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Method of preparing hud typed Nano/micron fibers or capsules for use of slow releasing medication

A micro-fiber, core-shell type technology, applied in the direction of microcapsules, capsule delivery, pharmaceutical formulations, etc., can solve the problems of restricting wide application, and achieve the effect of low energy consumption and simple process

Inactive Publication Date: 2006-11-08
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above shortcomings of electrospun membranes or capsules limit their wide application in the field of controlled drug release.

Method used

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  • Method of preparing hud typed Nano/micron fibers or capsules for use of slow releasing medication
  • Method of preparing hud typed Nano/micron fibers or capsules for use of slow releasing medication
  • Method of preparing hud typed Nano/micron fibers or capsules for use of slow releasing medication

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Polycaprolactone (PCL, Mn 42500, Aldrich) 3g was dissolved in 10ml dimethylformamide (DMF) / chloroform mixed solvent (volume ratio 3 / 7), placed figure 1 In the shown outer chamber; 4g polyethylene glycol (PEG, Mn 35,000, domestic) and 400mg BSA were dissolved in 10ml deionized water, placed in figure 1 In the shown inner chamber; the PCL solution in the outer chamber is extruded out of the spinning head by nitrogen flow, and the PEG solution in the inner chamber is pushed out of the spinning head by a syringe pump, and the applied voltage is 13.0kv. Under the above conditions, a core-shell nanofiber membrane with PCL as the shell and PEG / BSA as the core can be conveniently prepared, with a fiber diameter of about 800 nm.

Embodiment 2

[0025] Polycaprolactone (PCL, Mn 42500, Aldrich) 3g was dissolved in 10ml dimethylformamide (DMF) / chloroform mixed solvent (volume ratio 3 / 7), placed figure 1 In the shown outer chamber; 3g polyvinylpyrrolidone (PVP, Mn 55,000, domestic) and 400mg BSA were dissolved in 10ml deionized water, placed in figure 1 In the inner chamber as shown; the PCL solution in the outer chamber is extruded from the spinning head by nitrogen flow, and the PVP solution in the inner chamber is pushed out of the spinning head by a syringe pump, and the applied voltage is 15.0kv. Under the above conditions, a core-shell nanofiber membrane with PCL as the shell and PVP / BSA as the core can be conveniently prepared, with a fiber diameter of about 750 nm.

Embodiment 3

[0027] Polycaprolactone (PCL, Mn 42500, Aldrich) 3g was dissolved in 10ml dimethylformamide (DMF) / chloroform mixed solvent (volume ratio 3 / 7), placed figure 1 In the shown outer chamber; 2g dextran (Mn 70,000, domestic) and 400mg BSA were dissolved in 10ml deionized water, placed in figure 1 In the shown inner chamber; the PCL solution in the outer chamber is squeezed out of the spinning head by nitrogen flow, and the dextran solution in the inner chamber is pushed out of the spinning head by a syringe pump, and the applied voltage is 14.0kv. Under the above conditions, a core-shell nanofiber membrane with PCL as the shell and dextran / BSA as the core can be conveniently prepared, with a fiber diameter of about 600 nm.

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Abstract

The invention discloses a preparation method of a core-shell nano / micron fiber or capsule for drug sustained release. It adopts a double-layer spinning head composed of inner and outer layers. Oil-soluble, water-soluble drugs or their mixtures and two identical or different polymer solutions pass through the inner and outer layers of the double-layer spinning head respectively. Nano / micro fiber or capsule is formed, oil-soluble, water-soluble drug or their mixture is directly embedded in the outer layer, inner layer or two layers of nano / micro fiber or capsule. The equipment and process required for the preparation of the present invention are simple, and the energy consumption is small; all drugs, including hydrophobic and water-soluble drugs, can be loaded into nano / micro fibers or capsules with a high embedding rate; the preparation conditions are mild, suitable for polypeptide protein, growth Bioactive substances that are variable and inactivated such as factors and DNA; the release rate of drugs can be adjusted; the obtained nano / micro fibers can be directly used as tissue engineering scaffolds for cell culture.

Description

technical field [0001] The invention relates to a method for preparing core-shell nano / micro fibers or capsules for drug sustained release. Background technique [0002] With traditional drug administration methods and pharmaceutical preparations, when the drug is taken, the blood drug concentration increases rapidly, which may exceed the maximum blood drug concentration, and cause certain side effects on normal organs; in addition, because most drugs have a short half-life in the body, After a period of time, the blood drug concentration drops rapidly, below the minimum blood drug concentration, so the real time in the therapeutic window is very short. In clinical practice, it is generally necessary to take a drug at intervals to achieve the purpose of treatment. This way of administration leads to a "peak-valley" phenomenon in the change of blood drug concentration, which is more likely to cause poisoning or no curative effect. Therefore, people prepare drug controlled r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K9/00A61K9/48
Inventor 蒋宏亮胡应乾黎雁赵鹏程朱康杰
Owner ZHEJIANG UNIV
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