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Application of lysine in preparation of medicine for inhibiting or treating paraquat poisoning

A technology of lysine and Baicao, which is applied in the field of medicine, can solve problems not related to the effect of lysine, and achieve the effects of improving pulmonary fibrosis and mouse death, improving mouse weight, reducing diet and drinking water

Pending Publication Date: 2022-08-05
SHANGHAI FIRST PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, the above studies did not involve the role of lysine in the treatment of paraquat poisoning, and the function of lysine for detoxification of paraquat has not been reported so far

Method used

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  • Application of lysine in preparation of medicine for inhibiting or treating paraquat poisoning
  • Application of lysine in preparation of medicine for inhibiting or treating paraquat poisoning
  • Application of lysine in preparation of medicine for inhibiting or treating paraquat poisoning

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Embodiment Construction

[0033] The technical solutions of the present invention will be further described below with reference to the accompanying drawings and embodiments.

[0034] The term "paraquat" is a quick-acting contact-killing biocidal bipyridine herbicide. The active ingredient is extremely destructive to the chloroplast layer membrane, but has no effect on non-green tissues, so it has a good herbicidal effect.

[0035] The term "pulmonary fibrosis" refers to the end-stage changes of a large class of lung diseases characterized by the proliferation of fibroblasts and the accumulation of a large amount of extracellular matrix accompanied by inflammatory damage and tissue structure destruction. Abnormal repair results in structural abnormalities (scarring). Pulmonary fibrosis seriously affects the respiratory function of the human body, manifested as dry cough, progressive dyspnea (consciously insufficient air), and with the aggravation of the disease and lung damage, the patient's respirator...

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Abstract

The invention discloses application of lysine to preparation of a medicine for inhibiting or treating paraquat poisoning. The lysine can obviously improve the reduction of the weight, diet and drinking water of the mouse caused by paraquat poisoning, improve the pulmonary fibrosis and death of the mouse after the mouse is poisoned, and can be used for treating the paraquat poisoning and relieving the progress of the in-vivo pulmonary fibrosis after the paraquat poisoning.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the use of lysine in the preparation of a medicine for inhibiting or treating pulmonary fibrosis caused by paraquat poisoning. Background technique [0002] Paraquat (PQ) is a widely used organic heterocyclic contact defoliant and herbicide. Because of its convenient access, the incidence of poisoning caused by mistaken or self-administration of PQ is high in clinical practice. The fatality rate of patients after poisoning is very high. PQ poisoning can cause damage to multiple organs such as lung, liver, kidney, brain, etc. The lung is its main target organ. After entering the body, 90% of it accumulates in the lung, rapidly destroying the lung parenchyma cells. In the early stage of poisoning, it can cause extensive pulmonary hemorrhage and Edema, leading to severe acute lung injury (ALI) or acute respiratory distress syndrome (ARDS), or even systemic multiple organ dysfunction (MODS),...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61P39/02A61P11/00
CPCA61K31/198A61P39/02A61P11/00Y02A50/30
Inventor 王瑞兰杨正峰杨雯雨朱勇孟潇潇马新润田锐
Owner SHANGHAI FIRST PEOPLES HOSPITAL
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