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Prussian blue-like nano material as well as preparation method and application thereof

A Prussian blue-like, nanomaterial technology, applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve the problems of unsatisfactory treatment effect, small particle size of nanoparticles, large side effects, etc., and achieve excellent biological safety, high hydrophilicity and other problems. performance, low cost

Pending Publication Date: 2022-07-29
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Description
  • Claims
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Problems solved by technology

[0005] In order to solve the current Fe 2+ or Fe 3+ The therapeutic effect used in the treatment of many diseases caused by overdose is not satisfactory, the side effects are large and the shortcomings of poor safety. The purpose of the present invention is to provide a kind of nanomaterial (nanomedicine) that can treat this type of disease. Its preparation method is simple, nanoparticle Good dispersion, small particle size, high biological safety

Method used

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  • Prussian blue-like nano material as well as preparation method and application thereof
  • Prussian blue-like nano material as well as preparation method and application thereof
  • Prussian blue-like nano material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] 88.8 mg of calcium chloride (0.8 mmol) and 300 mg of polyvinylpyrrolidone PVP with a molecular weight of 10,000 were dissolved in 120 mL of a deionized aqueous solution of pH=1 (pH was adjusted by hydrochloric acid) to obtain a calcium chloride solution; 263.4 mg of Potassium ferricyanide (0.8 mmol) was dissolved in 40 mL of a deionized aqueous solution adjusted with pH=1 hydrochloric acid to obtain a potassium ferricyanide solution. Then, it was rapidly added dropwise to the calcium chloride solution at a rate of 200 mL / h and reacted at room temperature (30° C.) for 1 hour. After the end of the reaction, it was subjected to dialysis treatment for 12 hours. Finally, it is collected in a centrifuge tube and vacuum-dried to obtain a Prussian blue-like nanomaterial. The chemical formula of the obtained Prussian blue-like nanomaterial CaPB is KCa[Fe(CN) 6 ], and the average particle size is 36 nm.

[0048] Fe 2+ Binding test: 500 μL of Prussian blue-like nanomaterial so...

Embodiment 2

[0051] The preparation process of the Prussian blue-like nanomaterial in Example 2 refers to Example 1, with the difference that magnesium chloride replaces calcium chloride, and the amount of the substance remains unchanged at 0.8 mmol, that is, 162.64 mg of magnesium chloride hexahydrate. The mass of polyvinylpyrrolidone PVP with a molecular weight of 10,000 remains unchanged at 300 mg. Other conditions remain unchanged. The chemical formula of the obtained Prussian blue-like nanomaterial MgPB is KMg[Fe(CN) 6 ] with an average particle size of 30 nm.

[0052] Cell experiments:

[0053] H9C2 cardiomyocytes were first incubated with different concentrations of DOX for 6 hours to detect the cytotoxicity. Then taking 20 μg / mL DOX as an example, H9C2 cells were first incubated with DOX for 6 hours, and then given different doses of MgPB (10, 20, 40 and 80 μg / mL) or DEX (12.5, 25 and 50 μg / mL) drugs After 6 hours of treatment, cell viability was measured. from Image 6 It ca...

Embodiment 3

[0058] The preparation process of the Prussian blue-like nanomaterial in Example 3 refers to Example 1, with the difference that zinc chloride replaces calcium chloride, and the amount of the substance is 0.5 mmol, that is, 103 mg. and 300 mg of polyvinylpyrrolidone PVP with a molecular weight of 10,000 were dissolved in 60 mL of deionized aqueous solution of pH=1 (pH was adjusted by hydrochloric acid) to obtain a zinc chloride solution; other conditions remained unchanged. The resulting Prussian blue-like nanomaterials are presented as ZnPB nanoparticles with an average particle size of 8 nm, and the chemical formula is Zn 3 [Fe(CN) 6 ] 2 , and formed uniform nanoclusters with a particle size of about 28 nm.

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Abstract

The invention relates to a Prussian blue-like nano material and a preparation method and application thereof, the chemical formula of the Prussian blue-like nano material is KxAy [Fe (CN) 6] z, A is selected from at least one of calcium, magnesium, zinc, manganese and iron, 0 < = x < = 1, 1 < = y < = 3, and 1 < = z < = 2.

Description

technical field [0001] The present invention relates to a high-efficiency free Fe-based product with high biocompatibility, water solubility and in vivo safety 2+ Chemically conjugated treatment of Fe in vivo 2+ or Fe 3+ Diseases caused by excess, including but not limited to diseases such as heart damage induced by tumor chemotherapy, are Prussian blue-like nanomaterials and a preparation method thereof, belonging to the field of biomedicine. Background technique [0002] Fe in different parts of the body 2+ or Fe 3+ A significant increase in the content of serotonin can trigger various cell death modes such as ferroptosis, apoptosis, and autophagy in tissue cells, thereby causing various types of diseases, including myocardial damage. At present, such disease models basically use physical complexation to reduce Fe in vivo 2+ Therefore, there are problems such as insufficient complexation efficiency, unsatisfactory treatment effect or large side effects, and the resear...

Claims

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Application Information

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IPC IPC(8): A61K33/30A61K33/26A61K9/08A61P9/04B82Y5/00C01C3/08C01C3/12
CPCA61K33/30A61K33/26A61K9/08A61K9/0019A61P9/04B82Y5/00C01C3/08C01C3/12
Inventor 霍敏锋施剑林
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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