High-yield cyclic acid synthesis method

A synthesis method and a high-yield technology, applied in the field of high-yield cyclic acid synthesis, can solve the problems of long reaction time, poor hydrogenation effect, lack of catalytic hydrogenation structure, etc., and achieve the effect of increasing contact effect and improving catalytic hydrogenation effect. Effect

Pending Publication Date: 2022-06-28
江西照阳科技有限公司
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Problems solved by technology

[0004] During the production and processing of tranexamic acid, the semi-finished product needs to be catalytically hydrogenated to obtain the desired hydrogenated product. Usually, this process is carried out in a reactor. However, due to the lack of a special catalytic hydrogenation structure in the current reactor, after adding hydrogen The reaction time is long and the hydrogenation effect is not good

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Embodiment Construction

[0037]The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, but not all of the embodiments.

[0038] A high-yield cyclic acid synthesis method, comprising the following steps:

[0039] Step 1: Mix aminotoluic acid and pure water in a weight ratio of 1:5, slowly add concentrated sulfuric acid under stirring conditions, heat to a preset temperature, dissolve aminotoluic acid, crystallize by cooling, and filter to obtain pretreated aminotoluic acid , then add 5-7% mass fraction of sulfuric acid solution, platinum-based catalyst and pretreated aminotoluic acid from the feed port 25 of the synthesis mechanism into the reactor body 1 according to the weight ratio of 2:1:6, and close the The feed port 25 of the reactor body 1, the startup d...

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Abstract

The invention belongs to the technical field of cyclic acid synthesis, particularly relates to a high-yield cyclic acid synthesis method, and aims to solve the problems that an existing reaction kettle lacks a special catalytic hydrogenation structure, the reaction time is long after hydrogen is added, and the hydrogenation effect is poor. Adding a sulfuric acid solution with the mass fraction of 5-7%, a platinum catalyst and the pretreated aminomethylbenzoic acid into a reaction kettle body from a feeding hole of a synthesis mechanism according to the weight ratio of 2: 1: 6, closing the feeding hole of the reaction kettle body, and starting a device; after the heating plate is electrified, the electrical bar heats a solution in the reaction kettle body, after the temperature of the reaction solution reaches a preset temperature, the motor drives the shaft rod to rotate, and the stirring assembly mixes and stirs the reaction solution.

Description

technical field [0001] The invention relates to the technical field of cyclic acid synthesis, in particular to a high-yield cyclic acid synthesis method. Background technique [0002] Tranexamic acid, also known as tranexamic acid, tranexamic acid, hemostatic acid, molecular formula is C8H15NO2, chemical name is trans-4-aminomethylcyclohexanecarboxylic acid, it is a white crystalline powder, odorless, slight taste, in Soluble in water, almost insoluble in ethanol, acetone, chloroform or ether. [0003] Tranexamic acid has a wide range of effects in medicine and pharmacy. It can safely and reliably reduce the mortality of traumatic hemorrhage patients; it can reduce the possibility of progressive bleeding in craniocerebral patients; it can significantly reduce blood loss in women with excessive menstrual bleeding It can significantly reduce the amount of postpartum hemorrhage; it can reduce the risk of postoperative blood transfusion and reduce the amount of intraoperative a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C227/16C07C229/46C07C227/42C07C229/38B01J19/18
CPCC07C227/16C07C227/42B01J19/18B01J19/0053B01J19/0066C07C2601/14C07C229/38C07C229/46
Inventor 刘为祥李兴君章志成
Owner 江西照阳科技有限公司
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