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Packaging container for inhibiting color change of tobramycin eye drops and preparation method thereof

A packaging container and tobramycin technology, applied in the field of ophthalmic medicine, can solve the problems of tobramycin eye drops being unstable and easy to change, so as to ensure clinical efficacy, improve stability, and improve color changes. Effect

Pending Publication Date: 2022-04-01
SHENYANG XINGQI PHARM CO LTD
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0011] The present invention proposes to solve the problem in the prior art that the color of tobramycin eye drops is prone to change when stored for a long time, resulting in the instability of tobramycin eye drops. Discoloration of bumycin eye drops, packaging container for improving stability of tobramycin eye drops and preparation method thereof

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  • Packaging container for inhibiting color change of tobramycin eye drops and preparation method thereof
  • Packaging container for inhibiting color change of tobramycin eye drops and preparation method thereof
  • Packaging container for inhibiting color change of tobramycin eye drops and preparation method thereof

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[0056] The invention and its advantages will be described in detail below by means of exemplary embodiments. The description of the exemplary embodiments is illustrative only, and in no way serves as any limitation of the disclosure, its application or uses. The present disclosure can be implemented in many different forms and is not limited to the embodiments described here. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art. It should be noted that unless otherwise stated, the relative arrangement of components and steps, material composition, numerical expressions and numerical values, etc. set forth in these embodiments should be interpreted as merely exemplary and not limiting.

[0057] Those not specified in the exemplary embodiments shall be carried out according to the conventional conditions or the conditions suggested by the manufacturer. The rea...

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Abstract

The invention relates to a packaging container for inhibiting color change of tobramycin eye drops and a preparation method of the packaging container. The existing tobramycin eye drops have the defect of unstable quality caused by color change during the stability inspection period, so that the invention provides a novel method for stabilizing the tobramycin eye drops, namely, a color master batch containing specific titanium dioxide is added into a container material of a tobramycin eye drop packaging container; the color of the tobramycin eye drops is kept unchanged during the stability inspection period, and the product quality is improved, so that the clinical curative effect of the tobramycin eye drops is ensured.

Description

technical field [0001] The invention relates to the field of ophthalmic medicines, in particular to a packaging container for inhibiting discoloration of tobramycin eye drops to improve the stability of tobramycin eye drops and a preparation method thereof. Background technique [0002] For ocular conjunctivitis, keratitis, iritis and other eye diseases caused by bacterial infection of the eye, commonly used eye drops include gentamicin, ofloxacin, kanamycin, polymyxin beta However, with the prolongation of clinical use and the increase in the frequency of use, the above-mentioned drugs have developed drug resistance and cross-resistance to bacteria such as Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, etc. big impact. [0003] Tobramycin is an aminoglycoside antibiotic with the molecular formula C 18 h 37 N 5 o 9 , the molecular weight is 467.52, and the structural formula is as follows: [0004] [0005] Its chemical structure is similar to that...

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Application Information

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IPC IPC(8): C08L23/06C08L23/30C08K3/34C08K5/098C08K3/22C08J3/22
Inventor 刘继东杨强李丹刘超
Owner SHENYANG XINGQI PHARM CO LTD
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