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Injection gel containing controllably degradable polyester microspheres

A technology for degrading polyester and polyester microspheres, applied in the field of medical cosmetic materials, can solve the problems of collapse of the microsphere structure, particle adhesion, and the inability of PLLA microspheres to exist stably for a long time, so as to repair wrinkles and improve subcutaneous volume. Effect

Active Publication Date: 2022-03-22
HANGZHOU SINGCLEAN MEDICAL PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, studies have found that PLLA microspheres cannot exist stably for a long time in an aqueous environment, and problems such as microsphere structure collapse or particle adhesion may occur when stored for more than one month

Method used

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  • Injection gel containing controllably degradable polyester microspheres
  • Injection gel containing controllably degradable polyester microspheres
  • Injection gel containing controllably degradable polyester microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] S1: Preparation of PLLA microspheres wrapped in mixed fatty acid glycerides: 38-type mixed fatty acid glycerides were dissolved in petroleum ether to 2% solution; stirring, PLLA microspheres were added to the solution, making microspheres uniformly dispersed; The microspheres were separated from the solution.

[0038] S2: 10.0 g of sodium hyaluronate (dry powder) is dissolved in 100 ml of purified water, and then add 120 μl of crosslinking diendyl sulfone to the solution to mix well, add 30.5 g of mixed fatty acid glyceride wrapped in PLLA microspheres, stir After uniform reactions, 2 to 18 hours form a microspheres of cross-linking hyaluronicate;

[0039] S3: Brass the above gel into 1 ~ 2cm 3 The small gel block, then soaked, dialysis using a balanced salt solution;

[0040] S4: The gel after subjected to a dispersing machine, then the mass of 10% of the unfringed hyaluronicate (sodium sodium sodium sodium sodium sodium-sodium) is added to the balanced salt solution), and...

Embodiment 2

[0047] S1: Preparation of Glyceride (PCL) microspheres for mixed fatty acid glycerides: 36-type mixed fatty acid glycerides are prepared in chloroform into 6% solution; stirring, add PCL microspheres to solutions Make the microspheres uniformly dispersed; filtrate, separated the microspheres with the solution, the microspheres are placed in a normal temperature drum tank until the fatty acid glyceride wrapped PCL microspheres;

[0048] S2: 10.0 g of hyaluronate (dry powder) is dissolved in 100 ml of purified water, and then 120 μl of crosslinking diendoxide was added to the solution and mixed, then 11.4 g of a PCL microsphere wrapped in mixed fatty acid glyceride, stirred After uniform reactions, 2 to 18 hours form a microspheres of cross-linking hyaluronicate;

[0049] S3: Brass the above gel into 1 ~ 2cm 3 The small gel block, then soaked, dialysis using a balanced salt solution;

[0050] S4: The gel after subjected to a dispersing machine, then the mass of 10% of the unfringed ...

Embodiment 3

[0053] S1: Preparation of PLLA microspheres wrapped in mixed fatty acid glycerides: 37-type mixed fatty acid glyceride is dissolved in diethyl ether to 0.5% solution; stir it, add PLLA microspheres to the solution, make microspheres uniformly dispersed; Filter, separated the microspheres with the solution, and the microspheres were placed in a normal temperature shirt until drying, i.e., the PLLA microspheres wrapped in fatty acid glycerides;

[0054] S2: 10.0 g of hyaluronate (dry powder) is dissolved in 100 ml of purified water, and then 120 μl of crosslinking diendyl sulfone is added to the solution and mix, add 51.0 g of a PLLA microsphere wrapped in fatty acid glyceride, stir After uniform reactions, 2 to 18 hours form a microspheres of cross-linking hyaluronicate;

[0055] S3: Brass the above gel into 1 ~ 2cm 3 The small gel block, then soaked, dialysis using a balanced salt solution;

[0056] S4: The gel after subjected to a dispersing machine, then the mass of 10% of the u...

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Abstract

The invention provides injection gel containing controllably degradable polyester microspheres. The injection gel is prepared from cross-linked sodium hyaluronate gel, non-cross-linked sodium hyaluronate gel, polyester microspheres wrapped by mixed fatty glyceride and a balanced salt solution. The polyester microspheres are separated from water by means of wrapping and hydrophobic effects of the mixed fatty glyceride, and the problem that a polyester material is easy to degrade in gel is solved. Meanwhile, the mixed fatty glyceride has the characteristic of low melting point (the melting point is 33-39 DEG C), and after the product is injected into a human body, the mixed fatty glyceride is melted, separated and released to wrap the polyester microspheres under the action of the body temperature of the human body, so that the microspheres can be degraded in the human body, and the characteristic of controllable degradation is realized. When the prepared gel for injection is not used, the microspheres contained in the gel can be stored at normal temperature in a non-degradation or micro-degradation mode, after the gel is injected and used, a wrinkle area is filled with the microspheres, the microspheres are released, subcutaneous collagen growth is stimulated along with in-vivo degradation of the microspheres, and the effect of improving skin wrinkles in a long-acting mode is achieved.

Description

Technical field: [0001] The present invention relates to a gel for injection of controlled degradation of polyester microspheres, belonging to the technical field of medical beauty materials. Background technique: [0002] With the development of the medical beauty industry, the injection materials used to repair facial wrinkles are increasingly concerned. At present, these injection materials have two major categories. One is the filler product represented by cross-linking hyaluronate sodium gel, collagen gel, and the main mechanism is subcutaneous filled. After injection, the subcutaneous defect is expanded. Filled , Smooth wrinkles; the other is collagen stimulating products represented by polylactic acid (PLLA) microspheres, such as SCULPTRA in the United States. TM Such products are in the degradation process by stimulating a large number of macrophages and other immune cells, resulting in the proliferation of fibroblasts and their muscle fibroblasts, and to restore their pl...

Claims

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Application Information

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IPC IPC(8): A61L27/52A61L27/20A61L27/18A61L27/58A61L27/50C08J3/075C08L5/08C08L67/04
CPCA61L27/52A61L27/20A61L27/18A61L27/58A61L27/50C08J3/075C08J2305/08C08J2405/08C08J2467/04A61L2400/06A61L2300/622C08L5/08C08L67/04A61Q19/08A61K8/735A61K8/85A61K8/042A61K8/025A61K2800/412A61K2800/62A61K2800/654A61K2800/91A61K8/92A61K2800/24A61K2800/95
Inventor 李杰付洋周翠英伍飞飞马矢徒
Owner HANGZHOU SINGCLEAN MEDICAL PROD
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