Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of lysine in preparation of medicine for inhibiting or treating paraquat poisoning

A technology of lysine and Baicao, which is applied in the field of medicine, can solve problems not related to the effect of lysine, and achieve the effects of improving pulmonary fibrosis and mouse death, improving mouse weight, reducing diet and drinking water

Pending Publication Date: 2022-08-05
SHANGHAI FIRST PEOPLES HOSPITAL
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the above studies did not involve the role of lysine in the treatment of paraquat poisoning, and the function of lysine for detoxification of paraquat has not been reported so far

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of lysine in preparation of medicine for inhibiting or treating paraquat poisoning
  • Application of lysine in preparation of medicine for inhibiting or treating paraquat poisoning
  • Application of lysine in preparation of medicine for inhibiting or treating paraquat poisoning

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0033] The technical solutions of the present invention will be further described below with reference to the accompanying drawings and embodiments.

[0034] The term "paraquat" is a quick-acting contact-killing biocidal bipyridine herbicide. The active ingredient is extremely destructive to the chloroplast layer membrane, but has no effect on non-green tissues, so it has a good herbicidal effect.

[0035] The term "pulmonary fibrosis" refers to the end-stage changes of a large class of lung diseases characterized by the proliferation of fibroblasts and the accumulation of a large amount of extracellular matrix accompanied by inflammatory damage and tissue structure destruction. Abnormal repair results in structural abnormalities (scarring). Pulmonary fibrosis seriously affects the respiratory function of the human body, manifested as dry cough, progressive dyspnea (consciously insufficient air), and with the aggravation of the disease and lung damage, the patient's respirator...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses application of lysine to preparation of a medicine for inhibiting or treating paraquat poisoning. The lysine can obviously improve the reduction of the weight, diet and drinking water of the mouse caused by paraquat poisoning, improve the pulmonary fibrosis and death of the mouse after the mouse is poisoned, and can be used for treating the paraquat poisoning and relieving the progress of the in-vivo pulmonary fibrosis after the paraquat poisoning.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the use of lysine in the preparation of a medicine for inhibiting or treating pulmonary fibrosis caused by paraquat poisoning. Background technique [0002] Paraquat (PQ) is a widely used organic heterocyclic contact defoliant and herbicide. Because of its convenient access, the incidence of poisoning caused by mistaken or self-administration of PQ is high in clinical practice. The fatality rate of patients after poisoning is very high. PQ poisoning can cause damage to multiple organs such as lung, liver, kidney, brain, etc. The lung is its main target organ. After entering the body, 90% of it accumulates in the lung, rapidly destroying the lung parenchyma cells. In the early stage of poisoning, it can cause extensive pulmonary hemorrhage and Edema, leading to severe acute lung injury (ALI) or acute respiratory distress syndrome (ARDS), or even systemic multiple organ dysfunction (MODS),...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61P39/02A61P11/00
CPCA61K31/198A61P39/02A61P11/00Y02A50/30
Inventor 王瑞兰杨正峰杨雯雨朱勇孟潇潇马新润田锐
Owner SHANGHAI FIRST PEOPLES HOSPITAL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com