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Application of cordyceps guangdongensis sporocarp polysaccharide in preparation of medicine for treating and improving obesity and related diseases

A technology of Cordyceps fruiting body, Guangdong Cordyceps, applied in the field of biomedicine and health care products, can solve problems such as efficacy research has not been reported, and achieve the effect of improving liver coefficient, reducing content and protecting liver

Active Publication Date: 2022-05-06
GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research on the efficacy of fruiting body polysaccharides of Cordyceps guangdong in alleviating obesity, lowering blood lipids and other related metabolic diseases has not been reported so far.

Method used

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  • Application of cordyceps guangdongensis sporocarp polysaccharide in preparation of medicine for treating and improving obesity and related diseases
  • Application of cordyceps guangdongensis sporocarp polysaccharide in preparation of medicine for treating and improving obesity and related diseases
  • Application of cordyceps guangdongensis sporocarp polysaccharide in preparation of medicine for treating and improving obesity and related diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Preparation of polysaccharides from the fruiting body of Cordyceps guangdongensis.

[0031] The fruiting bodies of Cordyceps guangdong dried in an oven at 50-60°C were made into ultra-fine powder with an ultra-low temperature pulverizer (-20--15°C), weighed 150g, added 375mL of petroleum ether, degreased at room temperature until colorless, and placed in a fume hood Volatile petroleum ether. Then, add 1.5L of distilled water, place it in a water bath at 90°C for 2 hours, stir once every 30 minutes; centrifuge at 5500 rpm for 15 minutes at 4°C, take the supernatant, and repeat the extraction once. The two supernatants were combined and concentrated to 1L in a rotary evaporator, then 3L of 95% ethanol was added, precipitated at 4 °C for 16 h, centrifuged at 5500 rpm for 15 min, discarded the supernatant, collected the precipitate and dehydrated twice with absolute ethanol. Then, place the precipitate in an oven at 60° C. to dry to obtain polysaccharides from the fruit bo...

Embodiment 2

[0033] Grouping, modeling and administration of mice, the specific steps are as follows:

[0034] 1. Grouping of mice: The experimental animals are SPF grade male C57BL / 6J mice, 7 weeks old, weighing 19-21g, a total of 90 were raised in the Experimental Animal Center of the Institute of Microbiology, Guangdong Academy of Sciences, the ambient temperature was 21±2°C, and the humidity 55±10%, light and dark alternately for 12h. After acclimating to the environment for 1 week, the mice were randomly divided into 3 treatments (control group, high-fat group and polysaccharide group), and each treatment had 3 groups with 10 mice in each group.

[0035]2. Modeling and administration: the mice in the control group were fed with conventional feed (Jiangsu Synergy Pharmaceutical Bioengineering Co., Ltd.), and the mice in the high-fat group and polysaccharide group were fed with 60% fat high-fat feed D12492 (mass ratio: Casein 200, l-cystine 3, sucrose 68.8, maltodextrin 12.5, cellulose...

Embodiment 3

[0037] Determination of weight loss and other related indicators and observation of liver pathological sections.

[0038] 1. The effect of polysaccharides from the fruiting bodies of Cordyceps guangdong on the glucose tolerance of mice:

[0039] Two weeks before the collection of samples, the mice were fasted for 12 hours, and the tip of the tail was cut off by 0.2 mm to 0.3 mm with sterilized surgical scissors. Blood was collected from the wound, and the fasting blood glucose level (0 min) was tested with a blood glucose meter. Glucose solution (1g / kg body weight) was administered intragastrically, and blood glucose values ​​were tested at 15min, 30min, 60min, 90min and 120min, respectively. The specific data are shown in Table 1.

[0040] Table 1 Cordyceps guangdong fruiting body polysaccharide improves glucose tolerance in obese mice

[0041]

[0042]

[0043] Note: a, b, c, extremely significant difference (P<0.01).

[0044] The result is as figure 1 As shown in ...

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Abstract

The invention discloses application of cordyceps guangdongensis sporocarp polysaccharide in preparation of drugs for treating and improving obesity and related diseases. The invention provides application of cordyceps guangdongensis sporocarp polysaccharide in preparation of drugs for treating and improving obesity and related diseases. In the aspects of relieving obesity, reducing blood fat and protecting the liver, the cordyceps guangdongensis sporocarp polysaccharide plays a positive role and shows good development and application prospects, and the application field of the cordyceps guangdongensis sporocarp polysaccharide is greatly expanded.

Description

Technical field: [0001] The invention belongs to the field of biomedicine and health care products, and in particular relates to the application of fruiting body polysaccharide of Cordyceps guangdong in the preparation of medicines for treating and improving obesity and related diseases. Background technique: [0002] With the improvement of people's living standards, excessive intake of nutrients leads to fat accumulation in the body, which in turn causes obesity and related metabolic chronic metabolic disorders. At present, obesity has become a common and serious public health problem. It not only causes differences in body posture, but also causes chronic metabolic syndrome, such as hyperglycemia, hyperlipidemia, hypertension, type 2 diabetes, Fatty liver, coronary heart disease, colon cancer, Alzheimer's disease and other diseases have become an important invisible "killer" restricting people's health. Hyperlipidemia, a major complication of obesity, is a systemic disea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P3/04A61P3/06A61P1/16C08B37/00
CPCA61K31/715A61P3/04A61P3/06A61P1/16C08B37/0003
Inventor 王刚正王超群张明邓旺秋孙程远张成花李挺黄浩黄秋菊李泰辉
Owner GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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