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Compound lidocaine microneedle patch for easing pain

A technology of compound lidocaine and lidocaine hydrochloride, which is applied in the direction of tablet delivery, pharmaceutical formulations, and medical devices, to achieve the effects of improving stability, improving curative effect, and improving release and absorption in the body

Inactive Publication Date: 2022-08-09
THE EYE HOSPITAL OF WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] At present, the compound lidocaine / prilocaine microneedle patch with stable and controllable quality and good analgesic effect has not been reported yet.

Method used

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  • Compound lidocaine microneedle patch for easing pain
  • Compound lidocaine microneedle patch for easing pain
  • Compound lidocaine microneedle patch for easing pain

Examples

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preparation example Construction

[0024] The second aspect of the present invention provides the preparation method of the above-mentioned compound lidocaine / prilocaine microneedle patch, which comprises the following steps:

[0025] (1) lidocaine hydrochloride and prilocaine hydrochloride of the recipe quantity are added in an appropriate amount of water to be fully dissolved to obtain an aqueous drug solution;

[0026] (2) the host material of recipe quantity is added in the medicine aqueous solution that step (1) obtains, and stirring obtains homogeneous solution;

[0027] (3) inject the solution obtained in step (2) into a PDMS mold after swelling for 2-6 hours, centrifuge at low temperature, and dry;

[0028] (4) Pour the fully swollen backing material aqueous solution in the prescribed amount into the needle tip layer obtained in step (3), centrifuge at low temperature, dry, and demould, that is, it is obtained.

[0029] Preferably, the solution swelling time of the step (3) is 4 hours.

[0030] Prefer...

Embodiment 1

[0038] Embodiment 1 Compound lidocaine / prilocaine microneedle patch MN1 of the present invention

[0039] Weigh 0.015g lidocaine hydrochloride and 0.01g prilocaine hydrochloride, add 2.5mL purified water, and fully dissolve to obtain an aqueous drug solution; 0.19g hyaluronic acid (relative molecular mass 1*104-1*105), 0.19 g chondroitin sulfate and 0.095g PVP K30 were added to the above-mentioned drug aqueous solution in turn, and a homogeneous solution was obtained by stirring; after the above-mentioned solution was swollen for 4 hours, 60 μL was injected into the PDMS mold, and centrifuged at 4°C, 4000 r / min for 10 minutes to make the solution fully Fill the needle-shaped cavity of the mold; after centrifugation and drying at 25 °C for 1 hour, add 100 μL of the fully swollen 0.2 g / mL polyvinyl alcohol aqueous solution backing material, and centrifuge under the same conditions to remove the air bubbles in the backing solution. After drying at 25° C. for 12 hours, the mold is...

Embodiment 2

[0040] Embodiment 2 Compound lidocaine / prilocaine microneedle patch MN2 of the present invention

[0041] Adjust the ratio of matrix materials, and replace the composition of 0.19g hyaluronic acid, 0.19g chondroitin sulfate and 0.095g PVPK30 in Example 1 with the composition of 0.095g hyaluronic acid, 0.19g chondroitin sulfate and 0.19g PVP K30 , and the rest of the prescription and preparation process are the same as in Example 1, to obtain compound lidocaine / prilocaine microneedle patch MN2 of the present invention.

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Abstract

The invention discloses a compound lidocaine microneedle patch for analgesia, the microneedle patch comprises a needle tip layer and a backing layer, the needle tip layer is prepared from 1-5 parts by weight of lidocaine hydrochloride, 1-5 parts by weight of prilocaine hydrochloride and 90-98 parts by weight of a matrix material, the backing layer is prepared from 160-240 parts by weight of a backing material, and the backing layer is prepared from a matrix material. The matrix material is selected from one or more of hyaluronic acid, chondroitin sulfate and polyvinylpyrrolidone, the backing material is selected from one or more of hyaluronic acid, polyvinyl alcohol and glucan, and the traditional Chinese medicine composition has the advantages of being stable in quality, good in treatment effect and capable of achieving industrial production.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a compound lidocaine microneedle patch for analgesia. Background technique [0002] The chemical name of lidocaine is 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide, which has a strong anesthetic effect, twice that of procaine, and has strong penetrating power. It has a fast onset of action and is considered to be an ideal local anesthetic for various anesthesia and for the treatment of arrhythmias. [0003] Prilocaine is commonly used as anesthesia for various procedures including epidural, block, and infiltration. The drug has better efficacy than procaine, and the action intensity and speed are similar to lidocaine, but the action time is longer, the toxicity is smaller, and the accumulation is also smaller due to fast metabolism. [0004] As local anesthetics, lidocaine and prilocaine have been used in the treatment of various types of pain. Most of the dosage forms lis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K9/00A61K31/167A61K47/36A61K47/32A61P29/00A61P25/00A61M37/00
CPCA61K9/7023A61K9/0021A61K31/167A61K47/36A61K47/32A61P29/00A61P25/00A61M37/0015A61M2037/0053A61K2300/00
Inventor 李军花吴星马吉胜金利泰
Owner THE EYE HOSPITAL OF WENZHOU MEDICAL UNIV
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