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Biodegradable vehicles and delivery systems of biologically active substances

A technology of bioactive substances and biodegradation, which is applied in the field of biodegradable carriers and release systems of bioactive substances, can solve problems such as difficult individualized BAS dosage, and achieve the effect of easy injection and easy preparation

Inactive Publication Date: 2006-11-08
A・J・舒克拉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is therefore often difficult, if not impossible, to individualize the dose of BAS (or vary the BAS loading in these delivery systems)

Method used

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  • Biodegradable vehicles and delivery systems of biologically active substances
  • Biodegradable vehicles and delivery systems of biologically active substances
  • Biodegradable vehicles and delivery systems of biologically active substances

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0062] Example 1 Preparation of biodegradable carrier.

[0063] The polymer (50% w / w 50 / 50 poly(lactic-co-glycolic acid) or poly(lactide-co-glycolide)) was dissolved in a minimum amount of acetone. Then add 50% triethyl citrate (TEC), and stir well. With continuous stirring, the mixture was heated to 60-75°C to evaporate the acetone. The resulting formulation is - a gel-like base.

example 2

[0065] Repeat Example 1 with 10% w / w 50 / 50 poly(lactic-co-glycolic acid) or poly(lactide-glycolide) and 90% w / w TEC to prepare a liquid matrix.

example 3

[0067] Repeat Example 1 with 20% w / w 50 / 50 poly(lactic-co-glycolic acid) or poly(lactide-glycolide) and 80% w / w TEC to obtain a viscous liquid matrix.

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PUM

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Abstract

The present invention provides a biodegradable carrier and delivery system for physiological, pharmacological and biologically active substances (BAS). Biodegradable carriers were prepared by mixing biodegradable polymers with plasticizers by a novel solvent evaporation method. The specific methods include: first dissolving the biodegradable polymer or copolymer and the plasticizer or the mixture of the plasticizer in the volatile solvent or the mixture of the volatile solvent, and then decompressing or heating or both to evaporate the volatile solvent. Biodegradable release systems can be used as fillers or spacers in vivo. BAS can be added at any step during or after the preparation of the biodegradable carrier or before use of the bioreleasable system. The biodegradable release system can control the release of BAS over a desired period of time. The biodegradable carrier or the BAS-loaded biodegradable release system can be injected, implanted, painted or taken to be applied to animals, birds and humans.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Patent Application Serial No. 09 / 605,661, filed June 28, 2000, the teachings of which are incorporated herein by reference. field of invention [0003] The present invention provides biodegradable carriers and delivery systems that can be mixed with one or more physiologically, pharmacologically and biologically active substances (BAS). The biodegradable carrier (without carrying any BAS) can be used as a biodegradable filler or spacer to fill in cavities or tissues in animals, birds and humans. One or more BASs can be mixed with a biodegradable carrier. A delivery system loaded with BAS can be used to control the release of BAS from the delivery system over an extended period of time. The viscosity, rheology, hydrophilicity and hydrophobicity, and in vivo degradation rate of the biodegradable carrier and the release system loaded with BAS ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/00A61K47/30A61F13/00A61K9/00A61K9/06A61K9/08A61K9/16A61K9/22A61K31/00A61K38/00A61K47/08A61K47/10A61K47/14A61K47/16A61K47/22A61K47/32A61K47/34A61K47/42A61L27/00A61L31/04A61L31/14A61L31/16C08L101/16
CPCA61K9/0019A61K9/0024A61K9/06A61K9/1647A61K9/1694A61K31/00A61K47/10A61K47/14A61K47/22A61K47/34A61L31/041A61L31/141A61L31/148A61L31/16A61L2300/602C08K5/11
Inventor A·J·舒克拉
Owner A・J・舒克拉
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