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Preparation method of double-layer microneedle patch for atopic dermatitis

A technology for atopic dermatitis and microneedle patches, applied in the field of biomedical materials, can solve the problems of poor treatment effect, microneedle patches without atopic dermatitis, and insufficient mechanical properties of microneedle patches, which are not easy to achieve Immune rejection, relief of symptoms of atopic dermatitis, strong biocompatibility

Pending Publication Date: 2022-07-08
THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although the above prior art has researched and developed some microneedle patches, there are still some problems in the prior art. Insufficient to successfully penetrate the thickened skin of atopic dermatitis patients deep into the epidermis, resulting in ineffective treatment

Method used

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  • Preparation method of double-layer microneedle patch for atopic dermatitis
  • Preparation method of double-layer microneedle patch for atopic dermatitis
  • Preparation method of double-layer microneedle patch for atopic dermatitis

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preparation example Construction

[0032] The invention provides a preparation method of a double-layer microneedle patch for atopic dermatitis, comprising the following steps:

[0033] 1) Preparation of inner layer microneedles: Fill the microneedle tip inner layer raw material solution containing the therapeutic drug into a small template with needle-like holes, after the microneedle tip inner layer raw material solution is solidified, fill the microneedle backing layer raw material solution into the template, and demould after drying to obtain the inner layer microneedle patch;

[0034] 2) Preparation of double-layer microneedles: Fill the microneedle tip outer layer raw material solution into a large template with needle-shaped holes, scrape off the excess solution, press the inner layer microneedle patch into the large template, and dry it. After demoulding, a double-layer microneedle patch was prepared.

[0035] The microneedle tip inner layer raw material solution is selected from one or more of methacr...

Embodiment 1

[0049] A double-layer microneedle patch based on methacrylate gelatin and sodium hyaluronate, prepared according to the following method:

[0050] (1) Preparation of raw material solution for the inner layer of the microneedle tip

[0051] Microneedle tip inner layer raw material solution: prepare gelatin methacrylate with a mass fraction of 30% containing the therapeutic drug (triamcinolone acetonide, concentration of 20 mg / mL) as the microneedle tip inner layer raw material solution, and apply it to the inner layer of the microneedle tip. Add 2-hydroxy-2-methylpropiophenone with a volume fraction of 1% to the raw material solution to form a microneedle raw material solution to be cured and place it in the dark. The raw material solution of the inner layer of the microneedle tip is cured.

[0052] (2) Prepare the raw material solution of the microneedle backing layer and the raw material solution of the outer layer of the microneedle tip

[0053] Microneedle tip outer layer...

Embodiment 2

[0059] A double-layer microneedle patch based on polyethylene glycol diacrylate and polyvinylpyrrolidone, prepared according to the following method:

[0060] (1) Preparation of raw material solution for the inner layer of the microneedle tip

[0061] Microneedle tip inner layer raw material solution: prepare a polyethylene glycol diacrylate with a mass fraction of 20% containing a therapeutic drug (dexamethasone, concentration of 20mg / mL) as a microneedle tip inner layer raw material solution, and apply it to the microneedle tip. 2-hydroxy-2-methylpropiophenone with a volume fraction of 1% is added to the inner layer raw material solution to form a microneedle raw material solution to be cured and placed in the dark. The inner layer raw material solution of the microneedle tip to be cured is irradiated with ultraviolet light Polymerization means that the inner layer of the microneedle tip is solidified from the raw material solution.

[0062] (2) Prepare the raw material sol...

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Abstract

The invention discloses a preparation method of a double-layer microneedle patch for atopic dermatitis, which comprises the following steps: preparing a double-layer microneedle through double-template duplication; the preparation method comprises the following steps: forming a needle tip inner layer by adopting methacrylate gelatin through ultraviolet curing, then transferring a formed microneedle into a large template, and forming a needle tip outer layer by adopting sodium hyaluronate through drying, thereby preparing the double-layer microneedle patch. The prepared double-layer microneedle patch has excellent mechanical performance and can be successfully inserted into thickened skin of an atopic dermatitis patient, after the double-layer microneedle patch is inserted into the skin, the needle tip and the backing layer are rapidly separated, the outer-layer needle tip is rapidly dissolved under the action of tissue fluid, and the left inner-layer needle tip is high in biocompatibility and can slowly release treatment medicine; the traditional Chinese medicine composition is capable of resisting inflammation and repairing epidermal barrier, so that atopic dermatitis symptoms are relieved, and the traditional Chinese medicine composition is diversified in function, remarkable in curative effect and wide in application range.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a double-layer microneedle patch for atopic dermatitis and a preparation method thereof. Background technique [0002] Atopic dermatitis is a common recurring chronic inflammatory skin disease characterized by dry skin, pruritus, eczematous plaques, epidermal barrier defects, and immune hyperresponsiveness to allergens that affect individuals and their families. have a significant impact on quality of life and pose a major threat to patients and the economy. At present, atopic dermatitis is mainly treated clinically by topical or injection drugs. However, direct topical application on the skin has disadvantages such as multiple smears, low utilization rate, and poor compliance. The injection treatment method will inevitably lead to pain. Serious consequences such as blood vessel rupture and injection site necrosis may even occur. [0003] Microneedles have been sho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00A61K9/00A61K31/573A61K31/58A61K47/14A61K47/32A61K47/36A61K47/42A61P17/00A61P29/00
CPCA61M37/0015A61K9/0021A61K47/42A61K47/36A61K47/14A61K47/32A61K31/58A61K31/573A61P17/00A61P29/00A61M2037/0053
Inventor 施可庆宋丽婉肖健池俊杰张宏宇陈露露
Owner THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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