ethanol), and casting the solution onto a backing sheet and drying. Unsupported PVP-PEG hydrogels were obtained by casting the respective solutions onto release liners followed by room temperature drying.

[0123] The bonding point strength of the adhesive hydrogel and a standard polyethylene (PE) sheet with a thickness of 100 m was evaluated by a 180° peel test using an Instron 1221 tensile strength tester at a peel rate of 10 mm / min. The crystallinity is 45%, the contact angle is 105°, and the surface energy is 28.5mJ / m 2 Low density PE is used as standard base material. The adhesive is saturated with water: control the water vapor pressure to 50% in a desiccator at room temperature, and equilib...

example 17-47

[0132] Preparation of PSA substrates by mixing PVP with different short-chain plasticizers

[0133] Component Action and Adhesion vs. Phase State

[0134] Using the preparation method and evaluation test method described in Example 1, samples of PVP K-90 mixed with various plasticizers were obtained and tested at 50% RH and room temperature. The results are shown in Table 3. Viscous mixtures can be obtained by mixing PVP with hydroxyl-terminated (Examples 17-41 ) or carboxy-terminated (Examples 42-47) short-chain plasticizers. Short-chain plasticizers include: ethylene glycol (Examples 17-19) and its polymers (PEG) in the molecular weight range of 200-600 g / mol (Examples 20-23); low molecular weight 1,3- and 1,2- Propylene glycol (PG) (Examples 24, 25), and alkanediols, from Propylene Glycol to Pentylene Glycol (PD) and Hexylene Glycol (HD) (Examples 27-39). Polypropylene glycol (PPG) was found to be a good plasticizer for PVP, but did not develop any tack or adhesion (Exam...

example 48-64

[0136] Preparation of PSA compositions by mixing different hydrophilic polymers with complementary short-chain plasticizers

[0137] These examples illustrate that not only PVP but also a collection of different hydrophilic polymers become sticky once mixed with short chain plasticizers having complementary reactive groups at the chain ends. Suitable hydrophilic polymers include poly(N-vinylamides) such as, PVP (Examples 1-47), poly(N-vinylcaprolactam) (PVCap) (Examples 48-52) and poly(N-vinyl Acetamide) (PVAA, Example 53), poly(N-alkylacrylamide), examples are poly(N-isopropylacrylamide) (PNIPAM, Example 54), polymethacrylic acid and polyacrylic acid (PMA, PAA , Examples 55-60) and their copolymers, examples are shown in Table 4 (Luviscols VAP(R), available from BASF, Examples 61-64). Luviscol VAP37 is a copolymer of vinylpyrrolidone (VP, 30%) and 70% vinyl acetate (VA). Luviscol VAP 73 contains 70% VP and 30% VA.

[0138] Among the polymers shown in Table 4, it was found ...

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Abstract

A method for preparing hydrophilic pressure sensitive adhesive (PSA) compositions is provided, wherein the method enables preparation of adhesives having a particular, optimized degree of adhesion. That is, the hydrophilic PSA is comprised of a hydrophilic polymer and a complementary short-chain plasticizing agent, wherein the hydrophilic polymer and plasticizing agent are capable of hydrogen bonding or electrostatic bonding to each other and are present in a ratio that optimizes key characteristics of the adhesive composition, such as adhesive strength, cohesive strength and hydrophilicity. The adhesive is useful in a wide variety of contexts, e.g., as a biomedical adhesive for application to the skin or other body surface, and as such finds utility in the areas of drug delivery systems (e.g., topical, transdermal, transmucosal, iontophoretic), medical skin coverings and wound healing products and biomedical electrodes.

Description

technical field [0001] The invention relates to a preparation method of an adhesive composition. More precisely, the present invention relates to a process for the preparation of a hydrophilic pressure sensitive adhesive (PSA) composition having optimal adhesive properties, which can be used, for example, to adhere to skin or other Transdermal drug delivery systems and other medical, pharmaceutical and cosmetic products on body surfaces. The invention can be used in various fields, including transdermal drug supply, iontophoresis system, preparation of biomedical electrodes, wound healing, skin care and cosmetics. technical background [0002] Pressure sensitive adhesives are well known and have been used for many years in a variety of applications including industrial, consumer and medical. Pressure sensitive adhesives are typically characterized by a tack that sticks immediately when applied to a substrate. A variety of polymers have been used to make pressure sensitive...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/32A61K47/34A61L15/58C08F2/00C09J133/24C09J133/26C09J139/04C09J139/06C09J157/00C09J171/02C09J201/00
CPCA61K9/7053A61L15/58C08L39/04C08L29/04C08L33/00
Inventor 米哈伊尔M·弗尔德斯坦恩尼古拉尔A·普累特安即托利E·查利基尔加利W·克利里
Owner A V TOPCHIEV INST OF PETROCHEM
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