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In-vivo biological neural information detection method

A detection method and color center technology, which is applied in the field of detection of in vivo biological nerve information, can solve problems such as difficult array integration, inability to realize electromagnetic wave signal detection, inapplicability of biological nerve in vivo detection experiments, etc., and achieve the effect of improving detection sensitivity

Active Publication Date: 2022-04-15
NAT INNOVATION INST OF DEFENSE TECH PLA ACAD OF MILITARY SCI
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  • Abstract
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Problems solved by technology

Although the sensitivity of coherent detection is much higher than that of direct detection, it is difficult to integrate large-scale arrays due to the limitation of local oscillator signals, and it is not suitable for in vivo detection experiments of biological nerves.
[0005] In the study of the various functions played by electromagnetic waves in the process of nerve signal transmission, the technical scheme of using a synchrotron radiation light source with a Fourier infrared spectrometer can measure the transmission and absorption spectra of biological nerve samples in the mid- and far-infrared bands, but its Imaging resolution cannot break through the characteristic scale of nerve cells, and it is difficult to maintain the activity of biological nerve tissue
In addition, in a technology that realizes the active detection of high-frequency electromagnetic conduction of living nerves, the biological nerve is placed in a nerve bend filled with physiological fluid and circulated to maintain the activity of nerve tissue, which can effectively avoid incident electromagnetic wave interference in the detection of high-frequency electromagnetic conduction of nerves However, it is impossible to realize in situ electromagnetic wave signal detection of biological nerves in vivo

Method used

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Embodiment 1

[0036] The present embodiment provides a kind of preparation of nano-diamond color center particle, specifically as follows:

[0037] Diamond crystals are suitable for single-spin magnetic resonance systems, specifically: (1) there is no spin-orbit coupling in diamond crystals; (2) the bonding between atoms in diamond is very strong, and the influence of lattice vibration on electronic states is weak; (3) Isotopes in diamond 13 The abundance of C is relatively low, only about 1.1% in natural diamond, and the number of atoms with nuclear magnetic moments is small, and this abundance can also be greatly reduced in the prepared diamond material through artificial control. These three mechanisms make the spin decoherence mechanism weak in diamond crystals, and the spin coherence is kept for a long time.

[0038]Natural diamond is produced in the environment of high temperature and high pressure in the earth's crust. Under this condition, diamond is a stable phase of carbon. The p...

Embodiment 2

[0043] This embodiment provides a detection platform for the spin state of a diamond color center based on the diamond color center provided in Embodiment 1, specifically as follows:

[0044] The detection platform mainly includes optical confocal system, adjustable magnetic field system, terahertz system and electronic control system. The core of the optical part is a confocal system, which is mainly used for the initialization and readout of the single spin of the diamond color center for room temperature equipment.

[0045] like figure 2 As shown, the laser with a wavelength of 450nm passes through the acousto-optic modulator and beam expander, and is focused on the diamond color center by a microscope lens with a high numerical aperture (NA=1.4). Fluorescence emitted by a single diamond spin is spatially filtered and collected by a single-photon detector. The key parameter is the lateral resolution of about 200nm, which is mainly limited by the optical diffraction limit...

Embodiment 3

[0049] This embodiment provides a terahertz detection method in a living body, based on the detection platform of the diamond color center spin state provided in Embodiment 2, the specific steps are as follows:

[0050] 1. Prepare nano-diamond color center crystal particles by ball milling method, inject Pb element into high-purity diamond crystal by ion implantation method, the implantation depth is 10nm, and the ion implantation surface density is about 10 9 piece / cm 2 .

[0051] Afterwards, it is annealed for 10 hours in a vacuum and high temperature environment at 650°C to move the lattice holes in the crystal, and the heavy ions reside in the middle of the two lattice holes to form a nano-diamond color center with stable optical properties.

[0052] 2. Put nano-diamond color center crystal particles into living biological nerves (white mice or bullfrogs), and put them on the optical detection magnetic resonance detection platform.

[0053] Wrap the phospholipid bimolecu...

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Abstract

The invention relates to a biological neural information in-vivo detection technology, in particular to an in-vivo biological neural information detection method. The detection method comprises the following steps: placing a nano-diamond color center with terahertz electromagnetic field detection capability in organism nerves, irradiating by adopting laser in a visible light-near infrared light band, and polarizing / reading a spin state of the diamond color center, so as to realize detection of terahertz signals in the organism nerves. The nano-diamond color center is doped with heavy ion elements; and the ground state energy level of the heavy ion element color center is split in a terahertz frequency band. The nano-diamond color center provided by the invention can be used as an atomic weight level sensor, has extremely high spatial resolution, also has relatively long coherence time at room temperature, and can realize in-situ and high-sensitivity biological nerve terahertz electromagnetic signal measurement.

Description

technical field [0001] The invention relates to an in vivo detection technology of biological nerve information, in particular to a detection method of in vivo biological nerve information. Background technique [0002] The human nervous system should be the most scientific, efficient and effective integrated network information system in the world. Based on the classic neural electrical signal and chemical signal theory, it is believed that the physiological mechanism of information encoding, transmission and processing of the nervous system has been partially understood, which can well explain the low-level functions of the nervous system such as sensation, movement, and reflection. Extensive experimental research on neural electrical and chemical signals is still difficult to construct general concepts and principles for explaining the advanced functions of the nervous system, such as perception, motor control, learning, memory, emotion, will, and consciousness, and other...

Claims

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Application Information

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IPC IPC(8): A61B5/00
Inventor 常超罗治福钟原黄崟东王睿星杨霄陈硕冯逸飞
Owner NAT INNOVATION INST OF DEFENSE TECH PLA ACAD OF MILITARY SCI
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