Indomethacin liposome eye drops
A technology of indomethacin and eye drops, applied in liposome delivery, organic active ingredients, sensory diseases, etc., can solve the problems of indomethacin eye drops on the market and reduce burning and stinging sensations , excellent curative effect
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Embodiment 1
[0078] Prepare 1000 0.4ml eye drops whose prescription is:
[0079] Indomethacin 2g
[0080] Lipid 30g for liposome preparation
[0081] Borate buffer solution 400ml
[0082] Wherein the composition of borate buffer solution is as follows:
[0083] Boric acid 8.35g
[0084] Borax 1.2g
[0085] Add water for injection to 500ml
[0086] Preparation:
[0087] 1. Weigh the lipid and indomethacin for the preparation of liposomes in the prescription amount, dissolve them with ethanol, and mix them evenly.
[0088] 2 Put the lipid solution on a thin film evaporator, remove ethanol under reduced pressure, and prepare a lipid film.
[0089] 3 Prepare a borate buffer solution with a pH of 7.0 according to the prescription, filter and sterilize for later use.
[0090] 4 Pour the borate buffer solution into the phospholipid membrane, and after the phospholipid membrane is completely hydrated, extrude with a high-pressure homogenizer to prepare liposomes.
[0091] 5. Under aseptic...
Embodiment 2
[0093] Prepare 1000 0.2ml eye drops whose prescription is:
[0094] Indomethacin 2g
[0095] Lipid 30g for liposome preparation
[0096] Borate buffer solution 200ml
[0097] Wherein the composition of borate buffer solution is as follows:
[0098] Boric acid 8.35g
[0099] Borax 1.2g
[0100] Add water for injection to 500ml
[0101] Preparation:
[0102] 1. Weigh the lipid and indomethacin for the preparation of liposomes in the prescription amount, dissolve them with ethanol, and mix them evenly.
[0103] 2 Put the lipid solution on a thin film evaporator, remove ethanol under reduced pressure, and prepare a lipid film.
[0104] 3 Prepare a borate buffer solution with a pH of 7.0 according to the prescription, filter and sterilize for later use.
[0105] 4 Pour the borate buffer solution into the phospholipid membrane, and after the phospholipid membrane is completely hydrated, extrude with a high-pressure homogenizer to prepare liposomes.
[0106] 5. Under aseptic...
Embodiment 3
[0108] Lipid formulation for liposome preparation (100g)
[0109] Soy lecithin: cholesterol (molar ratio) = 8:2
[0110] Soy Lecithin 88.88g
[0111] Cholesterol 11.02g
[0112] Vitamin E 0.10g
[0113] A total of 100g was produced
[0114] Preparation:
[0115] Weigh the soybean lecithin, cholesterol and vitamin E of the prescribed amount, dissolve them with absolute ethanol, and mix them evenly.
[0116] Put the lipid solution on a thin-film evaporator, and remove absolute ethanol under reduced pressure to obtain a lipid block.
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