Pharmaceutical composition for removing acnes and preparation method thereof

A composition and medicine technology, applied in the field of skin care, can solve the problems of low patient acceptance, increased skin light sensitivity, long treatment time, etc., and achieve the effects of simple and convenient preparation method, inhibiting pain and itching, and highlighting the treatment effect.

Pending Publication Date: 2022-06-24
李红梦
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Topical drugs include tretinoin, benzoyl peroxide, vitamins, etc. Although these topical drugs are the first-line drugs or even the first choice for acne treatment, they often cause local redness, desquamation, tightness, and burning sensation, etc. Skin irritation problems, and the consequences of cross-resistance, increased skin photosensitivity, pigmentation, and mild atrophy of the skin at the medication site are prone to occur, which limits its clinical application
In addition, although chemical therapy such as fruit acid and photodynamic therapy (PDT) are non-toxic, odorless, and highly permeable, they are costly and energy-intensive, and there may still be local facial problems such as erythema after treatment
Oral Chinese medicine may cause liver toxicity. Due to the processing, decoction and frequency of medication, there are problems such as long treatment time, and the acceptance of patients is generally not high.

Method used

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  • Pharmaceutical composition for removing acnes and preparation method thereof
  • Pharmaceutical composition for removing acnes and preparation method thereof
  • Pharmaceutical composition for removing acnes and preparation method thereof

Examples

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preparation example Construction

[0025] The application also provides a preparation method of a medicinal composition for removing acne, comprising the following steps:

[0026] After mixing amoxicillin, morpholineguanidine, ketoconazole, clobetasol propionate, lincomycin and lidocaine, place in a non-metallic mortar, grind to obtain a mixture, and store it in the dark;

[0027] The adjuvant and the transdermal agent are mixed with the mixture, water is added and stirred, and the finished pharmaceutical composition is obtained after heating and stirring evenly.

[0028] The preparation method of the present application is simple and convenient, and can prepare the pharmaceutical composition in batches.

[0029] In some embodiments of the present application, the above-mentioned grinding time is 3-8 min. After sufficient crushing, it can facilitate the uniform distribution of the medicine.

[0030] In some embodiments of the present application, the above heating is specifically heating at 60-80° C. for 30-5...

Embodiment 1

[0033] A preparation method of a medicinal composition for removing acne, comprising the following steps:

[0034] Raw materials: amoxicillin 3g, morpholineguanidine 2g, ketoconazole 50mg, clobetasol propionate 5mg, lincomycin 90mg, lidocaine 50mg and transdermal agent (mint oil) 500mg.

[0035] After mixing amoxicillin, morpholineguanidine, ketoconazole, clobetasol propionate, lincomycin and lidocaine, place them in a non-metallic mortar and grind for 3 minutes to obtain a mixture, which is protected from light;

[0036] The transdermal agent (mint oil) was mixed with the mixture, water was added and stirred, heated at 60° C. for 30 min, and after stirring evenly, the finished pharmaceutical composition was obtained.

Embodiment 2

[0038] A preparation method of a medicinal composition for removing acne, comprising the following steps:

[0039]Raw materials: amoxicillin 4g, morpholine guanidine 2.5g, ketoconazole 60mg, clobetasol propionate 2.5mg, lincomycin 65mg, lidocaine 50mg, transdermal agent (clove oil) 400mg and excipients (glycerol ) 10g.

[0040] After mixing amoxicillin, morpholineguanidine, ketoconazole, clobetasol propionate, lincomycin and lidocaine, place in a non-metallic mortar and grind for 3 minutes to obtain a mixture, which is stored in the dark;

[0041] The adjuvant (glycerol) and the transdermal agent (clove oil) are mixed with the mixture, water is added and stirred, heated at 60° C. for 30 minutes, and after stirring uniformly, the finished pharmaceutical composition is obtained.

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PUM

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Abstract

The invention provides a pharmaceutical composition for removing acnes and a preparation method thereof, and relates to the technical field of skin care. The pharmaceutical composition for removing acnes is prepared from the following raw materials: amoxicillin, moroxydine, ketoconazole, clobetasol propionate, lincomycin, lidocaine and a transdermal agent. The pharmaceutical composition provided by the invention has an outstanding treatment effect on acne, can effectively treat various bacterial skin infections such as impetigo, furuncle, folliculitis, acne vulgaris and acne vulgaris, and under the combined action of various medicines such as amoxicillin, moroxydine, ketoconazole, clobetasol propionate, lincomycin, lidocaine and a transdermal agent, the pharmaceutical composition can be used for treating various bacterial skin infections. The prominent treatment effect on the acne can be achieved.

Description

technical field [0001] The present application relates to the technical field of skin care, in particular, to a medicinal composition for removing acne and a preparation method thereof. Background technique [0002] Acne, also known as pimples, facial acne is the appearance of pimples on the face, which is a common skin disease, generally more common in teenagers. Acne is a chronic inflammatory skin disease of the pilosebaceous unit, which occurs on the face and upper body, forming polymorphic skin lesions such as blackheads, papules, pustules, and nodules. The disease often occurs in adolescence and is one of the most common diseases affecting more than 80-85% of the world's population. The high incidence of acne has resulted in the long-term and widespread use of antibiotics, resulting in increased bacterial resistance, bringing social consequences economic burden. [0003] Common symptoms are inflammatory papules, pustules, nodules, etc. Acne is one of the common skin ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7056A61K47/44A61P17/10A61P31/02A61P17/00A61K31/43A61K31/5375A61K31/496A61K31/573A61K31/167
CPCA61K31/43A61K31/5375A61K31/496A61K31/573A61K31/7056A61K31/167A61K9/0014A61K47/44A61P17/10A61P31/02A61P17/00A61K2300/00
Inventor 李红梦
Owner 李红梦
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