Targeting peptide modified cosmetic peptide composition

Abstract

The invention discloses a cosmetic peptide composition modified by a targeting peptide. The cosmetic peptide composition is a covalent / non-covalent compound composed of a targeting peptide and a cosmetic peptide. The targeting peptide is a linear or annular peptide composed of 3-30 amino acids, and comprises RGD polypeptide of targeting cell surface integrin alpha v beta 3, Otx2 polypeptide of targeting cell surface chondroitin sulfate or cell-penetrating peptide in targeting cell. The cosmetic peptide comprises acetylated, fatty acid acylated or non-acylated active peptides which are common in the market and exert effects inside and outside cells, and the targeted cosmetic peptide composition does not affect the activity of the cosmetic peptide, is used for skin cosmetic treatment, promotes cell surface aggregation or intracellular guidance of the cosmetic peptide, and improves the skin whitening effect. According to the cosmetic peptide, the combination opportunity of the cosmetic peptide and intracellular and extracellular receptors is improved, the use effect of the cosmetic peptide is enhanced, especially the effects of resisting oxidation and aging, increasing the collagen content of skin tissue and repairing the keratinous structure of skin cells are achieved, and the cosmetic peptide has good application potential in the field of cosmetic raw materials.

Description

technical field [0001] The invention relates to the technical field of anti-oxidation and anti-aging skin care products, in particular to a cosmetic peptide composition modified by targeting peptides. Background technique [0002] Bioactive peptides are derived from proteins and are usually functional peptide fragments containing 3-30 amino acids linked by amide bonds. Bioactive peptides can be signaling molecules that maintain the body's normal physiological responses, or they can be substrates that directly participate in life responses. Cosmetic peptides are a class of bioactive peptides with beauty and skin care effects. Common cosmetic peptides can improve the survival rate and proliferation rate of aging human epidermal cells or skin fibroblasts, stimulate the activity of skin tissue, and increase the movement of stromal cells; they can also effectively remove the accumulation of pigment, reduce inflammation, and promote extracellular matrix, collagen Synthesis of ce...

AI Technical Summary

Problems solved by technology

[0008] The present invention provides a cosmetic peptide composition modified with targeting peptides, which solves the problem of high effective dosage of cosmetic peptides in the prior art because the cosmetic peptides have no targeting effect and cannot be enriched to the cell surface to play a role. , the cost increases, and the toxicity increases; and usually the molecular weight of cosmetic peptides is relatively large, so the ability to penetrate the skin and freely pass through cells is weak, which reduces the efficacy of intracellular cosmetic peptides and other technical problems

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