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Up-conversion luminescent nano crystalline material and application thereof in specific immuno-detection

A nanocrystalline material, immunodetection technology, applied in the direction of luminescent materials, nanotechnology for materials and surface science, nanotechnology, etc., can solve the limited application, the lack of effective monitoring methods for the immediate detection of chronic obstructive pulmonary disease, etc. problem, to achieve the effect of good biocompatibility

Inactive Publication Date: 2022-02-22
温州广立生物医药科技有限公司
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Problems solved by technology

However, point-of-care testing for COPD still lacks effective monitoring methods, which greatly limits their application in point-of-care testing

Method used

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  • Up-conversion luminescent nano crystalline material and application thereof in specific immuno-detection
  • Up-conversion luminescent nano crystalline material and application thereof in specific immuno-detection
  • Up-conversion luminescent nano crystalline material and application thereof in specific immuno-detection

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Experimental program
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Embodiment Construction

[0025] 1. Experimental part

[0026] 1.1 Main raw materials and reagents:

[0027] Bismuth acetate (99.0%), trichloroacetic acid (99.0%), trifluoroacetic acid (99.0%), calcium acetate (99.0%), erbium acetate (99.9%), alkylphenol ethoxylate (Igepal CO-520), Oleic acid (90.0%) and octadecene (90.0%) were purchased from Sigma-Aldrich Company, goat anti-mouse IgG, specific antibody protein 1, and specific antibody protein 2 were purchased from Grelin Biotechnology Co., Ltd., absolute ethanol , tetraethylorthosilicate (TEOS) and concentrated hydrochloric acid were purchased from Sinopharm Chemical Reagent Co., Ltd.

[0028] 1.2 CaClF: Bi / Er@SiO 2 Preparation of nanocrystals:

[0029] Taking CaClF:10Bi / 20Er nanocrystals as an example, 0.1 mmol bismuth acetate, 0.7 mmol calcium acetate, 0.2 mmol erbium acetate, 2 mL trifluoroacetic acid, 2 mL trichloroacetic acid, 10 mL oleic acid and 25 mL octadecyl Add ene into the three-necked flask, under the condition of nitrogen protection ...

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Abstract

The invention relates to the field of novel nano crystalline materials and instant detection thereof, in particular to an up-conversion luminescent nano crystalline material, a preparation method thereof and application thereof in specific immuno-detection of chronic obstructive pulmonary disease. The molecular formula of the up-conversion luminescent nano crystalline material is CaClF:Bi / Er@SiO2. The surface of the nano crystalline material is coated with SiO2 to obtain a large number of hydrophilic hydroxyl groups, the hydrophilic hydroxyl groups can be covalently coupled with antibody protein to form a fluorescence labeled antibody for specific binding and detection of a target antigen, and the nano crystalline material has good bio-compatibility.

Description

technical field [0001] The present application relates to a novel nanocrystalline material and its instant detection field, in particular to an up-conversion luminescent nanocrystalline material and its preparation method and its application in the specific immunological detection of chronic obstructive pulmonary disease. Background technique [0002] Rare earth fluoride is an excellent down-conversion and up-conversion matrix material. Rare-earth ion-doped fluorides hold great promise in biological applications and photonic devices, especially in bioluminescence labeling, surgical equipment, and medical analysis involving optical components. His low autofluorescence background, large anti-Stokes shift, sharp emission bandwidth, high resistance to photobleaching, high penetration depth and time resolution advantages make it an excellent substitute for organic fluorophores and quantum dots , but the morphology of rare earth fluoride crystals is affected by many factors. In a...

Claims

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Application Information

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IPC IPC(8): C09K11/02C09K11/61B82Y20/00B82Y30/00B82Y40/00G01N33/543
CPCC09K11/025C09K11/7705B82Y20/00B82Y30/00B82Y40/00G01N33/54346G01N2800/122
Inventor 王从相王清清王双兰
Owner 温州广立生物医药科技有限公司
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