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Preparation method of controllably degradable component gradient magnesium-based implant material

An implant material and composition gradient technology, which is applied in the preparation of biomedical magnesium-based materials and the preparation of composition gradient magnesium-based implant materials, can solve the problems of low degradation rate and mechanical properties, improve stability and safety, reduce Degradation rate, effect on improving mechanical properties and tissue compactness

Active Publication Date: 2022-02-25
JIANGSU UNIV OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problems of rapid degradation and relatively low mechanical properties of current medical magnesium alloy materials that affect the application in the field of clinical medicine, the present invention provides a method for preparing a controllable degradation composition gradient magnesium-based implant material. By adopting techniques such as casting, heat treatment, friction stir processing, and rolling, the preparation of a magnesium-based implant material with controllable degradation and composition gradient is realized. The composition gradient of the medical magnesium alloy material prepared by the method of the present invention changes from the surface layer to the interior, The degradation rate in the implant body is controllable, which fulfills the clinical performance requirements for medical implant materials

Method used

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Experimental program
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Effect test

Embodiment 1

[0030]A method for preparing a controllable degradable composition gradient magnesium-based implant material, comprising the following specific steps:

[0031] (1) Pretreatment: Use pure magnesium, pure zinc, silicon particles and Mg-Gd alloys with a purity of not less than 99.9% as raw materials, use sandpaper to remove the oxide film on the surface of the raw materials, and then dry them in a vacuum oven at 150°C 1 hour;

[0032] (2) Casting: Calculate the required amount of each raw material according to the set composition while considering the burning loss rate of the elements, that is, batching according to the actual yield; firstly smelting to prepare large matrix alloy ingots, and then cutting into small pieces for remelting The method ensures the stability of the matrix material composition during batch experiments; the pure Mg and pure Zn ingots are cut into large pieces, and the pure Mg, Zn ingots, Si particles and Mg-Gd master alloy are placed in a vacuum induction...

Embodiment 2

[0041] A method for preparing a controllable degradable composition gradient magnesium-based implant material, comprising the following specific steps:

[0042] (1) Pretreatment: Use pure magnesium, pure zinc, silicon particles and Mg-Gd alloys with a purity of not less than 99.9% as raw materials, use sandpaper to remove the oxide film on the surface of the raw materials, and then dry them in a vacuum oven at 140°C 3 hours;

[0043] (2) Casting: Calculate the required amount of each raw material according to the set composition while considering the burning loss rate of the elements, that is, batching according to the actual yield; firstly smelting to prepare large matrix alloy ingots, and then cutting into small pieces for remelting The method ensures the stability of the matrix material composition during batch experiments; the pure Mg and pure Zn ingots are cut into large pieces, and the pure Mg, Zn ingots, Si particles and Mg-Gd master alloy are placed in a vacuum inducti...

Embodiment 3

[0052] A method for preparing a controllable degradable composition gradient magnesium-based implant material, comprising the following specific steps:

[0053] (1) Pretreatment: Use pure magnesium, pure zinc, silicon particles and Mg-Gd alloy with a purity of not less than 99.9% as raw materials, use sandpaper to remove the oxide film on the surface of the raw materials, and then dry them in a vacuum oven at 160°C 2 hours;

[0054] (2) Casting: Calculate the required amount of each raw material according to the set composition while considering the burning loss rate of the elements, that is, batching according to the actual yield; firstly smelting to prepare large matrix alloy ingots, and then cutting into small pieces for remelting The method ensures the stability of the matrix material composition during batch experiments; the pure Mg and pure Zn ingots are cut into large pieces, and the pure Mg, Zn ingots, Si particles and Mg-Gd master alloy are placed in a vacuum inductio...

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Abstract

The invention discloses a preparation method of a controllably degradable component gradient magnesium-based implant material, and the method comprises the following steps of: (1) taking pure magnesium, pure zinc, silicon particles and Mg-Gd alloy as raw materials, removing oxidation films on the surfaces of the raw materials, and performing drying for later use; (2) smelting the raw materials to obtain an Mg-Zn-Si-Gd magnesium-based implant material; (3) carrying out homogenization heat treatment on the Mg-Zn-Si-Gd, and cooling the Mg-Zn-Si-Gd; (4) cutting the Mg-Zn-Si-Gd wire to obtain an Mg-Zn-Si-Gd plate, and cleaning and polishing the Mg-Zn-Si-Gd plate; (5) disposing a blind hole in the Mg-Zn-Si-Gd plate, filling the blind hole with HAP, and conducting compaction; (6) carrying out stirring friction processing on the Mg-Zn-Si-Gd plate filled with HAP to prepare a component gradient magnesium-based implant material; (7) carrying out heat treatment on the component gradient magnesium-based implant material; and (8) rolling the component gradient magnesium-based implant material. The preparation method is simple, fine-particle HAP with a bone repair function is adopted, the magnesium-based implant material with high biological activity and hydroxyapatite gradient distribution is obtained, the biocompatibility and the safety are good, and rapid formation of new tissues can be promoted after the magnesium-based implant material is implanted into a human body.

Description

technical field [0001] The invention relates to the technical field of metal materials, in particular to a preparation method of a biomedical magnesium-based material, in particular to a preparation method of a controlled-degradable composition-gradient magnesium-based implant material. Background technique [0002] With the aging of the social population and major breakthroughs in biotechnology, biomedical materials have gradually entered major hospitals and realized clinical medical treatment such as diagnosis, treatment, and repair of the human body; among them, biodegradable biomagnesium alloys are permanent implants. (such as bone tissue repair materials) an ideal substitute material. Compared with traditional metal hard tissue implant materials, medical magnesium alloy materials have many significant advantages: (1) Appropriate mechanical properties: the density of magnesium is similar to that of human bone; magnesium alloys have similar mechanical properties to natura...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C1/03C22C23/04C22F1/06C22F3/00A61L27/04
CPCC22C1/03C22C23/04C22F1/06C22F3/00A61L27/047
Inventor 丛孟启张扬张云龙刘骁卢雅琳李小平雷卫宁
Owner JIANGSU UNIV OF TECH
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