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Tissue augmentation material and methods

A tissue enhancement and tissue technology, applied in the field of filling soft tissue voids or producing soft tissue blisters, urethral sphincter reinforcement materials, can solve problems such as respiratory blockage and unsatisfactory sound quality

Inactive Publication Date: 2002-09-18
白奥佛姆公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0022] Mikalin et al. in "Fat Injection for Unilateral Vocal Cord Paralysis", Laryngoscopy, Vol. 101, Pages 4654-4668 (5, 1991)) disclose a general method of injecting polytetrafluoroethylene paste, which is used in unilateral vocal cord paralysis Many disadvantages of the improved sound calibrator in , which included breathing blockage and unsatisfactory sound quality caused by overinjection of Teflon

Method used

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  • Tissue augmentation material and methods
  • Tissue augmentation material and methods
  • Tissue augmentation material and methods

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098] The preparation of embodiment 1 gel

[0099] A mixture of 15% glycerin, 85% water (by total weight of glycerin and water) and 3.25% NaCMC (again by total weight of liquid ingredients) was prepared as follows:

[0100] 9.303 grams of glycerin and 2.016 grams of NaCMC were mixed in a container. The mixture was then slowly added to 52.718 grams of agitated water in a vessel large enough to hold the batch and allow mixing, using an electric mixer, and stirred at medium speed for 30 minutes. The gel was allowed to stand for at least 4 hours.

Embodiment 2

[0101] Embodiment 2 Preparation of Enhanced Composition

[0102] The glycerol / NaCMC hydrogel (44.04 grams prepared in Example 1) was placed in a mixing vessel large enough to hold a batch. Smooth round and substantially spherical CaHA particles (55.99 g) with a uniform particle size of 75-125 microns were mixed thoroughly with an electric mixer at low speed for 5 minutes until a gel-like homogeneous suspension with uniform distribution of all particles was obtained. The mixed material was filled into 3 ml polysulfone cartridges and sterilized in an autoclave at a temperature of 121°C for 60 minutes.

Embodiment 3

[0103] Preparation of embodiment 3 reinforcing material composition

[0104]

prepared gel

increase in preparation

strong composition

increase in disinfection

strong donor

Viscosity (Cp)@500Pa stress

603000

4610000

4340000

Elastic modulus (100Pa@1Hz)

408

2520

2684

Tangent δ(100Pa@1Hz)

0.461

0.453

0.429

gamma 最大

2.227

0.367

0.345

%recover

44.99

45.50

46.96

[0105] A mixture of 25% glycerol, 75% water and 2.25% NaCMC (by total weight of glycerol and water) was prepared as follows:

[0106] 87.90 grams of glycerin and 7.91 grams of NaCMC were mixed in a container large enough to hold the total amount of material. The mixture was then slowly added to 263.71 grams of agitated water in an adequately large container using an electric mixer at medium speed for 30 minutes. The gel was allowed to stand for at least 4 hours.

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Abstract

A permanent biocompatible material for soft tissue reinforcement. The biocompatible material comprises a smooth and round finely divided substantially spherical biocompatible ceramic particles, close to or in contact with each other, which provides a scaffolding structure or structure for autologous tissue, three-dimensional free positioning, in The augmentation site grows soft tissue without scars. The reinforcing material can be uniformly suspended in a biocompatible absorbable smooth gel carrier comprising a polysaccharide. It is used to improve the delivery properties of reinforcement materials injected into the tissue site where reinforcement is desired. Augments are particularly useful for strengthening the urethral sphincter, treating urinary incontinence, filling soft tissue voids, creating soft tissue blisters, treating unilateral vocal cord paralysis and for breast implants. It can be injected subcutaneously, intradermally or can be implanted.

Description

field of invention [0001] The present invention relates to a biocompatible material for reinforcing soft tissue, and more particularly, the present invention relates to a urethral sphincter reinforcing material for treating incontinence, for filling soft tissue voids or creating soft tissue blisters; for breast implants and for Biocompatible material for soft tissue augmentation in the treatment of unilateral vocal cord paralysis. The invention also relates to a gel carrier for the biocompatible composition. Background technique [0002] In the practice of plastic and reconstructive surgery, many biocompatible materials have been proposed for use in augmenting soft tissues, examples of which are collagen, gel beads, natural or synthetic materials such as polytetrafluoroethylene, silicone rubber, etc. Polymer beads and various hydrogel polymers such as polyacrylonitrile-polyacrylamide hydrogels. [0003] Typically, the biomaterial is injected via an injectable composition c...

Claims

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Application Information

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IPC IPC(8): A61K47/36A61K31/74A61K33/06A61K33/10A61K33/24A61K47/10A61K47/38A61L27/00A61L27/46A61L27/50
CPCA61L27/46A61L27/50C04B35/6365C04B35/636C04B35/447C08L1/26C08L5/00
Inventor 威廉·G·哈伯德蒂莫西·R·德万
Owner 白奥佛姆公司
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