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Application of ferrous ions in preparation of product for treating bacterial infection

A ferrous ion and bacterial infection technology, applied in the field of medicine, can solve the problems of inability to effectively prevent bacterial migration, colonization, inability to completely remove bacteria, and other tissue and organ lesions, so as to reduce the risk of MRSA infection and treat epidermis and eye infection, the effect of strong material adaptability

Active Publication Date: 2022-07-29
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing studies have shown that although antibiotics have high bactericidal efficacy and low-dose bactericidal effect, they cannot achieve the possibility of completely eradicating bacteria. However, the large-scale use of these antibiotic-containing eye drops and ointments will increase the risk of bacterial resistance , and make the human body drug dependent on it, forcing the increase of drug dosage, resulting in a vicious circle. When the human body is repeatedly infected with bacteria, the human body's resistance to this antibiotic ointment will make the antibiotics ineffective on the human body. Moreover, such The treatment cannot effectively prevent the migration and colonization of bacteria in the body, and it is easy to cause lesions in other tissues and organs

Method used

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  • Application of ferrous ions in preparation of product for treating bacterial infection
  • Application of ferrous ions in preparation of product for treating bacterial infection
  • Application of ferrous ions in preparation of product for treating bacterial infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A preparation method of hydrogel, comprising the following steps:

[0034] S1. Dissolve ferrous sulfate and ascorbic acid in sterile ultrapure water to prepare a mixed solution, which is heated to 50° C. The concentration of ferrous sulfate in the mixed solution is 1 μmol / L, and the concentration ratio of ascorbic acid to ferrous sulfate is 1 :1;

[0035] S2, adding hyaluronic acid powder during the heating process, stirring until the hyaluronic acid powder is dissolved to form a stable colloid to obtain the hydrogel, and the amount of hyaluronic acid added is 2% of the mass of the mixed solution.

[0036] Hydrogels prepared by the above method.

[0037] The application of the hydrogel for treating bacterial keratitis.

Embodiment 2

[0039] A preparation method of hydrogel, comprising the following steps:

[0040] S1. Dissolve ferrous sulfate and ascorbic acid in sterile ultrapure water to prepare a mixed solution, which is heated to 50° C. The concentration of ferrous sulfate in the mixed solution is 1 μmol / L, and the concentration ratio of ascorbic acid to ferrous sulfate is 1 :1;

[0041] S2, adding sodium alginate powder during the heating process, stirring until the sodium alginate powder is dissolved to form a stable colloid to obtain the hydrogel, and the addition amount of sodium alginate is 2% of the mass of the mixed solution.

[0042] Hydrogels prepared by the above method.

[0043] The application of the hydrogel for treating skin wound infection.

Embodiment 3

[0045] The difference between Example 3 and Example 1 is that the ferrous compound is ferrous chloride.

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Abstract

The invention discloses application of ferrous ions in preparation of a product for treating bacterial infection, and belongs to the technical field of medicines.The ferrous ions are used for an antibacterial activity test of staphylococcus aureus and show a strong bactericidal effect, the survival rate of the ferrous ions is smaller than 0.001% when the ferrous ions are used for sterilizing the staphylococcus aureus, and the survival rate of the ferrous ions is smaller than 0.001% when the ferrous ions are used for sterilizing methicillin-resistant staphylococcus aureus (MRSA) when the ferrous ions are used for sterilizing the methicillin-resistant staphylococcus aureus (MRSA). The survival rate of the ferrous ion-containing hydrogel is less than 0.01%, the ferrous ion-containing hydrogel is used for treating keratitis and skin wound infection, the risk of MRSA infection of the lung can be remarkably reduced, breeding and spreading of microorganisms in the body can be timely and effectively prevented, and it is revealed that the medicine containing the ferrous compound can be used for treating infection of staphylococcus aureus including MRSA.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of ferrous ions in the preparation of products for treating bacterial infections. Background technique [0002] Keratitis is one of the common diseases in ophthalmology and one of the main blinding diseases in my country. Bacteria, fungi, viruses and other infections are one of the most direct factors that cause keratitis. When the corneal epithelium is damaged, infectious inflammation is very likely to occur. It is very likely to induce the occurrence of infectious keratitis. It is worth noting that according to the relevant investigations of the current clinical authority, the clinically high incidence rate is still bacterial infectious keratitis caused by Staphylococcus aureus and Pseudomonas aeruginosa, and the incidence trend is increasing year by year. Prevention of keratitis requires attention. [0003] Staphylococcus aureus is the main culprit of commo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/26A61K9/06A61K47/36A61K47/22A61P31/04A61P27/02A61P17/02
CPCA61K33/26A61P31/04A61P27/02A61P17/02A61K9/06A61K47/22A61K47/36Y02A50/30A61K31/375A61K31/728A61K9/0014A61K47/02
Inventor 胡梁斌莫海珍周晓辉李红波徐丹刘振彬王贞
Owner SHAANXI UNIV OF SCI & TECH
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