Indomethacin liposome eye drops

A technology of indomethacin and eye drops, applied in liposome delivery, organic active ingredients, sensory diseases, etc., can solve the problems of indomethacin eye drops on the market and reduce burning and stinging sensations , excellent curative effect

Inactive Publication Date: 2005-06-22
珠海丽波医药科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no indomethacin eye drops with liposome as carrier on the market

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Prepare 1000 0.4ml eye drops whose prescription is:

[0079] Indomethacin 2g

[0080] Lipid 30g for liposome preparation

[0081] Borate buffer solution 400ml

[0082] Wherein the composition of borate buffer solution is as follows:

[0083] Boric acid 8.35g

[0084] Borax 1.2g

[0085] Add water for injection to 500ml

[0086] Preparation:

[0087] 1. Weigh the lipid and indomethacin for the preparation of liposomes in the prescription amount, dissolve them with ethanol, and mix them evenly.

[0088] 2 Put the lipid solution on a thin film evaporator, remove ethanol under reduced pressure, and prepare a lipid film.

[0089] 3 Prepare a borate buffer solution with a pH of 7.0 according to the prescription, filter and sterilize for later use.

[0090] 4 Pour the borate buffer solution into the phospholipid membrane, and after the phospholipid membrane is completely hydrated, extrude with a high-pressure homogenizer to prepare liposomes.

[0091] 5. Under aseptic...

Embodiment 2

[0093] Prepare 1000 0.2ml eye drops whose prescription is:

[0094] Indomethacin 2g

[0095] Lipid 30g for liposome preparation

[0096] Borate buffer solution 200ml

[0097] Wherein the composition of borate buffer solution is as follows:

[0098] Boric acid 8.35g

[0099] Borax 1.2g

[0100] Add water for injection to 500ml

[0101] Preparation:

[0102] 1. Weigh the lipid and indomethacin for the preparation of liposomes in the prescription amount, dissolve them with ethanol, and mix them evenly.

[0103] 2 Put the lipid solution on a thin film evaporator, remove ethanol under reduced pressure, and prepare a lipid film.

[0104] 3 Prepare a borate buffer solution with a pH of 7.0 according to the prescription, filter and sterilize for later use.

[0105] 4 Pour the borate buffer solution into the phospholipid membrane, and after the phospholipid membrane is completely hydrated, extrude with a high-pressure homogenizer to prepare liposomes.

[0106] 5. Under aseptic...

Embodiment 3

[0108] Lipid formulation for liposome preparation (100g)

[0109] Soy lecithin: cholesterol (molar ratio) = 8:2

[0110] Soy Lecithin 88.88g

[0111] Cholesterol 11.02g

[0112] Vitamin E 0.10g

[0113] A total of 100g was produced

[0114] Preparation:

[0115] Weigh the soybean lecithin, cholesterol and vitamin E of the prescribed amount, dissolve them with absolute ethanol, and mix them evenly.

[0116] Put the lipid solution on a thin-film evaporator, and remove absolute ethanol under reduced pressure to obtain a lipid block.

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PUM

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Abstract

The invention relates to an ophthalmic pharmaceutical preparation, especially a liposome eye drop preparation containing indomethacin. The composition of the indomethacin liposome eye drop of the invention is: indomethacin, prepared lipid Body fat, buffer solution.

Description

Technical field: [0001] The invention relates to an ophthalmic pharmaceutical preparation, in particular to a liposome eye drop preparation containing indomethacin. Background technique: [0002] Indometacin, also known as indomethacin, is a commonly used non-steroidal anti-inflammatory drug in clinical practice and is the main metabolite of arachidonic acid. Inflammation stimulates the metabolism of arachidonic acid and releases its metabolites, which can lead to inflammatory reactions such as fever, pain, vasodilation, increased permeability, and leukocyte exudation. Indomethacin inhibits prostaglandin (PG) biosynthesis by inhibiting the metabolism of arachidonic acid. Therefore, it is clinically used as an antipyretic and analgesic for the treatment of acute and chronic rheumatoid arthritis, gouty arthritis and cancer pain. It can also be used for colic caused by biliary colic and urinary tract stones. Dysmenorrhea is also curative. Since this drug can inhibit the prot...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K31/405A61P27/02
Inventor 孙仁俊史雪燕
Owner 珠海丽波医药科技有限公司
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