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Tablet containing coenzyme Q10 and preparation method thereof

A coenzyme and tablet technology, applied in the field of coenzyme Q10-containing tablets and its preparation, can solve the problems of low hardness, low hardness, poor compressibility, etc., reduce the content of related substances, solve the problem of poor content uniformity, enhance wear resistance and The effect of the ability to resist vibration

Active Publication Date: 2022-06-03
山东正牧生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] To overcome the deficiencies in the prior art, the present invention optimizes the auxiliary materials and dosage in the tablet core, adopts dry granulation, improves the sieving and mixing process in the prescription preparation method, optimizes the coating process, and solves problems such as poor compressibility and low hardness. problems, improve content uniformity, reduce the content of related substances, and improve long-term stability

Method used

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  • Tablet containing coenzyme Q10 and preparation method thereof
  • Tablet containing coenzyme Q10 and preparation method thereof
  • Tablet containing coenzyme Q10 and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: a kind of coenzyme Q10 tablet, its components and preparation process are as follows:

[0034] Chip composition, calculated in 1000 pieces

[0035]

[0036]

[0037] Preparation Process:

[0038] (1) pulverizing and sieving: pulverize coenzyme Q10, microcrystalline cellulose, povidone K30, magnesium stearate, and lutein in the recipe quantities, respectively, pass coenzyme Q10 and lutein through a 65-mesh sieve, and the microcrystalline Cellulose, povidone K30, and magnesium stearate were respectively passed through a 24-mesh sieve;

[0039] (2) mixing; the coenzyme Q10 and lutein sieved in step (1) were placed in a mixer and mixed for 5min, added microcrystalline cellulose, povidone K30, magnesium stearate and continued to mix for 10min, and then added Beeswax mixed for 10min;

[0040] (3) Granulation: use a dry granulator for granulation;

[0041] (4) drying and tableting;

[0042] (5) Coating: prepare a coating aqueous solution containing 4% ...

Embodiment 2

[0043] Embodiment 2: a kind of coenzyme Q10 tablet, its components and preparation process are as follows:

[0044] Chip composition, calculated in 1000 pieces

[0045] Element Weight (g) Coenzyme Q10 5 microcrystalline cellulose 220 Povidone K30 30 Magnesium stearate 15 beeswax 10 Lutein 1

[0046] Preparation Process:

[0047] (1) pulverizing and sieving: pulverize coenzyme Q10, microcrystalline cellulose, povidone K30, magnesium stearate, and lutein in the recipe quantities, respectively, pass coenzyme Q10 and lutein through a 65-mesh sieve, and the microcrystalline Cellulose, povidone K30, and magnesium stearate were respectively passed through a 24-mesh sieve;

[0048] (2) mixing; the coenzyme Q10 and lutein sieved in step (1) were placed in a mixer and mixed for 5min, added microcrystalline cellulose, povidone K30, magnesium stearate and continued to mix for 10min, and then added Beeswax mixed for 10min;

[0049] (3)...

Embodiment 3

[0052] Embodiment 3: a kind of coenzyme Q10 tablet, its components and preparation process are as follows:

[0053] Chip composition, calculated in 1000 pieces

[0054] Element Weight (g) Coenzyme Q10 15 microcrystalline cellulose 290 Povidone K30 10 Magnesium stearate 5 beeswax 20 Lutein 3

[0055] Preparation Process:

[0056] (1) pulverizing and sieving: pulverize coenzyme Q10, microcrystalline cellulose, povidone K30, magnesium stearate, and lutein in the recipe quantities, respectively, pass coenzyme Q10 and lutein through a 65-mesh sieve, and the microcrystalline Cellulose, povidone K30, and magnesium stearate were respectively passed through a 24-mesh sieve;

[0057] (2) mixing; the coenzyme Q10 and lutein sieved in step (1) were placed in a mixer and mixed for 5min, added microcrystalline cellulose, povidone K30, magnesium stearate and continued to mix for 10min, and then added Beeswax mixed for 10min;

[0058] (3) G...

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Abstract

The invention belongs to the technical field of medicine oral solid preparations, and particularly relates to a coenzyme Q10 tablet and a preparation method thereof. Raw materials and auxiliary materials of the coenzyme Q10 tablet comprise a tablet core and a coating layer, the tablet core comprises coenzyme Q10, microcrystalline cellulose, povidone K30, magnesium stearate, beeswax and xanthophyll, and the coating layer comprises a film coating material, amaranth and aerosil. According to the present invention, the problems of poor compressibility, low hardness, unqualified friability and the like are solved, the content uniformity is improved, the content of the related substance is reduced, and the long-term stability is improved by optimizing the auxiliary material and the use amount in the tablet core, adopting the dry granulation, improving the screening and mixing process in the prescription preparation method, and optimizing the coating process;

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical oral solid preparations, in particular to a tablet containing coenzyme Q10 and a preparation method thereof. Background technique [0002] Coenzyme Q10 is one of the substances involved in the electron transport chain and aerobic respiration in eukaryotic mitochondria. It is a quinone ring compound with a long isoprene side chain and is easily soluble in chloroform, benzene and tetrachloride. Carbon, soluble in acetone, petroleum ether and ether, slightly soluble in ethanol, insoluble in water and methanol. The biological activity of coenzyme Q10 mainly comes from the redox properties of its quinone ring and the physicochemical properties of its side chain. Coenzyme Q10 is a natural antioxidant and cell metabolism activator produced by cells, which has the functions of protecting and restoring the integrity of biofilm structure, stabilizing membrane potential, enhancing immune response, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/36A61K9/32A61K9/30A61K9/28A61K9/20A61K47/38A61K47/32A61K47/12A61K47/44A61K47/10A61K47/04A61K47/20A61P9/00A61P1/16A61P35/00A61P3/06A61P17/02A61P9/10A61P1/04A61P31/04A61P1/02A61P11/00A61P11/06A61P27/16A61P7/06A61P39/06A61P37/04A61P7/08
CPCA61K9/282A61K9/2866A61K9/2813A61K9/2054A61K9/2027A61K9/2013A61K9/2095A61K31/122A61P9/00A61P1/16A61P35/00A61P3/06A61P17/02A61P9/10A61P1/04A61P31/04A61P1/02A61P11/00A61P11/06A61P27/16A61P7/06A61P39/06A61P37/04A61P7/08Y02A50/30
Inventor 章安源王峰高贵磊臧正理高永途
Owner 山东正牧生物药业有限公司
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