Biomarker suitable for early discovery, early prediction or early diagnosis of severe chronic obstructive pulmonary disease as well as application and screening method thereof

Abstract

The invention discloses a biomarker suitable for early discovery, early prediction or early diagnosis of severe chronic obstructive pulmonary disease (chronic obstructive pulmonary disease for short), and the biomarker is a protein population biomarker, a metabolite population biomarker or a proteome-metabolome combined population biomarker. The invention also discloses application of the biomarker in preparation of a product for early discovery, early prediction or early diagnosis of severe chronic obstructive pulmonary disease risk, and a screening method of the biomarker. The biomarker changes the traditional thought of single marker detection, uses a group of protein group biomarkers, metabolite group biomarkers or proteome-metabolome combined group biomarkers as pattern markers to diagnose severe chronic obstructive pulmonary disease, and has unique advantages.

Description

technical field [0001] The invention belongs to the technical field of proteome-metabolomics, and in particular relates to a biomarker suitable for early detection, early prediction or early diagnosis of severe chronic obstructive pulmonary disease and its application and screening method. Background technique [0002] Chronic Obstructive Pulmonary Disease (COPD, chronic obstructive pulmonary disease) is an important chronic respiratory disease that seriously endangers human health. The study estimated that the global prevalence of COPD in 2017 was 3.92% (95% CI 3.52%-4.32%), and the mortality rate due to COPD was estimated to be 42 / 100,000 (4.72% of all-cause deaths), estimated The disability-adjusted life-years (DALYs) rate was 1068.02 / 100,000 (Global Burden of Disease Study 2017). In 2020, COPD has become the third leading cause of death in the world, and one of the main causes of increased morbidity and mortality worldwide, resulting in severe economic and social burden...

AI Technical Summary

Problems solved by technology

In 2020, COPD has become the third leading cause of death in the world, and it is one of the main reasons for the increase in disability and mortality worldwide, resulting in serious economic and social burdens, and this situation is getting worse day by day, but the severity is slow Early detection and early treatment of obstructive pulmonary disease still face serious challenges

Research on proteomics in the diagnosis of COPD, mechanism exploration, syndrome diagnosis and drug effect mechanism has been carried out, but it is still in its infancy, and there are problems such as high price and insufficient repeatability verification

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