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Purification of organic acid using anion exchange chromatography

An anion, inorganic anion technology, applied in separation methods, organic chemistry, separation/purification of carboxylic acid compounds, etc., can solve problems such as increasing the cost of purified acid

Inactive Publication Date: 2001-04-18
MICHIGAN BIOTECH INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So, if the acid form of the molecule is required, the method used must include an acidification step and additional purification steps which add significantly to the cost of purifying the acid

Method used

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  • Purification of organic acid using anion exchange chromatography
  • Purification of organic acid using anion exchange chromatography
  • Purification of organic acid using anion exchange chromatography

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0040] Obtain succinate from fermented broth

[0041] Total amount of succinic acid in fermentation broth before ion exchange = 4 kg

[0042] Volume of succinic acid broth before ion exchange = 4 liters

[0043] Succinate concentration determined by HPLC = 58.14 g / L

[0044] Lactate concentration determined by HPLC = 5.05 g / L

[0045] Acetate concentration determined by HPLC = 3.89 g / L

[0046]Fermentation Broth pH =

[0047] Amount of succinate (retention solution) after ion exchange = 19.2 kg

[0048] Volume of succinate solution (retention solution) after ion exchange = 19.2 liters

[0049] Succinate concentration determined by HPLC = 4.28 g / L

[0050] Lactate concentration = 0.23 g / L

[0051] Acetate concentration = 0.34 g / L

[0052] Retention solution pH =9.3

[0053] Ion exchange column bed volume = 7 liters

[0054] Ion Exchange Column Diameter =4″

[0055] Flow rate = 21.6 liters / hour

[0056] =3BV / hr

[0057] The ...

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Abstract

Disclosed is a cost-effective method for purifying and acidifying carboxylic acids, including organic acids and amino acids. The method involves removing impurities by allowing the anionic form of the carboxylic acid to bind to an anion exchange column and washing the column. The carboxylic anion is displaced as carboxylic acid by washing the resin with a strong inorganic anion. This method is effective in removing organic carboxylic acids and amino acids from a variety of industrial sources, including fermentation broths, hydrolysates, and waste streams.

Description

Background of the invention [0001] Industrial fermentation broths, hydrolysates and waste liquors are substantial sources of carboxylic acids including organic acids such as succinic acid and amino acids. These carboxylic acids are used in many important commercial applications. [0002] For example, succinic acid, a four-carbon dicarboxylic acid, is likely to become an important chemical commodity. Succinic acid is useful as an intermediate in the synthesis of many important intermediates and as a specialty chemical in the consumer goods industry. As a daily chemical, succinic acid can replace many benzene-based daily necessities and petrochemical intermediates, which can lead to a significant reduction in pollution caused by the production and consumption of more than 250 benzene-derived chemicals. Succinic acid is used as a food additive, as a plant growth stimulant, as an intermediate in the production of pharmaceuticals, and as a polymer and resin for the production of ...

Claims

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Application Information

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IPC IPC(8): C07C51/42B01D15/04C07C51/47C07C53/08C07C55/10C07C59/265C11B3/10C11B13/00C11C1/08
CPCC07C51/47C07C59/265C07C53/08C07C55/10C07C59/08C07C51/42B01D15/00
Inventor E·庞南帕拉马
Owner MICHIGAN BIOTECH INST
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