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Freeze-dried minocycline hydrochloride powder injection and its preparing process

A technology of minocycline hydrochloride and freeze-dried powder injection, which is applied in the field of broad-spectrum antibacterial drugs, and can solve problems such as difficult timely treatment, slow onset of effect, and narrow application range

Inactive Publication Date: 2003-01-15
于航
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the preparation of this product is a tablet, which has the following disadvantages compared with the powder injection: 1. The onset of the tablet is slow during use; 2. It has a strong gastrointestinal tract reaction; 3. It requires a lot of drinking water; 4. The application range is narrow. Tablets are difficult for patients with swallowing disorders to swallow, and it is difficult to treat them in time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] (1) Preparation prescription:

[0012] Minocycline hydrochloride 108g

[0013] Mannitol 210g

[0014] 0.1mol / l hydrochloric acid appropriate amount

[0015] Add water for injection to 3000ml

[0016] Made into 1000

[0017] (2) Preparation process: add the prescription amount of minocycline hydrochloride and mannitol to 2500ml water for injection, stir to dissolve, adjust the pH to 2.0~3.5 with 0.1ml / l hydrochloric acid, add 0.1% solution amount of activated carbon for injection, stir at room temperature After 15 minutes, filter the supplementary water for injection to 3000ml, pass through a 0.2um microporous membrane, and after determining the content, fill it into a 7ml control bottle, 3ml each. After filling, put it in a freeze dryer, first reduce the temperature to -45℃, keep it for 2 hours, then vacuum, and increase the temperature at about 2℃ / hour, when the temperature reaches -5℃, press 5℃ / hour Warm up to 25°C, keep it wa...

Embodiment 2

[0019] (1) Preparation prescription:

[0020] Minocycline hydrochloride 108g

[0021] 210g dextrose

[0022] Acetic acid

[0023] Add water for injection to 3000ml

[0024] Made into 1000

[0025] (2) Preparation process: same as in Example 1.

Embodiment 3

[0027] Minocycline hydrochloride 108g

[0028] Hydrolyzed gelatin 210g

[0029] Phosphoric acid

[0030] Add water for injection to 3000ml

[0031] Prepare 1000

[0032] Preparation process: the same as in Example 1.

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PUM

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Abstract

A freeze dried minocycline hydrochloride powder as antibacterial injection is prepared from minocycline hydrochloride (0.05-10 wt.portions), freeze dried power supporting agent (10-100) and pH regulator. Its advantages are broad antibacterial sprectrum, high stability to light, heat, oxygen and water, and no pollution.

Description

Technical field: [0001] The invention belongs to a broad-spectrum antibacterial drug, and particularly relates to a minocycline hydrochloride freeze-dried powder injection and a preparation method of the injection. Background technique: [0002] Inflammation caused by gram-positive bacteria and gram-negative bacteria, as well as diseases caused by multiple drug-resistant Staphylococcus, Chlamydia, Pseudomonas fluorescens, Flavobacterium and other bacteria, cause great harm to human health, and serious illness It is often difficult to treat patients with other types of antibacterial drugs. Minocycline hydrochloride is a powerful broad-spectrum antibiotic and has excellent antibacterial ability against a variety of drug-resistant bacteria. At present, the preparation of this product is a tablet, which has the following disadvantages compared with powder injection: 1. The onset of action is slow during the use of the tablet; 2. It has a strong gastrointestinal reaction; 3. It requir...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/65A61P31/04
Inventor 于航
Owner 于航
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