Stent with modification layer, preparation method thereof and implantation instrument

A modified layer, super-hydrophilic technology, applied in the field of medical devices, can solve problems such as poor anticoagulation effect, and achieve the effect of prolonging the effective action time, improving the firmness, and improving the anticoagulant effect.

Pending Publication Date: 2022-06-28
成都百瑞恒通医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the dense mesh stents in the prior art at least have the problem of poor anticoagulant effect

Method used

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  • Stent with modification layer, preparation method thereof and implantation instrument
  • Stent with modification layer, preparation method thereof and implantation instrument
  • Stent with modification layer, preparation method thereof and implantation instrument

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preparation example Construction

[0040] The inventors have proposed through research that: in the prior art, the coating obtained by the chemical grafting method in the immersion method has poor firmness between the stent and the stent, which is easy to fall off and peel off, which leads to the anticoagulation time of the modified stent. Shorter, can not achieve good anticoagulant effect. Based on this, the present application proposes a method for preparing a scaffold with a modified layer, comprising the following steps:

[0041] The superhydrophilic monomer is sprayed and adsorbed onto the support substrate attached with the transition stage reactant while being ionized, and dried for the first time to obtain the first product of the support with a modified layer;

[0042] Mix the first product of the stent with the reactant solution of the transition section and carry out the second grafting, and then add the superhydrophilic monomer solution to the mixed system of the first product of the stent and the r...

Embodiment 1

[0079] The present embodiment provides a scaffold with a modified layer, and its preparation method is as follows:

[0080] ①Weigh 0.5g of arginine and add it to 25g of ethanol aqueous solution (containing 10g of ethanol), and after dissolving, obtain the first transition stage reactant solution; immerse the 304 stainless steel stent matrix completely in the first transition stage reactant solution, After soaking for 10 min, the wetted 304 stainless steel stent matrix was taken out and clamped on a charged jig.

[0081] ②Weigh 0.5g of phosphorylcholine, add it to 100g of formamide (second solvent), and dissolve to obtain the first superhydrophilic monomer solution; add the first superhydrophilic monomer solution to the ultrasonic charged particle spraying in atomizing equipment.

[0082] ③Turn on the ultrasonic charged particle spraying and atomizing equipment, and spray and adsorb the superhydrophilic monomer onto the electrically wetted stent substrate while ionizing in the...

Embodiment 2

[0089] The present embodiment provides a scaffold with a modified layer, and its preparation method is as follows:

[0090] ①Weigh 1g of aminopropyltriethoxysilane and add it to 50g of propanol, dissolve it to obtain the first transition stage reactant solution; completely soak the cobalt-chromium stent matrix in the first transition stage reactant solution, soak it in the first transition stage reactant solution. After 5 min, the wetted cobalt-chromium stent matrix was taken out and clamped on a charged jig.

[0091] 2. Weigh 2g of alginic acid and 0.5g of phosphorylcholine, add them to 100g of formamide (second solvent), and dissolve to obtain the first superhydrophilic monomer solution; add the first superhydrophilic monomer solution to the into the ultrasonic charged particle spray atomization equipment.

[0092] ③Turn on the ultrasonic charged particle spraying and atomizing equipment, and spray and adsorb the superhydrophilic monomer onto the electrically wetted stent s...

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Abstract

The invention discloses a stent with a modification layer, a preparation method of the stent and an implantation instrument, and belongs to the technical field of medical instruments. The preparation method comprises the following steps: spraying and adsorbing a super-hydrophilic monomer to a stent matrix attached with a transition section reactant while ionizing, and drying for the first time to obtain a primary stent product with a modification layer; and mixing the primary scaffold product with the transition section reactant solution, carrying out secondary grafting, adding the super-hydrophilic monomer solution into a mixed system of the primary scaffold product and the transition section reactant solution in a dropwise adding manner, carrying out a reaction, and carrying out secondary drying to obtain the scaffold with the modification layer. Compared with an existing blood flow guiding device chemical grafting process, the preparation method has the advantages that through adsorption of atomic bond energy after electrolysis, the firmness of the coating is greatly improved, and meanwhile, the hydrophilicity and biocompatibility of the product are effectively improved. The prepared stent product has good hydrophilicity, biocompatibility, anticoagulant activity and coating firmness, and has wide application prospects in implantable instruments.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular, to a stent with a modified layer, a preparation method thereof, and an implantation device. Background technique [0002] At present, neurointerventional methods are usually used to implant dense mesh stents for aneurysm treatment (especially the treatment of cerebral aneurysms). Using hemodynamic principles, dense mesh stents can significantly reduce the blood flow rate and flow into the aneurysm. A thrombus is formed in the aneurysm, and then the thrombus is eliminated through blood metabolism to remodel the blood vessels in the lesion. It has many advantages such as high safety, wide range of indications, and convenient operation. However, after the dense mesh stent is implanted into the arterial blood vessel as a foreign body, it will cause an immune response in the body's related tissues. The most unfavorable treatment for aneurysm is the acute coagulation reaction, wh...

Claims

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Application Information

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IPC IPC(8): A61B17/12
CPCA61B17/12177A61B17/12195A61B17/12113A61B2017/1205
Inventor 高飞万国江何俊淅王文渊
Owner 成都百瑞恒通医疗科技有限公司
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