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Chinese medicine positioning preparation for curing ulcerative colitis

A technology for colon-localized preparations and ulcerative colitis, which is applied in drug delivery, drug combination, and medical formula, and can solve the problems of inconvenient traditional Chinese medicine enema treatment, affecting patient treatment compliance, and affecting the use of chemical drugs. Systemic adverse reactions, improved compliance, and convenient treatment

Inactive Publication Date: 2003-07-09
BEIJING ZHONGHUI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Because the disease is easy to relapse, long-term medication is required, and the side effects will affect the use of chemical drugs
Most patients require traditional Chinese medicine treatment. There are many traditional prescriptions that use decoction to treat ulcerative colitis with traditional Chinese medicine. The general effect is not ideal, and there are certain side effects on the gastrointestinal tract
Treating ulcerative colitis with traditional Chinese medicine enema has the advantages of quick effect and safety. At present, there are many compound preparations of traditional Chinese medicine enema for clinical treatment of ulcerative colitis, but the treatment method of traditional Chinese medicine enema is very inconvenient, which affects the compliance of patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: Take 150 grams of Sophora flavescens, 60 grams of Radix Glycyrrhizae, and 150 grams of Burnet Burnet, mix the decoction with 60 grams of white powder, dry, pass through a 60-mesh sieve, and pack into ordinary capsules, the capsule capacity is 0.6 grams / grain. The PH-dependent colon localization coating film is outsourced, and the coating liquid adopts 50 grams of acrylic resin, 2200 grams of ethanol, 25 grams of diethyl phthalate, and 24 grams of talcum powder. According to clinical trials, take orally twice a day, 5 capsules each time, 7 days as a course of treatment. Observe 1-4 courses of treatment, the total effective rate is 75%.

Embodiment 2

[0035] Embodiment 2: Take 120 grams of Cortex Phellodendri, 150 grams of Sophora Sophorae, 150 grams of Burnet Ulmus, and 60 grams of Glycyrrhiza Radix Glycyrrhizae, and decoct them together. The decoction is dried and passed through a 60-mesh sieve, and packed into colon-positioning capsules, with a capacity of 0.6 grams per capsule. According to clinical trials, take orally twice a day, 5 capsules each time, 7 days as a course of treatment. After observing 1-4 courses of treatment, the total effective rate is 71%.

Embodiment 3

[0036] Embodiment 3: Get 120 grams of Burnet burnet and 120 grams of Cortex Phellodendri, decoct in water, dry the decoction, mix with 200 grams of Baiji, pass through a 60-mesh sieve, and pack into ordinary capsules, each containing 0.6 grams. Outsourcing PH-dependent colon-localized coating film, the coating solution is made of polymethacrylate EUDRAGIT  S 100: 65 grams, talc powder 32 grams, triethyl citrate 5.8 grams, water 55 grams, isopropanol 900 grams. According to clinical trials, take orally twice a day, 5 capsules each time, 7 days as a course of treatment. Observe 1-4 courses of treatment, the total effective rate is 88%.

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PUM

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Abstract

The present invention relates to a Chinese medicine location preparation for curing ulcerative colitis. It is formed from colon location capsule and Chinese medicine compound preparation for curing ulcerative colitis which is held in the capsule. Said capsule does not disintegrated in the stomach and small intestine, and in the colon region whose pH value is greater than or equal to 7.8 it is disintegrated, and the medicine can be released. Said invention can effectively raise the biological utilization rate of the medicine, and its therapeutic effect is obvious. After the prescription of said medicine is changed, it can be used for curing other disease of colon region.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine formulations, and particularly relates to a dosage form for treating colitis. Background technique [0002] Ulcerative colitis (UC) is a chronic colitis of unknown cause, which is customarily called chronic nonspecific ulcerative colitis, or ulcerative colitis. The disease is currently on the rise and is a difficult disease. [0003] After the first attack of the disease, about 10% of patients can get remission, which can last for 15 years. Another 10% of patients can continue to suffer from active colitis for a long time. Most of the other patients (80%) can alternate between remission and attack, and do not heal for a long time. It can become cancerous in the late stage, which is very frightening. Long-term consumption and torture have caused strong mental and physical damage to patients. [0004] There is no specific treatment at present, and commonly used western medi...

Claims

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Application Information

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IPC IPC(8): A61K9/58A61K35/64A61P1/04
Inventor 朱德权梁秉文马建国
Owner BEIJING ZHONGHUI PHARM CO LTD
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