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Application of traditional Chinese medicine composition in preparation of medicine for treating podocytosis

A composition and podocyte technology, which can be used in drug combinations, pharmaceutical formulations, plant raw materials, etc., and can solve problems such as obvious side effects

Pending Publication Date: 2022-05-06
JIANGSU KANGYUAN SUNSHINE PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The main drugs currently used to treat podocyte disease include glucocorticoids, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, statins, and all-trans retinoic acid, among which glucocorticoids are more commonly used. Many, but its side effects are also very obvious

Method used

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  • Application of traditional Chinese medicine composition in preparation of medicine for treating podocytosis
  • Application of traditional Chinese medicine composition in preparation of medicine for treating podocytosis
  • Application of traditional Chinese medicine composition in preparation of medicine for treating podocytosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation of embodiment 1 Chinese medicine composition

[0033] Take Radix Polygoni Multiflori and cooked rhubarb and crush them into coarse powder, use 60-80% ethanol as solvent, soak for 12-36 hours, then percolate at a speed of 1-3 ml / min, collect percolation liquid, recover ethanol from percolation liquid , concentrated liquid extract;

[0034] Separately take bran-fried Atractylodes atractylodis and crush them into coarse powder, add 2-8 times the amount of water to soak for 2 hours, steam distillation to extract volatile oil, and save the distilled medicinal residue and medicinal liquid;

[0035] The above-mentioned volatile oil is dissolved in ethanol at a ratio of 1:1, and the colloidal milling method is used. The ratio of volatile oil to β-cyclodextrin is 1:5-15, and the ratio of β-cyclodextrin to water is 1:1-3. The grinding surface distance is 3-7 microns, the grinding speed is 3000 rpm, and the inclusion compound is obtained by grinding for 10-20 minu...

Embodiment 2

[0038] The protective effect of embodiment 2 Chinese medicine composition on podocyte injury animal model

[0039] (1) Construction of a rat model of podocyte injury

[0040] The rats were fed with normal feed freely, and the urine protein level of the rats was detected after 7 days of adaptive feeding, and the rats with normal urine protein level were included in the experiment. 6 of the 30 rats were randomly selected as the blank group, and the remaining 24 rats were used for the construction of the disease model. The rats were fixed in the tail vein syringe, and the tails of the rats were sterilized with 75% ethanol. Adriamycin hydrochloride (6 mg / kg) was injected, and the blank group was injected with equal volume of 0.9% sodium chloride injection into the tail vein. 2 weeks after modeling, the 24h urine protein was detected. If the 24h urine protein>50mg, the modeling was successful.

[0041] (2) drug treatment

[0042] The positive drug that is used for treatment is p...

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Abstract

The invention provides novel application of a traditional Chinese medicine composition for treating podocytosis. Specifically, the composition consists of twelve traditional Chinese medicinal materials such as radix polygoni multiflori preparata, semen cuscutae, radix pseudostellariae, rhizoma atractylodis stir-fried with bran, fructus lycii, radix achyranthis bidentatae, herba lycopi, radix paeoniae rubra, poria cocos, rhizoma alismatis, semen plantaginis and cooked rhubarb, and is used for treating, preventing and relieving podocytosis such as nephrotic syndrome, focal segmental glomerulosclerosis and the like.

Description

technical field [0001] The application relates to the field of traditional Chinese medicine, in particular to the application of a traditional Chinese medicine composition in the preparation of medicines for treating podocyte disease. Background technique [0002] Podocytes are one of the major resident cells of the glomerulus and consist of three structurally and functionally distinct parts, including the cell body, primary processes, and secondary processes. The secondary protrusions are also called foot processes. The foot processes of adjacent podocytes cross each other to form a zipper-like slit diaphragm (SD). Completeness plays an important role. Podocytes are terminally differentiated cells that lack regenerative capacity after shedding. Therefore, once podocytes are damaged, proteinuria will occur, and abnormalities in serum lipids, albumin and other indicators will occur. [0003] Podocyte disease includes nephrotic syndrome, focal segmental glomerulosclerosis, m...

Claims

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Application Information

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IPC IPC(8): A61K36/884A61K47/69A61P13/12
CPCA61K36/704A61K36/39A61K36/43A61K36/36A61K36/284A61K36/815A61K36/21A61K36/53A61K36/71A61K36/65A61K36/076A61K36/884A61K36/68A61K36/708A61K47/6951A61P13/12A61K2236/333A61K2236/51A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 肖伟李旭张全昌顾莎莎王团结章晨峰王振中
Owner JIANGSU KANGYUAN SUNSHINE PHARMA CO LTD
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