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Biostatic coatings for reduction and prevention of bacterial adhesion

A biological and functional technology, applied in the field of biofunctional structural composites, to achieve the effect of reducing the coefficient of friction

Inactive Publication Date: 2001-01-31
海德罗默公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the aforementioned patents require the use of photochemically reactive groups

Method used

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  • Biostatic coatings for reduction and prevention of bacterial adhesion
  • Biostatic coatings for reduction and prevention of bacterial adhesion
  • Biostatic coatings for reduction and prevention of bacterial adhesion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0089] Biofunctional structure composition of the present invention

[0090] 2 grams of polyurethane polyisocyanate prepolymer (NORDOTAdhesive 34D-2, Synthetic Surfaces, Inc.) prepared by reacting 2 molar excess of diphenylmethane diisocyanate (MDI) with ricinoleic acid ester polyols was mixed with 250 mg of carboxycin (ANGUS Chemical) was mixed in 35 g methyl ethyl ketone. The reaction was monitored by gas chromatography. There was significant consumption of methamphetamine within 8 hours. Infrared analysis shows that at about 2400cm -1 The isocyanate peak disappears. 10 g of tetrahydrofuran, 10 g of N-methylpyrrolidinedione, 30 g of diacetone alcohol, and 3 g of polyvinylpyrrolidinedione (KOLLIDONE 90F, BASF) were added to the solution. Soak the cleaned polyvinyl chloride catheter in the solution for 15 minutes, air dry it for 30 minutes, and then cure it at 80°C for 30 minutes.

[0091] The bacterial adhesion of Staphylococcus aureus on the catheter was detected by the...

Embodiment 3

[0093] Hydrophilic composition of the present invention

[0094] 2 grams of polyurethane polyisocyanate prepolymer (NORDOTAdhesive 34D-2, Synthetic Surfaces, Inc.) prepared by reacting 2 molar excess diphenylmethane diisocyanate (MDI) with ricinoleic acid ester polyol and 35 g of methyl ethyl ketone, 10 g Tetrahydrofuran, 10 g of N-methylpyrrolidinedione, 30 g of diacetone alcohol, and 3 g of polyvinylpyrrolidinedione (KOLLIDONE 90 F, BASF) were mixed. Apply the solution to a clean polyvinyl chloride sheet with a cotton swab. The sheet was air-dried for 30 minutes, and then aged at 80° C. for 30 minutes.

[0095] The bacterial adhesion of Staphylococcus aureus on the sheet was detected by the above-mentioned test method. Take a portion of TSB on the slide, and observed bacterial adhesion (>3×107cfu / ml); take a portion of the final PBS wash solution on the slide, no colony formation (<100 cfu / ml) was observed.

Embodiment 4

[0097] Composition of the invention

[0098] Vorite 3025 polyisocyanate prepolymer (2 g) (CasChem, Inc.) was mixed with methotrexate (0.25 g) in methyl ethyl ketone (35 g). The mixture was stirred vigorously overnight. Gas chromatographic analysis showed the disappearance of methamphetamine. Infrared analysis shows 2269cm -1 The isocyanate band disappears. Tetrahydrofuran (10 g), diacetone alcohol (30 g), N-methylpyrrolidinedione (10 g), polyvinylpyrrolidinedione (3 g; Kollidon 90 F), fluorinated alkyl alkoxy ester ( 0.1g; Flourad FC-171) and methyl ethyl ketone (14.65g), then the mixture was stirred evenly.

[0099]Apply the solution to a clean polyvinyl chloride (PVC) sheet with a cotton swab soaked in the solution. No adhesion of Staphylococcus aureus was found on the solution-coated sheets after the bacterial adhesion analysis. Take a portion of PBS washing solution on the slide, and no bacterial adhesion was found. No methexidine was found in the extracted medium. ...

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Abstract

The present invention relates to biostatic compositions, as well as coatings and methods for preparing biostatic articles using the same. The compositions contain a hydrophilic polymer possessing a functional group which covalently bonds to an amine, thiol, carboxyl, or hydroxyl active group of an antimicrobial agent. The functional group is capable of reacting with and covalently bonding to an antimicrobial agent without effectively reducing antimicrobial property of the antimicrobial agent below its capability of acting as a biostatic agent and without releasing the antimicrobial agent into a solution.

Description

Background of the invention [0001] 1. field of invention [0002] The invention relates to a biofunctional structure composite, and the preparation of biofunctional structural coating articles and its preparation method by using the composite. [0003] 2. current technology [0004] Numerous attempts have been made to concentrate antimicrobials, preservatives, or antibiotics onto biomaterial or drug surfaces to reduce the likelihood of bacterial adhesion and thus bacterial infection, and several approaches have been investigated, including (1 ) embedding the active compound in a surface coating containing a polymeric layer or matrix, (2) coupling the active ingredient to the surface polymer, or applying the coating by ionic or other electrostatic forces, and (3) incorporating the active ingredient Covalently or chemically bonded to the surface of a polymer or material. [0005] The first method involves mechanically embedding the active agent in a polymer matrix. Release...

Claims

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Application Information

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IPC IPC(8): A61L2/16A01N25/10A01N25/24A01N43/54A01N47/36A61L29/00C08G18/10C08G18/32C08L75/04C09D5/14C09D175/04C09D201/02
CPCA01N43/54C08G18/10A01N25/10A01N25/24A01N25/34A01N2300/00C08G18/285
Inventor 琼·M·答拉瑞沃托玛
Owner 海德罗默公司
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