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Elsholizia extract capsule for treating diarrhea and its prepn

A quality control method, the technology of fenugreek, which is applied in the direction of medical preparations containing active ingredients, drug combinations, and pharmaceutical formulas, can solve the problem of drugs. There are reports abroad that Lactobacillus, interferon, ribavirin, etc. are used for treatment, and there are domestic reports. , lack of special effects, etc.

Inactive Publication Date: 2006-11-08
张瑞祥
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is still no effective drug for viral diarrhea. There are reports abroad that Lactobacillus, interferon, ribavirin, etc. are used for treatment. In China, chickens are infected with viruses and antibody preparations are prepared from chicken eggs for treatment, but they are still under development. middle

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example

[0024] Experimental example: the effect of Mora capsule on inhibiting children's rotavirus ROTA-I type (Wa strain)

[0025] Materials and Methods:

[0026] 1. Drugs: Mora Capsules as the test drug, Mora oil used directly in the test, light yellow, specific gravity 0.95726g / ml, 16mg oil / g crude drug, batch number: 20000601, provided by Beijing Jushan Pharmaceutical Research Institute. Take 0.5ml Mora oil and 0.5ml Tween-80 (manufactured by Shanghai No. 18 Pharmaceutical Factory, batch number: 960520) and mix well, then add 4ml growth medium to dilute. Put in a 4°C refrigerator for later use.

[0027] The control drug Gegen Qinlian Micropills was produced by Guangxi Liuzhou Traditional Chinese Medicine Factory, Guiwei Zhunzi (1991) No. 017004, batch number: 990721. Take 1 g of medicine and add 10 ml of distilled water to dissolve, centrifuge at 2000 rpm for 10 minutes, take the supernatant and boil it in a water bath for 10 minutes to sterilize, and store it in a refrigerator ...

Embodiment 1

[0054] Example 1: Take 50 g of Mora oil, add 50 ml of ethanol, and stir well: Take 300 g of β-cyclodextrin, add 900 ml of water to dissolve, slowly add the above-mentioned volatile oil solution under heat preservation and stirring at 40 ° C, heat heat and stir for 5 minutes, pass through a colloid mill Inclusion 3 times, refrigerated for more than 12 hours, suction filtered, air-dried at 40°C for 6 hours, sieved, added 1g of magnesium stearate, mixed evenly, packed into capsules, and made into 1000 capsules. Each capsule contains 0.35g, 3 times a day, 2 capsules each time.

Embodiment 2

[0055] Embodiment 2: Mora capsule quality control method

[0056] Determination of content: Determination according to high performance liquid chromatography (Appendix VI D of Chinese Pharmacopoeia 2000 edition). Chromatographic conditions and system suitability test Octadecylsilane bonded silica gel was used as filler; 60:40:2 methanol-water-glacial acetic acid was used as mobile phase; detection wavelength was 276nm. The number of theoretical plates should not be less than 10,000 based on the thymol peak, and not less than 15,000 based on the carvacrol peak. Preparation of Reference Substance Solution Precisely weigh 8 mg of thymol reference substance and 4 mg of thymol reference substance, put them in a 100ml measuring bottle, add methanol to the mark, and shake well to obtain. Each ml contains 80 μg of thymol and 40 μg of carvacrol . Preparation of the test solution Take the content under the difference in loading amount, grind it finely, take 0.12g, accurately weigh it,...

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PUM

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Abstract

The invention discloses a capsule preparation of the volatile oil of fenugreek and a quality control method thereof. The capsule preparation of the volatile oil of the fenugreek has anti-virus, anti-bacterial, anti-inflammatory, antidiarrheal, pain-relieving and antipyretic effects, and can inhibit gastrointestinal hyperfunction .

Description

technical field [0001] The present invention relates to a traditional Chinese medicine extract preparation and a preparation method thereof, in particular to a capsule preparation of the extract of Cyperus argentina for treating diarrhea and a preparation method thereof. Background technique [0002] Diarrhea (infectious, non-infectious) has a high morbidity rate and, in some areas, a high mortality rate, which is a serious problem throughout the world. The treatment of diarrhea in traditional Chinese medicine is based on syndrome differentiation. For those with cold-dampness syndrome, Huoxiangzhengqi San is the main prescription; for damp-heat syndrome, Gegen Qinlian Decoction is the main prescription; for food stagnation syndrome, Baohe Wan is the main prescription; Mainly, Shenlingbaizhusan is the main medicine for spleen and stomach deficiency syndrome, and Sishen Pill is the main medicine for kidney yang deficiency syndrome. However, there are also those who use soil s...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61P1/12
Inventor 张瑞祥仝燕刘建勋李彩熙
Owner 张瑞祥
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