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Amorphous silicon-based material and preparation method and application thereof

A base material, amorphous silicon technology, applied in the field of biomedical hemostatic materials, can solve the problems of high preparation cost, easy to form waste water, less blood loss in mice, etc., and achieve effective hemostatic performance

Active Publication Date: 2022-05-24
深圳市中科海世御生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the preparation methods of the above-mentioned amorphous silicon-based bioactive glass materials each have certain advantages, they all use the sol-gel method, which requires the use of nitrate metal oxides, and the source of raw materials is dangerous. High cost, uncontrollable composition stability, harmful substances such as organic solvents, surfactants, alkalis or acids need to be used in the preparation process, and other highly toxic organic compounds are easily introduced, and waste water is easily formed in the process, which is not conducive to large-scale production Production is also not conducive to the subsequent application in the field of biomedicine
In addition, the hemostatic performance evaluation standard of the above-mentioned materials is mainly evaluated by the rat bleeding model, but the amount of bleeding in rats is small, and it is difficult to simulate the process of heavy bleeding, high pressure, and rapid bleeding, and it is impossible to evaluate the hemostatic performance of the material more effectively.

Method used

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  • Amorphous silicon-based material and preparation method and application thereof
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  • Amorphous silicon-based material and preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] This embodiment prepares an amorphous silicon-based material, and the specific preparation method is as follows:

[0075] Weigh 142.48g SiO 2 , 54.18g CaO, 34.12g (MgCO 3 ) 4 ·Mg(OH) 2 ·5H 2 O, 14.5g NaH 2 PO 4 ·2H 2 O, 12.96g anhydrous Na 2 CO 3 , 24.28g anhydrous K 2 CO 3 Place in a ceramic jar and mix well with a ternary mixer. Add the mixed powder into a platinum crucible, keep it at 1400 °C for 20 minutes to melt, then quench the glass water on a cold steel plate, and finally perform ball milling with a planetary ball mill with a ball-to-material ratio of 4:1, ball milling for 2 hours, vibrating screen The sieve is carried out by the analyzer to obtain the amorphous silicon-based material of the present invention (hereinafter referred to as OB) of the micron scale. Depend on figure 1 SEM image of 0B material. figure 2 It is the appearance diagram of 0B material.

Embodiment 2

[0077] This embodiment prepares an amorphous silicon-based material, and the specific preparation method is as follows:

[0078] Accurately weigh 106.63g SiO 2 , 37.68g H 3 BO 3 , 96.50g CaCO 3 , 20.45g Mg(OH) 2 , 42.25gSrCO 3 , 13.67g NaH 2 PO 4 ·2H 2 O, 13.93g anhydrous Na 2 CO 3 , 16.51g anhydrous K 2 O placed in a ceramic jar and mixed well with a ternary mixer. Add the mixed powder into a platinum crucible, keep it at 1300°C for 20 minutes to melt, then quench the glass water on a cold steel plate, and finally perform ball milling with a planetary ball mill with a ball-to-material ratio of 3:1, ball milling for 4 hours, vibrating screen The sieve is carried out by the analyzer to obtain the amorphous silicon-based material of the present invention (hereinafter referred to as 1B) in the micrometer scale.

Embodiment 3

[0080] This embodiment provides an amorphous silicon-based material, and the specific preparation method is:

[0081] Accurately weigh 77.40g SiO 2 , 164.09g H 3 BO 3 , 56.56g Ca(OH) 2 , 37.07g (MgCO 3 ) 4 ·Mg(OH) 2 ·5H 2 O, 45.25g SrCO 3 , 29.77g NaH 2 PO4 ·2H 2 O, 4.05g anhydrous Na 2 CO 3 , 26.37g anhydrous K 2 CO 3 Place in a ceramic jar and mix well with a ternary mixer. Add the mixed powder into a platinum crucible, keep at 1200 °C for 20 minutes to melt, then quench the glass water on a cold steel plate, and finally perform ball milling with a planetary ball mill with a ball-to-material ratio of 2:1, ball milling for 6 hours, vibrating screen The micrometer-scale borosilicate bioactive glass material (hereinafter referred to as 2B) is obtained by sieving through the analyzer.

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Abstract

The invention discloses an amorphous silicon-based material as well as a preparation method and application thereof, and the amorphous silicon-based material comprises the following components in parts by mole: 20 to 60 parts of SiO2, 10 to 30 parts of CaO, 5 to 10 parts of MgO, 0.1 to 5 parts of Na2O and 0.1 to 5 parts of K2O. According to the amorphous silicon-based material disclosed by the invention, through synthesis of the raw materials, efficient and rapid hemostasis of the hemostatic material under rapid wetting is realized, and meanwhile, the material has excellent antibacterial and healing-promoting properties while being biodegraded.

Description

technical field [0001] The invention relates to the technical field of biomedical hemostatic materials, in particular to an amorphous silicon-based material and a preparation method and application thereof. Background technique [0002] More than 5 million people die due to massive hemorrhage every year in the world. Studies have shown that when massive hemorrhage occurs, effective control of hemorrhage can increase the survival rate by 10%-20%. The first step in the hemostasis process of limb bleeding is to use hemostatic bandages and hemostatic materials; at the same time, problems such as hemorrhagic shock, hypoxia, analgesia, and anti-infection should be considered to ensure self-rescue. [0003] In the prior art, both powder and impregnated gauze hemostatic materials have problems of effectiveness, safety and complicated use and operation; for example, Z-Medica Company produces the third-generation product "CombatGauze", the main active ingredient of which is crystallin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C03C3/097C03C3/064A61L24/02A61L24/00
CPCC03C3/097C03C3/064A61L24/02A61L24/0015A61L24/0042A61L2400/04A61L2300/404A61L2300/412A61L2300/418
Inventor 潘浩波柳春玉崔旭
Owner 深圳市中科海世御生物科技有限公司
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