Composition, preparation method and application in preparation of deck coating product

Abstract

The invention relates to the field of preparation of compositions, in particular to a composition, a preparation method and application of the composition in preparation of deck coating products. The nano-dosage bacteriostatic agent and more than two water-soluble film-forming agents are compounded, the bacteriostatic agent can be stably compounded with the water-soluble film-forming agents after being subjected to nanocrystallization treatment, the mechanical property of the composition after film forming is improved to a certain extent due to the increase of the number of the film-forming agents, and due to the water solubility of the film-forming agents, the film-forming effect of the composition is improved. And the nanocrystallized bacteriostatic agent can be stably released to play a role in antibacterial treatment. After the composition provided by the invention is coated, a film containing a nanocrystallization bacteriostatic agent is formed, so that the effects of protecting a wound surface, isolating an external environment, lasting drug effect, small toxic and side effects and gradually releasing contained drugs are realized, and meanwhile, the composition is also convenient and quick to use and change medicine during use.

Description

Technical field [0001] The present invention relates to the field of preparation of compositions, in particular to compositions, preparation methods and applications in the preparation of deck coating products. Background [0002] Onychomycosis is an infectious disease caused by the invasion of fungi such as dermatophytes, yeasts and non-dermatophytes into the deck or subarychoidine, and is the most stubborn type of dermatophytosis. Traditional treatments include: [0003] 1. Surgical nail extraction [0004] This method is suitable for single nails, there is usually pain after surgery, and it is easy to re-infect and recur, and it has been rarely used clinically, especially for the treatment of onychomycosis in patients with heart disease, hypertension and diabetes, etc. This method is not suitable for this method. [0005] 2. Internal medication [0006] This method is suitable for multiple finger (toe) nails, commonly used drugs are terbinafine, itraconazole and fluconazole, ...

AI Technical Summary

Problems solved by technology

[0008] This method is mainly based on topical application and package treatment. The drugs that can be used for topical application include terbinafine tincture, amorolfine A liniment and ciclopirox ketone A varnish, etc., for example, the patent The topical antifungal composition of CN105050592A treatment onychomycosis and the patent CN1307971C antifungal nail polish composition all provide the coating composition for onychomycosis, but the medicinal component terbinafine wherein also exists insoluble in The problem of water, at the same time, compared with other dermatological coating treatments, the mechanical properties of the composition layer formed by deck coating are higher, and the improvement of the mechanical properties of the coating layer will lead to a decrease in the release rate of effective medicinal components Therefore, it is necessary to provide a coating layer that has both good mechanical properties to meet the needs of deck coating, while ensuring a good release rate of medicinal components

Images