Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Polylactic acid composite biological material as well as preparation method and application thereof

A composite biomaterial, polylactic acid technology, applied in the field of polylactic acid composite biomaterials and its preparation, can solve problems such as strong immune response, impact on bone repair or vascular effect, implantation failure, etc., and achieve adjustable pore size distribution, which is beneficial to Osteogenic differentiation of cells and the effect of easy operation

Pending Publication Date: 2022-02-15
INST OF MEDICINE & HEALTH GUANGDONG ACAD OF SCI
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the immune response after biomaterial implantation will also affect the effect of bone repair or angiogenesis, and the immune response is too strong, which will lead to implant failure

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Polylactic acid composite biological material as well as preparation method and application thereof
  • Polylactic acid composite biological material as well as preparation method and application thereof
  • Polylactic acid composite biological material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] This embodiment has prepared a kind of containing 2wt% APTES-M 2 S’s 3D printed PLA bracket, the specific process is:

[0059] S1: add 2g of M 2 S was ultrasonically dispersed in 100mL of methanol solution (30min), then, under stirring, 2mL of APTES was added dropwise, stirred at 65°C for 6 hours, washed twice with deionized water and washed twice with alcohol to obtain APTES-M 2 S;

[0060] S2: Dissolve 10g of PLA in 200mL of chloroform; then 0.2g of APTES-M 2 S, to get 2wt% APTES-M 2 APTES-M for S 2 S / PLA complex; ultrasonically disperse for 10 min, stir for 5 min, repeat twice; then add ethanol slowly under stirring to precipitate the complex;

[0061] S3: 3D printed bracket.

Embodiment 2

[0063] This embodiment has prepared a kind of containing 5wt% APTES-M 2 S’s 3D printed PLA bracket, the specific process is:

[0064] S1: add 2g of M 2 S was ultrasonically dispersed in 200mL of dichloromethane solution (30min), then, under stirring, 2mL of APTES was added dropwise, stirred at 65°C for 6 hours, washed twice with deionized water and washed twice with alcohol to obtain APTES-M 2 S;

[0065] S2: Dissolve 15g of PLA in 200mL of chloroform; then add 0.75g of APTES-M 2 S, to get 5wt% APTES-M 2 APTES-M for S 2 S / PLA complex; ultrasonically disperse for 10 min, stir for 5 min, repeat twice; then add ethanol slowly under stirring to precipitate the complex;

[0066] S3: 3D printed bracket.

Embodiment 3

[0068] This embodiment has prepared a kind of containing 10wt% APTES-M 2 S’s 3D printed PLA bracket, the specific process is:

[0069] S1: add 2g of M 2 S was ultrasonically dispersed in 400mL of dichloromethane solution (30min), then, under stirring, 2mL of APTES was added dropwise, stirred at 65°C for 6 hours, washed twice with deionized water and washed twice with alcohol to obtain APTES-M 2 S;

[0070] S2: Dissolve 5g of PLA in 100mL of dichloromethane; then add 0.5g of APTES-M 2 S, get 10wt% APTES-M 2 APTES-M for S 2 S / PLA complex; ultrasonically disperse for 10 min, stir for 5 min, repeat twice; then add ethanol slowly under stirring to precipitate the complex;

[0071] S3: 3D printed bracket.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a polylactic acid composite biological material as well as a preparation method and application thereof. The polylactic acid composite biological material comprises a compound of which the surface is coated with a silane coupling agent magnesium silicate and polylactic acid. The polylactic acid composite biological material can obviously promote adhesion and proliferation of rat bone marrow mesenchymal stem cells and activity expression of alkaline phosphatase, and is beneficial to promoting in-vivo osteogenesis. The preparation method is simple and convenient to operate; wherein the prepared polylactic acid composite biological material and the 3D biological printing scaffold have excellent in-vitro degradability and biological activity, can release silicon and magnesium ions, are beneficial to cell osteogenic differentiation and can be applied to tissue engineering.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to a polylactic acid composite biological material and its preparation method and application. Background technique [0002] Bone regeneration in large defect areas is a major clinical challenge because the gap between fracture ends exceeds a critical distance, resulting in a poor osteoconductive and osteoinductive microenvironment. Autologous bone grafting is currently the gold standard for the treatment of bone defects. However, this treatment has certain limitations due to the size of the graft and complications at the donor site (eg, infection, persistent pain, etc.). Therefore, it is of great significance to search for artificial bone repair biomaterials for bone regeneration. [0003] Polylactic acid (PLA) is an excellent scaffold material, and PLA has been widely used in various modalities or biomedical applications in bone tissue engineering. These PLA scaf...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08L67/04C08K3/34C08K9/06A61L27/02A61L27/18A61L27/50A61L27/54A61L27/56B33Y70/10B33Y80/00
CPCC08K9/06C08K3/34A61L27/025A61L27/18A61L27/56A61L27/54A61L27/50B33Y70/10B33Y80/00A61L2430/02A61L2300/102A61L2300/412C08L2201/06C08L2203/02C08L67/04
Inventor 吴婷婷王兆振施奕万周新婷林承雄许为康赵瑞芳
Owner INST OF MEDICINE & HEALTH GUANGDONG ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com