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Synthetic process of ascorbyl tetraisopalmitate

A technology of ascorbic acid and palmitate, applied in the direction of metal/metal oxide/metal hydroxide catalyst, catalyst activation/preparation, organic chemistry, etc., can solve problems such as cost reduction, achieve cost reduction, facilitate recycling, promote The effect of catalytic activity

Active Publication Date: 2022-03-25
南京先达医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problems in the prior art, the present invention provides a kind of synthetic technique of ascorbyl tetraisopalmitate, which solves the existing technique of ascorbyl tetraisopalmitate Defects, the solid catalyst is used as the activation reaction point to promote the aldol reaction effect, and at the same time facilitate the recycling of the catalyst, which greatly reduces the cost

Method used

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Effect test

Embodiment 1

[0021] A kind of synthetic technique of ascorbyl tetraisopalmitate, comprising:

[0022] 1. Preparation of modified niobic acid:

[0023] The modified niobic acid uses tourmaline powder as the core and niobium hydroxide as the shell; the preparation method of the modified niobic acid comprises the following steps: a1, adding tourmaline powder to ethanol and stirring evenly, and putting it into a ball mill Ball milling to obtain tourmaline slurry, the mass ratio of the tourmaline powder to ethanol is 5:4, the stirring speed is 200r / min, the temperature of the ball milling is 30°C, and the ball milling pressure is 0.4MPa; a2, five Niobium chloride was added into n-propanol and stirred evenly, then poured into the tourmaline slurry and continuously stirred evenly, and then ultrasonically dispersed for 20 minutes until a homogeneous slurry was formed to obtain a mixed slurry. The concentration in the tourmaline slurry is 100g / L, the mass ratio of tourmaline and niobium pentachlor...

Embodiment 2

[0028] A kind of synthetic technique of ascorbyl tetraisopalmitate, comprising:

[0029] 1. Preparation of modified niobic acid:

[0030] The modified niobic acid uses tourmaline powder as the core and niobium hydroxide as the shell; the preparation method of the modified niobic acid comprises the following steps: a1, adding tourmaline powder to ethanol and stirring evenly, and putting it into a ball mill Ball milling treatment to obtain tourmaline slurry, the mass ratio of the tourmaline powder and ethanol is 10:4, the stirring speed is 500r / min, the temperature of the ball milling treatment is 50°C, and the ball milling pressure is 0.7MPa; a2, five Niobium chloride was added into n-propanol and stirred evenly, then poured into the tourmaline slurry and continuously stirred evenly, and then ultrasonically dispersed for 30 minutes until a homogeneous slurry was formed to obtain a mixed slurry. The concentration in the tourmaline slurry is 200g / L, the mass ratio of tourmaline ...

Embodiment 3

[0035] A kind of synthetic technique of ascorbyl tetraisopalmitate, comprising:

[0036] 1. Preparation of modified niobic acid:

[0037]The modified niobic acid uses tourmaline powder as the core and niobium hydroxide as the shell; the preparation method of the modified niobic acid comprises the following steps: a1, adding tourmaline powder to ethanol and stirring evenly, and putting it into a ball mill Ball milling treatment to obtain tourmaline slurry, the mass ratio of the tourmaline powder and ethanol is 8:4, the stirring speed is 400r / min, the temperature of the ball milling treatment is 40°C, and the ball milling pressure is 0.6MPa; a2, five Niobium chloride was added into n-propanol and stirred evenly, then poured into the tourmaline slurry and continuously stirred evenly, and then ultrasonically dispersed for 25 minutes until a homogeneous slurry was formed to obtain a mixed slurry. The concentration in is 150g / L, and the mass ratio of tourmaline in described tourmal...

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PUM

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Abstract

The invention belongs to the field of organic synthesis, and particularly relates to a synthesis process of ascorbyl tetraisopalmitate, which is characterized in that 2-hexylcapraldehyde and L-ascorbic acid are used as raw materials, modified niobic acid is used as a catalyst, and an oxide is matched for oxidative esterification reaction to obtain the ascorbyl tetraisopalmitate. According to the method disclosed by the invention, the process defects of the existing ascorbyl tetraisopalmitate are overcome, the aldol reaction effect is promoted by taking the solid catalyst as an activation reaction point, meanwhile, the catalyst is convenient to recycle, and the cost is greatly reduced.

Description

technical field [0001] The invention belongs to the field of organic synthesis, and in particular relates to a synthesis process of ascorbyl tetraisopalmitate. Background technique [0002] Ascorbyl tetraisopalmitate, as an important ascorbic acid derivative, is a fat-soluble antioxidant. It not only retains the anti-oxidation of ascorbic acid, namely vitamin C, and the pharmacological effects of preventing vascular sclerosis and treating sepsis, but also has fat solubility. It is a highly efficient and multi-functional additive that extends the scope of application of the product. In medicine, it is used as an antioxidant, stabilizer, and synergist in medicine; in health food, it is mainly used as an antioxidant and nutritional enhancer for human body; in the field of cosmetics, it is mainly used as an additive for cosmetics. [0003] Ascorbyl tetraisopalmitate is stable at high temperature, has good solubility in oil, and has excellent transdermal absorption ability, and ...

Claims

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Application Information

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IPC IPC(8): C07D307/62B01J23/20B01J21/16
CPCC07D307/62B01J23/20B01J21/16B01J37/0215B01J37/0036B01J35/397Y02P20/584
Inventor 曹璨李祥祥王兆敏
Owner 南京先达医药科技有限公司
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